Retinal capillary hemangioma / Hemangioma capilar retiniano

This manuscript describes a case of a retinal capillary hemangioma which had been impairing our patient's vision for a number of years. We performed widefield retinal imaging which revealed the patient's vasoproliferative tumor, as well as fluorescein angiography, which displayed its intricate vascular network, depicting the characteristic vascular nature of this vasoproliferative tumor. This case also underlines the importance of ruling out other disease locations due to its association with von Hippel-Lindau syndrome

Este manuscrito describe un caso de hemangioma capilar retiniano que afectaba la visión de nuestra paciente durante varios años. Realizamos imágenes de retina de campo amplio que revelaron el tumor vasoproliferativo de la paciente, así como una angiografía fluoresceínica que mostró su intrincada red vascular, destapando la naturaleza vascular característica de este tumor vasoproliferativo. Este caso también acentúa la importancia de descartar otras localizaciones de la enfermedad por su asociación con el síndrome de von Hippel-Lindau

Association between inflammatory bowel disease and uveal melanoma: case report of two young adults and a literature review.

INTRODUCTION: Uveal melanoma is a rare tumour caused by genetic factors and alterations in the immune response. Inflammatory bowel disease (IBD) is a multifactorial chronic inflammatory disorder characterized by an inappropriate or excessive immune response. The two main types of IBD are Crohn's disease (CD) and ulcerative colitis (UC). A diagnosis of IBD and the use of immunosuppressive drugs are both independently associated with an increased risk of developing skin melanoma. The association between IBD and uveal melanoma (UM) has not been previously described. CASES DESCRIPTION: Two young Caucasian men, aged 24 and 28, developed UM 3 and 15 years, respectively, after being diagnosed with IBD. Both received long-term treatment with immunomodulatory drugs, with periodic switching among the drugs due to the refractory nature of IBD. In both cases, melanoma was treated by brachytherapy with iodine-125 COMS plaque implant at a dose of 75 Gy. DISCUSSION: Chronic inflammation can promote cell proliferation and growth. The use of immunomodulatory drugs is associated with an increased risk of developing melanoma and non-melanoma skin cancer. The two patients described in this report both had long-standing IBD treated with immunomodulatory drugs. It seems reasonable to suggest that these two factors may have promoted the development of uveal melanoma. More studies are warranted to investigate and confirm this possible association.