ABSTRACT
The aim of this study was to investigate the efficacy, tolerability, and safety of isradipine in hypertensive diabetic patients. Twenty-eight patients (14 men and 14 women), of whom 15 had type II (non-insulin-dependent) and 13 had type I (insulin-dependent) diabetes mellitus, received isradipine for 6 months. A significant reduction was observed in both systolic and diastolic blood pressures (P < .00005). There were no significant differences between the type I and type II diabetes patients; metabolic control remained stable. Moderate or slight headaches were reported by four patients. In conclusion, the overall efficacy of isradipine and its tolerability were found to be very good.
Subject(s)
Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 2/complications , Hypertension/drug therapy , Isradipine/therapeutic use , Adult , Diabetes Mellitus, Type 1/blood , Diabetes Mellitus, Type 2/blood , Female , Glycated Hemoglobin/analysis , Glycated Hemoglobin/drug effects , Humans , Hypertension/blood , Hypertension/complications , Isradipine/adverse effects , Male , Middle Aged , Treatment OutcomeABSTRACT
The authors review all the cases of Carcinoma of Unknown Primary Site admitted to a medical service during a 3-year period (1987-1989). These cases represented 9% of all the neoplastic diseases admitted during the aforementioned period. Most of the patients presented extensive metastatic disease. The main histologic type was adenocarcinoma. The most useful of all the ancillary exams requested for primary localization and staging purposes was the computerized axial tomography (CT). The primary localization was achieved in two cases (one while the patient was still alive, and one on autopsy). The low performance status of the patients, together with the existence of advanced metastatic disease, precluded more than palliative therapy in most of the cases. The mortality of this series was 40% (4/10), with 3 autopsies performed. The authors compare their experience with the literature available, focusing the need for a work-up based on strict diagnostic criteria based on the histology and supported by specific laboratory tests. They also underline the value of the CT scan as the most useful exam in these circumstances.
Subject(s)
Neoplasms, Unknown Primary , Adult , Aged , Aged, 80 and over , Female , Hospitals , Humans , Incidence , Internal Medicine , Male , Middle Aged , Neoplasms, Unknown Primary/diagnosis , Neoplasms, Unknown Primary/epidemiology , Neoplasms, Unknown Primary/pathology , Neoplasms, Unknown Primary/therapy , Portugal , Retrospective StudiesABSTRACT
Pharmacological aspects of presently used insulins are reviewed. A discussion of different forms of insulin therapy in insulin dependent and non insulin dependent diabetes mellitus is presented.
Subject(s)
Diabetes Mellitus, Type 1/drug therapy , Diabetes Mellitus, Type 2/drug therapy , Insulin Resistance , Insulin/therapeutic use , Humans , Insulin/pharmacokinetics , Insulin/pharmacologyABSTRACT
Os autores discutem os aspectos clinicos e patologicos da pneumatose cistoide intestinal num homem de 61 anos de idade, enfatizando as caracteristicas clinicas, radiologicas e histologicas que a distinguem de outras doencas intestinais
