ABSTRACT
Experimental histoplasmic choroiditis was produced in primates by intracarotid injections of living H. capsulatum organisms. The severity of the choroiditis varied with inoculum size, as well as with site of injection (common carotid vs. internal carotid artery). A reproducible model of histoplasmic choroiditis in primates was produced with an internal carotid injection of 5,000 to 10,000 organisms/lb. The clinical and histopathological course of this acute choroiditis over the first 30 days is presented.
Subject(s)
Choroiditis/pathology , Disease Models, Animal , Histoplasmosis/pathology , Acute Disease , Animals , Carotid Arteries , Carotid Artery, Internal , Fluorescein Angiography , Haplorhini , Injections, Intra-Arterial , Macaca , Macaca mulattaABSTRACT
Specular microscopy in a case of pathologically proved epithelial downgrowth demonstrated a characteristic pattern of cell borders in the area of the epithelial downgrowth. This noninvasive clinical test may prove to be helpful in the early diagnosis of epithelial ingrowth following various intraocular surgical procedures.
Subject(s)
Epithelium/pathology , Ophthalmologic Surgical Procedures , Postoperative Complications/pathology , Anterior Chamber/pathology , Cataract Extraction , Cornea/pathology , Corneal Diseases/pathology , Eye/pathology , Female , Fistula/pathology , Humans , Iris/pathology , Microscopy , Middle Aged , Ophthalmoscopy , Postoperative Complications/diagnosisABSTRACT
Experimental E. coli endophthalmitis was produced in rabbits. The Limulus lysate test was applied to aqueous and vitreous samples at various intervals after the intravitreal injection of E. coli organisms. Results indicated that this test is feasible using vitreous and aqueous samples. The Limulus test was positive for E. coli endotoxin within hours after infection, requiring only 1 hr to determine the presence of endotoxin after sampling. This test may have some value in the rapid diagnosis of gram-negative endophthalmitis.
