Tumor-Intrinsic Enhancer of Zeste Homolog 2 Controls Immune Cell Infiltration, Tumor Growth, and Lung Metastasis in a Triple-Negative Breast Cancer Model.

Triple-negative breast cancer (TNBC) is an aggressive and highly metastatic type of tumor. TNBC is often enriched in tumor-infiltrating neutrophils (TINs), which support cancer growth in part by counteracting tumor-infiltrating lymphocytes (TILs). Prior studies identified the enhancer of zeste homolog 2 (EZH2) as a pro-tumor methyltransferase in primary and metastatic TNBCs. We hypothesized that EZH2 inhibition in TNBC cells per se would exert antitumor activity by altering the tumor immune microenvironment. To test this hypothesis, we used CRISPR to generate EZH2 gene knockout (KO) and overexpressing (OE) lines from parent (wild-type-WT) 4T1 cells, an established murine TNBC model, resulting in EZH2 protein KO and OE, respectively. In vitro, EZH2 KO and OE cells showed early, transient changes in replicative capacity and invasiveness, and marked changes in surface marker profile and cytokine/chemokine secretion compared to WT cells. In vivo, EZH2 KO cells showed significantly reduced primary tumor growth and a 10-fold decrease in lung metastasis compared to WT cells, while EZH2 OE cells were unchanged. Compared to WT tumors, TIN:TIL ratios were greatly reduced in EZH2 KO tumors but unchanged in EZH2 OE tumors. Thus, EZH2 is key to 4T1 aggressiveness as its tumor-intrinsic knockout alters their in vitro secretome and in vivo primary tumor growth, TIN/TIL poise, and metastasis.

Sleep quality and executive function in a diverse sample of healthy young adults.

Few studies examine the relationship between sleep and executive function in diverse samples of young adults. Our research aims to fill this gap by analyzing how self-reported sleep quality is related to informant-rated executive function as a whole and its working memory component in a diverse sample of 29 healthy college students. Using the self-report measure, the Pittsburgh Sleep Quality Index (PSQI), we divided our sample into two groups based on cutoff criteria (score ≥5: poor sleep): good sleep quality (n = 11) and poor sleep quality (n = 18). Participants were on average 20.86 years old. Informants rated participants' executive functioning and working memory using the Frontal Systems Behavior Scale (FrSBe) and Behavior Rating Inventory of Executive Function (BRIEF). Individuals in the poor sleep quality group were reported as having significantly worse executive function and working memory scores. Young adult college students who report less than 7 hours of sleep per night have lower scores on informant measures of working memory and executive function. This study raises awareness about how self-reported sleep experiences are related to other's observation of cognitive abilities in everyday life in a diverse young adult sample.

New Insights into the Exploitation of Vitis vinifera L. cv. Aglianico Leaf Extracts for Nutraceutical Purposes.

The leaves of Vitis vinifera L. have been used for a long time in traditional medicine for the treatment of many ailments. Grape polyphenols, indeed, have been demonstrated to be able to defend against oxidative stress, responsible for various disorders such as cancer, diabetes and neurodegenerative diseases. The effects of different extraction techniques, Soxhlet (SOX), Accelerated Solvent (ASE 40, ASE 50) and Ultrasound Assisted Extraction (UAE) were studied in this work to evaluate their impact on the chemical profile and bioactive potential of Vitis vinifera L. (cv. Aglianico) leaf extracts. The phytochemical profile was investigated by HPLC-DAD and 9 phenolic compounds were identified and quantified in the extract. Moreover, the antioxidant, anticholinesterase and antityrosinase activities were evaluated. In detail, the total polyphenol content and antioxidant activity (2,2-diphenyl-1-picrylhydrazyl, Oxygen Radical Absorbance Capacities and ß-Carotene Bleaching assays) were evaluated and compared to assess the Relative Antioxidant Capacity Index (RACI). To test the inhibitory activity of extracts towards cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition assays were performed. SOX and ASE 50 have shown the highest value of RACI, 0.76 and 0.65, respectively. Regarding enzymatic inhibitory activity, ASE 50 (IC50 = 107.16 ± 8.12 µg/mL) and SOX (IC50 = 171.34 ± 12.12 µg/mL) extracts exhibited the highest AChE and BChE inhibitory activity, respectively, while UAE (IC50 = 293.2 ± 25.6 µg/mL, followed by SOX (IC50 = 302.5 ± 38.3 µg/mL) showed the highest tyrosinase inhibition value. Our results demonstrated for the first time that Aglianico leaves are important sources of phenols that could be used to prevent oxidative stress and be potentially helpful in diseases treatable with tyrosinase and cholinesterase inhibitors, like myasthenia gravis or Alzheimer's.

[Myelophthisis and gastric cancer. An unusual association]. / Mieloptisis y cáncer gástrico. Una asociación infrecuente.

The infiltration of the bone marrow y non-hematopoietic cells is called myelophthisis. In patients with gastric cancer, this invasion is extremely infrequent and the survival is usually less than three months. We present the case of a 35-year-old man with bone marrow involvement secondary to diffuse gastric carcinoma of signet ring cells.

Se denomina mieloptisis a la infiltración de la médula ósea por células no hematopoyéticas. En pacientes con cáncer gástrico esta invasión es extremadamente infrecuente y la supervivencia suele ser menor a tres meses. Presentamos el caso de un hombre de 35 años con compromiso de la médula ósea secundario a un carcinoma gástrico difuso de células en anillo de sello.

Mieloptisis y cáncer gástrico: Una asociación infrecuente / Myelophthisis and gastric cancer. An unusual association

Se denomina mieloptisis a la infiltración de la médula ósea por células no hematopoyéticas. En pacientes con cáncer gástrico esta invasión es extremadamente infrecuente y la supervivencia suele ser menor a tres meses. Presentamos el caso de un hombre de 35 años con compromiso de la médula ósea secundario a un carcinoma gástrico difuso de células en anillo de sello.

The infiltration of the bone marrow y non-hematopoietic cells is called myelophthisis. In patients with gastric cancer, this invasion is extremely infrequent and the survival is usually less than three months. We present the case of a 35-year-old man with bone marrow involvement secondary to diffuse gastric carcinoma of signet ring cells.

Deciphering the melatonin metabolism in Saccharomyces cerevisiae by the bioconversion of related metabolites.

Melatonin (Mel), originally considered a neurohormone, has been detected in beverages and food-fermented products in which yeast metabolism is highly important. This indolamine is synthesized from serotonin, with L-tryptophan being the initial substrate of both. Regarding Mel metabolism, the biosynthetic pathway in mammals consists in four-step reactions. However, six genes are implicated in the synthesis of Mel in plants, which suggest the presence of many pathways. The aim of this study was to provide new empirical data on the production of Mel and other indole-related compounds in the yeast Saccharomyces cerevisiae (S. cerevisiae). To this end, we performed the addition of the pathway intermediates in S. cerevisiae cells in different growth stages (exponential and arrested cells) to follow the bioconversion and new indolic compound production from them. The different bioconverted indolic compounds tested (L-tryptophan, 5-hydroxytryptophan, tryptamine, serotonin, N-acetylserotonin, 5-methoxytryptamine, and Mel) were analyzed by UHPLC-MS/MS from the extra- and intracellular contents. Our results showed that serotonin, in yeast, was prevalently formed via tryptophan decarboxylation, followed by tryptamine hydroxylation as in plants. Mel production from serotonin can be achieved by either N-acetylation, followed by O-methylation or O-methylation, in turn followed by N-acetylation. Accordingly, the classic pathway of Mel synthesis in vertebrates does not seems prevalent in yeast.

El consentimiento informado de los menores de edad en cirugía estética: situación actual legislativa / Informed consent of minors in cosmetic surgery: current legislative situation

Tras el escándalo de las prótesis mamarias Poly Implant Prothese(R), se realizó por orden judicial, la valoración médico-legal de las lesiones producidas por el implante de dichas prótesis mamarias, en el Instituto de Medicina Legal y Ciencias Forenses de Valencia, en 265 lesionadas; el 0,75% se implantaron con finalidad estética a menores de edad, una de ellas con tan solo 14,8 años de edad. A la vista de estos datos, surgió la necesidad de realizar una revisión de la situación actual legislativa del consentimiento informado del menor de edad en cirugía estética. Tras dicha revisión, se ha comprobado que en España no existe una normativa específica nacional sobre las intervenciones quirúrgicas con finalidad estética en menores de edad, a pesar de un precedente legislativo específico autonómico de la Comunidad de Andalucía del año 2009

Following the scandal of the Poly Implant Prothese(R) breast implants, the legal-medical assessment of the injuries caused by the implantation of these breast prostheses was carried out by court order by the Institute of Forensic Medicine and Forensic Sciences of Valencia, in 265 injured women; 0.75% were implanted for cosmetic purposes to minors, one of whom was only 14.8 years of age. In light of these data, the need arose for a review of the current legislative status of informed consent for minors in cosmetic surgery. Following this review, it has been verified that there is no specific national legislation in Spain governing surgical procedures for cosmetic purposes in minors, despite a specific regional legislative precedent from the Community of Andalusia in 2009

Recent trends in the determination of biogenic amines in fermented beverages - A review.

Biogenic amines (BA) are generally considered as a food hazard, even though there is not a threshold for these biomolecules in the European legislation, except for histamine in fishery products. These compounds are formed during the storage and processing of certain foods through microbiological activity, and when present in high concentrations, could have toxicological effects, causing health problems in consumers, especially to sensitive persons. This fact, in addition to the economical concern involved, makes it necessary to control the amounts of biogenic amines in foods. For all these reasons, literature on biogenic amines in different food products, especially in fermented beverages, is extensive. This review provides an overview of the most recent trends in the determination of biogenic amines in fermented beverages focusing on novelty, improvement and optimization of analytical methods. Hence, the different sample treatment procedures (including derivatization), the most important analytical techniques and the most frequent applications are described and discussed. Although biogenic amines have been determined in wine and other fermented beverages for decades, new advancements and technical possibilities have allowed to increase the accuracy and sensitivity of analytical methods, in order to overcome the challenges posed by the complex matrices and their high intrinsic variability. Thus, the different purposes of BA determination (food safety, production process or food microbiology research) and the most widely employed analytical techniques have been reviewed.

Preharvest methyl jasmonate and postharvest UVC treatments: increasing stilbenes in wine.

UNLABELLED: Stilbene-enriched wine is considered to be an interesting new food product with added value due to its potential health-promoting properties. Stilbene concentration in grape is highly variable and rather scarce. However, it can be increased by stress treatments. For this reason, numerous pre- and postharvest grape treatments, and some combinations of them, have been tested to maximize stilbene content in grapes. In the present manuscript, Syrah grapes were treated with (i) methyl jasmonate (MEJA), (ii) ultraviolet light (UVC), and (iii) methyl jasmonate and ultraviolet light (MEJA-UVC) and compared with untreated grapes. Afterward, winemaking was developed. Wine achieved by combination of both treatments (MEJA-UVC) contained significantly higher stilbene concentration (trans-resveratrol and piceatannol) than its respective control (2.5-fold). Wine quality was improved in color-related parameters (color intensity, L*, a*, b*, ΔE*, anthocyanins, and tannin). Moreover, MEJA-UVC wines obtained the highest score in sensorial analysis. To the best of our knowledge, this is the first time that pre- and postharvest treatments are combined to increase stilbenes in wine. PRACTICAL APPLICATION: The effect of treatment combination (methyl jasmonate and UVC light) on grape and wine was evaluated. Our results highlight the positive effect of the treatments in stilbene content, color parameters, and sensorial analysis. Moreover, added-value by-products were achieved.

Acetic acid bacteria and the production and quality of wine vinegar.

The production of vinegar depends on an oxidation process that is mainly performed by acetic acid bacteria. Despite the different methods of vinegar production (more or less designated as either "fast" or "traditional"), the use of pure starter cultures remains far from being a reality. Uncontrolled mixed cultures are normally used, but this review proposes the use of controlled mixed cultures. The acetic acid bacteria species determine the quality of vinegar, although the final quality is a combined result of technological process, wood contact, and aging. This discussion centers on wine vinegar and evaluates the effects of these different processes on its chemical and sensory properties.

Isorhapontigenin: a novel bioactive stilbene from wine grapes.

Stilbenes are a family of bioactive compounds found in plants. However, only a few stilbenes are present in the human diet. Grape and wine are the main dietary source of stilbenes, resveratrol and piceid being the most common ones. Ultraviolet C light (UVC) postharvest treatment was used to obtain significantly increased stilbene concentration in grapes. A new, previously undescribed-in-grapes stilbene was found after UVC treatment. The process followed to isolate and identify this unknown stilbene is described in the present work. This isolation involved several fractionation steps including counter current chromatography and semi-preparative HPLC due to its low concentration and the presence of structurally related compounds. The structure of the compound was unequivocally identified by NMR spectroscopy analyses including (1)H-NMR; COSY; ROESY; HSQC and HMBC. The compound was identified as isorhapontigenin (ISOR), a stilbene found in traditional Asian medicinal plants. To the best of our knowledge this is the first report of its occurrence in grapes.

Production of melatonin by Saccharomyces strains under growth and fermentation conditions.

Melatonin is a bioactive compound that is present in wine because it is contained in vinification grapes and synthesized by yeast during alcoholic fermentation. The purpose of this study was to determine the capacity of various Saccharomyces strains to form melatonin during its growth and alcoholic fermentation. A selection of yeasts including six S. cerevisiae (Lalvin CLOS, Lalvin ICV-D254, Enoferm QA23 Viniferm ARM, Viniferm RVA, and Viniferm TTA), one S. uvarum (Lalvin S6U) and one S. cerevisiae var. bayanus (Uvaferm BC) were tested to determine whether they produce melatonin in yeast extract peptose dextrose and synthetic must media in a variety of conditions. Two S. cerevisiae strains (ARM, and QA23), the S. uvarum and the S. cerevisiae var. bayanus, synthesized melatonin. The conditions in which they did so, however, were different: the QA23 strain produced melatonin best in a medium with a low concentration of reducing sugars and Lalvin S6U and Uvaferm BC required a synthetic must under fermentation conditions. Melatonin synthesis largely depended on the growth phase of the yeasts and the concentration of tryptophan, reducing sugars and the growth medium. These results indicate that melatonin may have a role as a yeast growth signal molecule.

Wine, resveratrol and health: a review.

Several studies have cited the Mediterranean diet as an example of healthy eating. In fact, the Mediterranean diet has become the reference diet for the prevention of cardiovascular disease. Red wine seems to be an essential component of the diet, since moderate consumption of wine is associated with lower risk and mortality from cardiovascular disease. Evidence is also accumulating that wine helps prevent the development of certain cancers. Of all the many components of wine, resveratrol, which is a natural component specifically present in wine, has been identified as being mainly responsible for these health-promoting properties. Many valuable properties such as cardioprotective and anticarcinogenic activity have been attributed to resveratrol; however, its bioavailability is quite low. The bioactivity of metabolites derived from resveratrol, and the accumulation of resveratrol in vital organs are still under study, but there are high expectations of positive results. Other stilbene compounds are also considered in this review, despite being present in undetectable or very small quantities in wine. The present paper reviews all aspects of the health properties of wine, bioactive compounds found in wine, and their concentrations, bioavailability and possible synergistic effects.

Mejora de la efectividad en el manejo del riesgo cardiovascular de pacientes diabéticos tipo 2 en atención primaria / Improved effectiveness in the management of cardiovascular risk among type 2 diabetic patients in primary health care

Objetivos: Determinar el impacto de la implementación de una guía en la valoración del riesgo cardiovascular de pacientes en alto riesgo (diabéticos tipo 2), y en la adecuación del tratamiento antihipertensivo y antiagregante.Diseño: Estudio semiexperimental, no aleatorizado, prospectivo, con grupo control concurrente.EmplazamientoDos centros de salud de Málaga.Participantes: Médicos de familia.Intervenciones: Implementación de la guía mediante intervenciones multicomponentes sobre los médicos de familia del centro experimental.Mediciones principales: Variable principal de resultado: grado de estimación del riesgo cardiovascular en población con elevado riesgo (diabéticos). Variables secundarias: adecuación del tratamiento antihipertensivo y antiagregante.Resultados: Se detectaron importantes diferencias en la estimación del riesgo cardiovascular a favor del grupo experimental (el 74,36 frente al 7,63%; riesgo relativo [RR]=9,74; intervalo de confianza [IC] del 95%, 5,15–18,43; p=0,0001). Las pautas de antiagregación se ajustaron más a las recomendaciones de la evidencia en el grupo intervención (el 51,28 frente al 36,44%; RR=1,407; IC del 95%, 1,04–1,89; p=0,026), al igual que en antihipertensivos, aunque sin significación (el 80 frente al 66,27%; RR=1,207; IC del 95%, 0,99–1,46.Conclusiones: Una estrategia de implementación multicomponente de una guía para el manejo de pacientes con elevado riesgo cardiovascular mejora la adherencia a intervenciones efectivas por parte de médicos de familia(AU)

Objectives: To determine the impact of the implementation of a guidelines in theassessment of cardiovascular risk in high-risk patients (type2diabetes) in health centres, and to analyse the appropriateness of antihypertensive and antiplatelet treatment in diabetic patients.Design: Quasi-experimental, non-randomised, prospective study with concurrent control group.Placement: Two health centres in Málaga.Participants: General practitioners of the two centres.Interventions: The guideline was implemented through a multifaceted intervention in family physicians in the experimental centre.Main outcomes: Rate of cardiovascular risk assessment in high risk population. Secondary: appropriateness of antihypertensive and antiplatelet treatment.Results: Large differences were detected in the cardiovascular risk assessment, improving in the experimental group (74.36% vs. 7.63%; RR ¼ 9.74; 95%CI, 5.15–18.43; P ¼.0001). Similarly, the antiplatelet use was more in line with the guidelines recommendations in theintervention group (51.28% vs. 36.44%; RR ¼ 1.407; 95%CI, 1.04–1.89; P ¼.026), andin antihypertensive drugs, although with no statistical significance (80% vs. 66.27%;RR ¼ 1.207; 95%CI, 0.99–1.46).Conclusions: A multifaceted intervention for the implementation of a guideline for the management of high risk cardiovascular patients, improves the adherence to effectiveinterventions by family physicians(AU)

[Improved effectiveness in the management of cardiovascular risk among type 2 diabetic patients in primary health care]. / Mejora de la efectividad en el manejo del riesgo cardiovascular de pacientes diabéticos tipo 2 en atención primaria.

OBJECTIVES: To determine the impact of the implementation of a guidelines in the assessment of cardiovascular risk in high-risk patients (type 2 diabetes) in health centres, and to analyse the appropriateness of antihypertensive and antiplatelet treatment in diabetic patients. DESIGN: Quasi-experimental, non-randomised, prospective study with concurrent control group. PLACEMENT: Two health centres in Málaga. PARTICIPANTS: General practitioners of the two centres. INTERVENTIONS: The guideline was implemented through a multifaceted intervention in family physicians in the experimental centre. MAIN OUTCOMES: Rate of cardiovascular risk assessment in high risk population. Secondary: appropriateness of antihypertensive and antiplatelet treatment. RESULTS: Large differences were detected in the cardiovascular risk assessment, improving in the experimental group (74.36% vs. 7.63%; RR = 9.74; 95% CI, 5.15-18.43; P = .0001). Similarly, the antiplatelet use was more in line with the guidelines recommendations in the intervention group (51.28% vs. 36.44%; RR = 1.407; 95% CI, 1.04-1.89; P = .026), and in antihypertensive drugs, although with no statistical significance (80% vs. 66.27%; RR = 1.207; 95% CI, 0.99-1.46). CONCLUSIONS: A multifaceted intervention for the implementation of a guideline for the management of high risk cardiovascular patients, improves the adherence to effective interventions by family physicians.

Simulated digestion and antioxidant activity of red wine fractions separated by high speed countercurrent chromatography.

Wine is an important source of dietary antioxidants because of its phenolic compound content. The antioxidant activity (AA) of pure monomer substances present in wines, such as phenolic acids, flavanols, and anthocyanins, has already been described, but the AA of polymeric phenols is still unknown. In this study, we have fractionated a red wine by countercurrent chromatography (CCC) into four fractions: fraction 1, made up of polymeric compounds; fraction 2, containing malvidin-3-glucoside; fraction 3, containing peonidin-3-glucoside; and fraction 4, containing vitisin A. The AA of these fractions was determined by oxygen radical absorbance capacity and ferric reducing ability assays. The weight of fraction 1 was the largest, so this was the largest contributor to the AA of the wine. However, the antioxidant powers (muM Trolox/g fraction) of fractions 2-4 were similar and higher than that of fraction 1. We also determined AA before and after in vitro gastric and intestinal digestions. After gastric digestion, the AA was 100-1000 times higher than the original fraction values. Gallic acid was determined in gastric and intestinal digested fractions. After intestinal digestion, the concentrations of simple phenols, such as caffeic acid, p-coumaric acid, and protocatechualdehyde, increased as they were released from the fractions under our conditions. Protocatechuic acid was determined in more intestinal digested fractions than in gastric digested fractions. These results partly explain the increase in AA after the digestion and indicate the relevance of polymeric polyphenolic compounds as precursors of smaller molecules with biological activity.

El fruto de la acerola: composición, características productivas e importancia económica / The acerola fruit: composition and possible alimentary uses

El objetivo de esta revisión es caracterizar el fruto de la acerola, detallando así sus aspectos taxonómicos, vegetativos, de composición y de mercado. También se evalúa su posible utilización como ingrediente alimentario en vistas a la producción de alimentos funcionales. Para la realización de esta revisión bibliográfica se han consultado bases de datos internacionales (Scifinder Scholar y Medline) y artículos originales que han sido localizados y proveídos principalmente por los Recursos Electrónicos de la Biblioteca de la Universidad de Sevilla y la Universidad do Vale do Itajaí (Santa Catarina, Brazil).La acerola (Malpighia emarginata Sessé y Mociño ex DC) es una especie arbustiva que se desarrolla en zonas de climas tropical y subtropical. Su origen se centra en el sur de México, América Central y zona septentrional de Sudamérica. Su denominación se adoptó en 1986 por el Consejo Internacional de Recursos Genéticos Vegetales. Malpighia emarginata presenta un fruto subglobuloso en forma de drupa, el cual posee tres semillas que representan entre el 19 y el 25 por ciento del peso total. El diámetro del fruto varía de 1 a 4 cm y el peso de 2 a 15 g. Presenta una coloración verde cuando está en desarrollo, cambiando a tonos amarillos y rojos cuando está maduro. La maduración ocurre en corto espacio de tiempo. El período de fructificación es de 3 a 4 veces al año. Cada planta produce cerca de 20 a 30 kg de frutos anualmente. La fruta de acerola proporciona macro y micronutrientes: proteínas (0,21 g/100 g), grasas (0,23 g/100 g), carbohidratos (3,57 g/100 g), sales minerales (hierro (0,24 mg/100 g, calcio 11,7 mg/100 g, fósforo 17,1 mg/100g) y vitaminas (tiamina (0,02 mg/100 g, riboflavina 0,07 mg/100 g, piridoxina 8,7 mg/100 g). Hay que destacar su elevado contenido en vitamina C (695 a 4827 mg/100 g), el cual ha inducido un gran consumo de esta fruta en los últimos años, de ahí su importante valor económico. La acerola también presenta carotenoides y...

Revisión de los métodos de evaluación de la actividad antioxidante in vitro del vino y valoración de sus efectos in vivo / Review of the different methods for the evaluation of the in vitro antioxidant activity of wine and study of in vivo effects

El objetivo de esta revisión es el estudio de la actividad antioxidante del vino, analizando los distintos métodos que se han empleado en su evaluación. Esta actividad se relacionará, tanto desde el punto de vista cualitativo como cuantitativo, con el perfil de compuestos polifenólicos presentes en el vino. Los vinos tintos presentan actividades superiores a los blancos y la magnitud de dichos valores varía en función del método de análisis empleado. No existe un único compuesto polifenólico responsable mayoritariamente de la actividad antioxidante del vino, sino que ésta se explica por el conjunto de todos ellos. Para evaluar la influencia del consumo de vino tinto en el organismo humano se ha utilizado como biomarcador más frecuente la capacidad antioxidante del plasma, que incrementa su valor tras la ingesta del vino. Se expone que la evaluación de la actividad antioxidante in vitro del vino requiere el uso de diversos métodos que proporcionen una información diferente y complementaria. Los métodos in vivo tienen la ventaja de valorar las transformaciones metabólicas que sufren los fenoles en el organismo y que modifican su actividad. De los estudios realizados hasta la fecha se concluye que el vino interviene en la capacidad antioxidante del plasma de forma directa a través de sus compuestos polifenólicos e indirecta al aumentar la concentración plasmática de ácido úrico

Primer trasplante cubano de riñones pediátricos para un receptor adulto. Presentación de 1 caso / First Cuban transplantation of pediatric kidneys into an adult recipient. A case report

Se presentó el primer trasplante renal realizado en Cuba a un receptor adulto al cual se le injertaron ambos riñones de un donante de 2 años de edad fallecido por un trauma craneoencefálico; se expusieron los datos del trasplante así como la técnica de implante, inmunosupresión utilizada y la evolución clínica, humoral e imagenológica del postrasplante inmediato, que fue satisfactoria. Se tuvo en cuenta, además, un ingreso por enfermedad por citomegalovirus que complicó la evolución ulterior de la enferma, resuelto satisfactoriamente, así como el estado actual de la misma atendida en consulta externa. Se demostró que el doble trasplante renal de injertos procedentes de niños a un receptor adulto constituye en nuestro medio una opción valedera para el tratamiento de enfermos con insuficiencia renal terminal

Primer trasplante cubano de riñones pediátricos para un receptor adulto: presentación de 1 caso / First Cuban transplantation of pediatric kidneys into an adult recipient: a case report

Se presentó el primer trasplante renal realizado en Cuba a un receptor adulto al cual se le injertaron ambos riñones de un donante de 2 años de edad fallecido por un trauma craneoencefálico; se expusieron los datos del trasplante así como la técnica de implante, inmunosupresión utilizada y la evolución clínica, humoral e imagenológica del postrasplante inmediato, que fue satisfactoria. Se tuvo en cuenta, además, un ingreso por enfermedad por citomegalovirus que complicó la evolución ulterior de la enferma, resuelto satisfactoriamente, así como el estado actual de la misma atendida en consulta externa. Se demostró que el doble trasplante renal de injertos procedentes de niños a un receptor adulto constituye en nuestro medio una opción valedera para el tratamiento de enfermos con insuficiencia renal terminal(AU)