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1.
Neurogastroenterol Motil ; 18(9): 839-43, 2006 Sep.
Article in English | MEDLINE | ID: mdl-16918763

ABSTRACT

Postinfectious functional gastrointestinal disorders (FGIDs) may not be specific to gastroenteritis. This pilot study aimed to ascertain the 3- and 6-month incidence of functional gut disorders in people with non-gastrointestinal (GI) infection, gastroenteritis and healthy controls. This was a prospective study of three cohorts recruited from hospital (non-GI infections) and the community (others). FGIDs were diagnosed using self-completed Rome II modular questionnaires administered at baseline, 3 and 6 months. Thirty-six subjects with non-GI infection, 219 healthy subjects and 108 with bacterial gastroenteritis participated. No difference in incidence of FGID was detected between the GI and non-GI infection cohorts. Any FGID was more frequent in people who had a non-GI infection than in controls at both 3 [odds ratio: 4.34 (95% CI: 3.60-16.45)] and 6 months [4.76 (4.42-27.92)]. Irritable bowel syndrome (IBS) alone was more frequent in people with non-GI infections than in controls at 3 months (6.12 [1.30-29.12]) but did not quite reach statistical significance at 6 months (4.58 [0.79-26.46]). Our findings were unexpected. Postinfectious FGIDs may be related to non-GI and GI infection, although not all potential biases were controlled in study design. Further studies need to explore these preliminary findings and, if confirmed, the underlying mechanisms.


Subject(s)
Bacterial Infections/complications , Gastroenteritis/complications , Irritable Bowel Syndrome/epidemiology , Irritable Bowel Syndrome/etiology , Adolescent , Adult , Aged , Female , Humans , Incidence , Male , Middle Aged , Pilot Projects , Prospective Studies
2.
Eur Respir J ; 19(4): 756-64, 2002 Apr.
Article in English | MEDLINE | ID: mdl-11999006

ABSTRACT

Sulphasalazine prescribing is on the increase. Pulmonary toxicity and blood dyscrasias are rare side-effects. Numerous case reports have been published implicating sulphasalazine in pulmonary toxicity. The authors searched the literature for cases of sulphasalazine induced lung toxicity and the 50 cases identified are discussed here. All published case reports/letters referring to sulphasalazine and lung toxicity were studied. The search terms "sulphasalazine" and "sulfasalazine" were combined with the terms "lung", "pulmonary disease", "pneumonitis" and "pleuritis" using Medline and PubMed databases. Typical presentation of sulphasalazine-induced lung disease was with new onset dyspnoea and infiltrates on chest radiography. Common symptoms were cough and fever. Crepitations on auscultation and peripheral eosinophilia were noted in half of the cases. Sputum production, allergy history, rash, chest pain and weight loss were inconsistent findings. Pulmonary pathology was variable, the commonest being eosinophilic pneumonia with peripheral eosinophilia and interstitial inflammation with or without fibrosis. Fatal reports were infrequent. Most patients were managed by drug withdrawal with 40% prescribed corticosteroids. In conclusion, sulphasalazine lung disease should be distinguished from interstitial lung disease due to underlying primary disease. Despite the increase in sulphasalazine prescribing, pulmonary toxicity remains rare. The majority of patients with suspected sulphasalazine-induced lung disease improved within weeks of drug withdrawal and the need for corticosteroids is debatable.


Subject(s)
Antirheumatic Agents/adverse effects , Lung Diseases/chemically induced , Sulfasalazine/adverse effects , Antirheumatic Agents/therapeutic use , Colitis, Ulcerative/drug therapy , Female , Humans , Inflammatory Bowel Diseases/drug therapy , Male , Middle Aged , Sulfasalazine/therapeutic use
3.
ScientificWorldJournal ; 1 Suppl 2: 304-11, 2001 Nov 28.
Article in English | MEDLINE | ID: mdl-12805794

ABSTRACT

Atmospheric deposition of nitrogen (N) in California ecosystems is ecologically significant and highly variable, ranging from about 1 to 45 kg/ha/year. The lowest ambient concentrations and deposition values are found in the eastern and northern parts of the Sierra Nevada Mountains and the highest in parts of the San Bernardino and San Gabriel Mountains that are most exposed to the Los Angeles air pollution plume. In the Sierra Nevada Mountains, N is deposited mostly in precipitation, although dry deposition may also provide substantial amounts of N. On the western slopes of the Sierra Nevada, the majority of airborne N is in reduced forms as ammonia (NH3) and particulate ammonium (NH4+) from agricultural activities in the California Central Valley. In southern California, most of the N air pollution is in oxidized forms as nitrogen oxides (NOx), nitric acid (HNO3), and particulate nitrate (NO3-) resulting from fossil fuel combustion and subsequent complex photochemical reactions. In southern California, dry deposition of gases and particles provides most (up to 95%) of the atmospheric N to forests and other ecosystems. In the mixed-conifer forest zone, elevated deposition of N may initially benefit growth of vegetation, but chronic effects may be expressed as deterioration of forest health and sustainability. HNO3 vapor alone has a potential for toxic effects causing damage of foliar surfaces of pines and oaks. In addition, dry deposition of predominantly HNO3 has lead to changes in vegetation composition and contamination of ground- and stream water where terrestrial N loading is high. Long-term, complex interactions between N deposition and other environmental stresses such as elevated ozone (O3), drought, insect infestations, fire suppression, or intensive land management practices may affect water quality and sustainability of California forests and other ecosystems.


Subject(s)
Air Pollutants/analysis , Air Pollutants/toxicity , Atmosphere/chemistry , Ecosystem , Environmental Monitoring , Nitrogen/analysis , Nitrogen/toxicity , Trees/drug effects , Absorption , Agriculture , Air Pollutants/chemistry , California , Gases/analysis , Gases/chemistry , Gases/toxicity , Geography , Nitrates/analysis , Nitrates/chemistry , Nitrates/toxicity , Nitric Acid/analysis , Nitric Acid/chemistry , Nitric Acid/toxicity , Nitrogen/chemistry , Seasons , Trees/physiology
5.
Int J Clin Pract ; 52(5): 354-5, 1998.
Article in English | MEDLINE | ID: mdl-9796573

ABSTRACT

Pica is the persistent eating of a non-nutritional substance (as defined by the American Psychiatric Association) and is often associated with iron deficiency. Current literature leaves uncertain whether pica causes iron deficiency via its proposed effect on iron absorption or, conversely, whether iron deficiency causes pica. We report the case of a young girl from Nottingham who we believe developed pica secondary to her iron deficiency anaemia. To determine that her pica was not affecting gastrointestinal iron absorption we carried out iron absorption studies first under pica and then under normal dietary conditions.


Subject(s)
Anemia, Iron-Deficiency/complications , Pica/etiology , Adolescent , Anemia, Iron-Deficiency/blood , Female , Humans , Intestinal Absorption , Iron/pharmacokinetics , Pica/blood
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