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1.
Vascular ; 30(4): 650-660, 2022 Aug.
Article in English | MEDLINE | ID: mdl-34238080

ABSTRACT

PURPOSE: To elucidate the epidemiology, anatomical, presentation, classification, pathology, investigative modalities, management and prognosis of primary angiosarcoma of the aorta. MATERIAL AND METHODS: A systematic review of literature from the database inception to January 2021 in PubMed and Embase, CINAHL and Cochrane Library in accordance to PRISMA was conducted. Retrieval and extraction was performed by two independent reviewers. The hierarchy of the evidence was assessed through the National Institute for Health and Care Excellence Checklist. Data were subjected to pooled prevalence analysis, Kaplan-Meier survival and test of probability using log-rank analysis. This review is registered with International Prospective Register of Systematic Reviews: RD42021231314. RESULTS: 82 studies with n = 123 cases met the inclusion criterion. Abdominal (45%) aorta was the commonest anatomical site with female predominance in ascending aorta (4:1) and aortic arch (2:1). The longest survival was in the ascending aorta and the shortest in the abdominal aorta [540 (interquartile range [IQR], 7-1560 days vs. 180 (IQR, 1-5730 days)], respectively. The overall median survival was 210 days (IQR, 1-5730 days) or 7 months. Lack of metastasis (47%) was a marker of longer survival (p < 0.03) irrespective of other attributes. CONCLUSION: The pathophysiology appears to be a trend of increasing fatigue, fever and weight loss associated with segmental dysfunction of the aorta projecting occlusive or destructive phenotypes. Computed tomography angiography features of volume-occupying, bulky, polypoid (intraluminal), protrusive vegetation, hyper vascular without atherosclerotic lesions are extremely suggestive of PA of the aorta at 5th and 6th decades of life.


Subject(s)
Hemangiosarcoma , Aorta, Abdominal/diagnostic imaging , Aorta, Thoracic , Computed Tomography Angiography , Female , Hemangiosarcoma/complications , Hemangiosarcoma/diagnostic imaging , Hemangiosarcoma/therapy , Humans , Male , Tomography, X-Ray Computed
2.
Clin Appl Thromb Hemost ; 23(6): 601-606, 2017 Sep.
Article in English | MEDLINE | ID: mdl-26719355

ABSTRACT

BACKGROUND: Transfusion of blood products occurs frequently in ruptured abdominal aortic aneurysm surgery (rAAA). The aim of this study is to establish the impact of packed red blood cell (PRBC), fresh frozen plasma (FFP), and platelet (PLT) transfusion on the 30-day mortality and morbidity (thrombotic versus non thrombotic complications) of rAAAs. METHODS: A retrospective study of 90 consecutive rAAAs from November 2007 to June 2015 was conducted. Multivariable regression models were produced to determine blood products associated with 30-day morbidity and mortality post-rAAA. RESULTS: The overall mortality was 14.6%. At multivariable analyses, transfusion with FFP (>3 units) was independently associated with an increased risk of mortality (odds ratio [OR]: 11.27, 95% confidence interval [CI]: 1.13-96.72, P = .027). The overall morbidity was 26.8%, and subgroup analysis (thrombotic vs nonthrombotic complications) demonstrated transfusion of PLTs (>1 pool) to be independently associated with thrombotic events (OR: 4.3, 95% CI: 1.37-13.6, P = .012). Thrombotic events were responsible for 50% (n = 11 of 22) of all morbidities and mortalities (n = 6 of 12). CONCLUSION: Transfusion of FFP and PLTs may be associated with an increased risk of postoperative morbidity and mortality. The use of these blood components should be considered in the context of the patient's clinical and laboratory data as opposed to a fixed ratio to PRBCs. This may result in the reduction in thrombotic complications emerging in rAAA cohort.


Subject(s)
Aortic Aneurysm, Abdominal/therapy , Aortic Rupture/therapy , Blood Component Transfusion , Adolescent , Adult , Aged , Aged, 80 and over , Aortic Aneurysm, Abdominal/epidemiology , Aortic Aneurysm, Abdominal/mortality , Aortic Rupture/complications , Aortic Rupture/epidemiology , Aortic Rupture/mortality , Blood Component Transfusion/adverse effects , Erythrocyte Transfusion , Female , Humans , Male , Middle Aged , Morbidity , Mortality , Plasma , Platelet Transfusion/adverse effects , Thrombosis/etiology , Young Adult
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