ABSTRACT
SARS-CoV-2 enters host cells by binding angiotensin-converting enzyme 2 (ACE2). Through a genome-wide association study, we show that a rare variant (MAF = 0.3%, odds ratio 0.60, P=4.5×10-13) that down-regulates ACE2 expression reduces risk of COVID-19 disease, providing human genetics support for the hypothesis that ACE2 levels influence COVID-19 risk. Further, we show that common genetic variants define a risk score that predicts severe disease among COVID-19 cases.
ABSTRACT
OBJECTIVES: To determine the accuracy of using fellow-eye biometry for intraocular lens calculations for phacovitrectomy for macula off rhegmatogenous retinal detachments. METHODS: Retrospective case review of phacovitrectomies for consecutive macula off retinal detachments over 10 years. Optical and/or ultrasound biometry was performed for affected and fellow eyes. Prediction error was determined by calculating the difference between predicted and actual refractive outcomes. Results from fellow- and same-eye biometry were compared. RESULTS: Forty-two eyes were included. The mean prediction errors for fellow- and same-eye biometry were -0.01 ± 1.09 and -1.22 ± 2.32 dioptres, respectively, indicating a myopic shift for same eye biometry calculations. The mean absolute prediction errors for fellow and same eye biometry were 0.73 ± 0.80 and 1.57 ± 2.08 dioptres, respectively. The difference was statistically significant (P = 0.016). CONCLUSIONS: When appropriate, intraocular lens calculations using fellow-eye biometry for phacovitrectomy for macula off rhegmatogenous retinal detachments are accurate and better than those from same-eye biometry.
