ABSTRACT
Linezolid is an important agent for the treatment of infections because of vancomycin-resistant Enterococcus (VRE). This study identified independent predictors for isolation of linezolid-resistant VRE (LZD-R-VRE) and analyzed outcomes associated with linezolid resistance. Immunosuppression, prior surgery, and previous exposure to ß-lactam antibiotics were independent predictors for isolation of LZD-R-VRE but not for LZD-susceptible-VRE. Prior exposure to linezolid was not a predictor for isolation of LZD-R-VRE.
Subject(s)
Acetamides/therapeutic use , Drug Resistance, Bacterial , Enterococcus/drug effects , Gram-Positive Bacterial Infections/drug therapy , Gram-Positive Bacterial Infections/epidemiology , Oxazolidinones/therapeutic use , Vancomycin/pharmacology , Acetamides/pharmacology , Adult , Aged , Aged, 80 and over , Case-Control Studies , Enterococcus/isolation & purification , Female , Gram-Positive Bacterial Infections/microbiology , Humans , Linezolid , Male , Middle Aged , Oxazolidinones/pharmacology , Risk Factors , Treatment OutcomeABSTRACT
A retrospective case-case control study was conducted, including 60 cases with daptomycin-nonsusceptible vancomycin-resistant enterococci (DNS-VRE) matched to cases with daptomycin-susceptible VRE and to uninfected controls (1â¶1â¶3 ratio). Immunosuppression, presence of comorbid conditions, and prior exposure to antimicrobials were independent predictors of DNS-VRE, although prior daptomycin exposure occurred rarely. In summary, a case-case control study identified independent risk factors for the isolation of DNS-VRE: immunosuppression, multiple comorbid conditions, and prior exposures to cephalosporines and metronidazole.
