ABSTRACT
Viral infections are frequently present before the clinical manifestation of Guillain-Barre syndrome (GBS). Multiple studies on coronaviruses have shown that these viruses have neurotropic characteristics, and their molecular mimicry can induce inflammatory demyelinating neuropathy. Herein, we describe a case of a GBS in an 85-year-old patient infected with SARS-CoV-2, manifested with acute progressive symmetric ascending quadriparesis, urinary dysautonomia, and dysphagia, who responded well to treatment with intravenous human immunoglobulin.
Subject(s)
Acetamides/adverse effects , Anti-Bacterial Agents/adverse effects , Oxazolidinones/adverse effects , Thrombocytopenia/chemically induced , Thrombocytopenia/immunology , Acetamides/administration & dosage , Aged , Aged, 80 and over , Anti-Bacterial Agents/administration & dosage , Female , Humans , Injections, Intravenous , Linezolid , Male , Oxazolidinones/administration & dosage , Platelet CountABSTRACT
The study of true seronegative HIV-1 infections may have important implications for the diagnosis and prevention of HIV-1 infection. The case of an AIDS patient with persistently negative HIV serology is described. Genetic and phylogenetic analysis indicated that she was infected with A2 subsubtype HIV-1 transmitted by her seropositive and asymptomatic sexual partner. The clinical and serological discordant results suggest the presence of an immunological deficiency that prevents the formation of HIV-1-specific antibodies.
