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1.
Life (Basel) ; 12(12)2022 Dec 09.
Article in English | MEDLINE | ID: mdl-36556430

ABSTRACT

Due to its anticonvulsant properties, cannabidiol can be supportive as an adjuvant therapy in the management of drug resistant epilepsy. This retrospective observational study evaluates the intensity and frequency of the seizures of patients with drug-resistant epilepsy that have been treated with antiepileptic medication associated with CBD in low doses for at least 12 months. Thirty-four patients were included in the study. The most frequent diagnosis of epilepsy was focal symptomatic epilepsy and Lennox−Gastaut syndrome (35.2%). During the follow-up, there was a statistically significant decrease in the seizure frequency (t student p < 0.001). A high proportion of patients, 16, concluded the study with a total control of the seizures reaching a 100% improvement, 12 reported ≥ 75% improvement, 3 ≥ 50%, and 2 ≥ 25%; only 1 patient had an improvement of less than 25%. This is the first Latin American study that demonstrates that long-term CBD added to the usual drugs significantly reduces the frequency, duration, and type of seizures in the different etiologies of epilepsy, being especially effective on the seizures that are the most incapacitating, improving the quality of life of the individual and their family.

2.
J Child Neurol ; 21(4): 340-1, 2006 Apr.
Article in English | MEDLINE | ID: mdl-16900934

ABSTRACT

Transcranial stab wounds are uncommon among both adults and adolescents and rarely occur in children, particularly when caused by another child. A 20-month-old girl was injured by a 3-year-old cousin, who introduced a knife blade into the brain through the left parietal region. The trajectory of the wound penetrated at least 5 cm, crossed the falx cerebri, and involved both motor cortical areas. The clinical sequela was a severe symmetric spastic diplegia.


Subject(s)
Head Injuries, Penetrating/etiology , Muscle Spasticity/etiology , Anti-Dyskinesia Agents/therapeutic use , Botulinum Toxins/therapeutic use , Ecuador , Female , Humans , Infant , Magnetic Resonance Imaging , Manipulation, Orthopedic , Muscle Spasticity/therapy , Paraplegia/etiology , Physical Therapy Modalities
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