[Changes in the processes of lipid peroxidation and of the antioxidant system in female workers in pharmacies]. / Izmenenie protsessov perekisnogo okisleniia lipidov i antioksidantnoi sistemy u rabotnits aptek.

The action of a complex of medicinal compounds on the organism of female pharmacists brings about activation of processes of lipid peroxidation. A relatedness has been found out of degree of changes to character of the illness and age. Those pharmacists with a history of drug allergy show the greatest changes, which fact might provide a basis for forming a risk group of the above workmen.

[Lipid peroxidation in the liver microsomes--a sensitive link in body exposure to vat dyes]. / Perekisnoe okislenie lipidov v mikrosomakh pecheni--chuvstvitel'noe zveno vozdeistviia na organizm nekotorykh kubovykh krasitelei.

Experiments on male white rats showed that the soluble forms of vat dyes such as red brown 'G' (RBG) and bright green 'G' (BGG) delivered into the stomach in a toxic dose (1 g/kg) activate lipid peroxidation (LPO) in liver microsomes. Chronically inhaled dyes hasten of slow down some LPO stages, the changes depending on the concentration, duration of exposure and chemical structure of a compound. Soluble vat dye RBG increases LPO in concentration 5 mg/m3 whereas RBG shows antioxidant action in high and low concentrations.