Correction of endothelial dysfunction with impaza preparation in complex with enalapril and losartan during modeling of NO deficiency.

Modeling of NO deficiency by administration of L-NAME to rats led to the development of arterial hypertension and endothelial dysfunction. Pronounced endothelium and cardioprotective effects of impaza under these experimental conditions manifested more markedly during combined administration of the preparation with standard hypotensive preparations enalapril and losartan.

Comparative study of potential endothelioprotectors and impaza in modeled nitric oxide deficiency.

Experimental NO deficiency induced by L-NAME injection led to the development of arterial hypertension, endothelial dysfunction, and cardiomyocyte hypertrophy and reduced blood content of nitrates and nitrites. Impaza, NO donors, activators of NO-synthase, antioxidants, and antihypertensive preparations produced endothelium-protective effect of different degree.

[Pharmacological correction of experimental chronic limb ischemia].

In tests on a group of 250 rats, we studied (i) the level of microcirculation in the muscles of a healthy limb in the norm and (ii) the dynamics of microcirculation for 6 h after treatment with pentoxifylline in a dose of 60 mg/kg dose and L-arginine in a dose of 30 and 200 mg/kg. The chronic ischemia was modeled by excision of basic femoral artery. There was no significant difference in pentoxyfilline-treated animals in comparison to the control. In the group treated with L-arginine in a dose of 30 mg/kg, a significant increase in microcirculation was observed on the 28-th day of experiment. In the group treated with L-arginine in a dose of 200 mg/kg, there was an increase of microcirculation in all terms of the experiment in comparison to the control. The results of laser doppler flow measurements are correlated with the results of morphological investigation.

Effect of antioxidants pQ510 and resveratrol on regulatory function of the endothelium in rats with modeled arterial hypertension.

We studied the effects of antioxidants resveratrol and pQ510 on physiological parameters and the state of endothelial NO-synthase as a marker of the regulatory function of the endothelium in the aorta of rats with modeled arterial hypertension. The antioxidants promoted recovery of stable NO metabolites in rat serum and maintained expression of endothelial NO-synthase at a normal level. These effects were confirmed by correction of blood pressure and endothelium-dependent vascular dilation assessed by endothelial dysfunction coefficient.

[The effect of the synthetic antioxidant emoxypine on the tonus of the coronary vessels]. / Vliianie sinteticheskogo antioksidanta émoksipina na tonus koronarnykh sosudov.

Intracoronary administration of emoxypine caused the dose-dependent increase in the average coronary blood flow without changing the parameters of cardiohemodynamics. Emoxypine failed to change the structure of the phase coronary blood flow. When administered at the concentration of 5.10(-4)M emoxypine increased the volume rate of the perfusate outflow from the rat isolated heart cavities and decreased the value of potassium contracture of isolated segments of the coronary vessels. The data obtained indicate the direct coronarolytic action of emoxypine.