[Potassium cyanate modification of the toxic and mutagenic effects of gamma radiation and benzo(a)pyrene]. / Modifikatsiia tsianatom kaliia toksicheskikh i mutagennykh éffektov gamma-izlucheniia i benzo(a)pirena.

In experiments with CHO-AT3-2 cell culture, a study was made of the effect of potassium cyanate (KNCO) on the effect of gamma radiation and benzo(a)pyrene (BP) by the following tests: cell viability, induction of cells with micronuclei and fragmented nuclei and mutations by thymidine kinase (TK) and Na+/K+-ATPase loci. Some tests have revealed the increase in the effect of gamma radiation and BP produced by potassium cyanate. It is suggested that the sensitizing effects are related to repair system inhibition and/or changes in the cell chromatin structure produced by KNCO.