Application of Focal Photoinduced Thrombosis for Modeling Spinal Cord Ischemia.

Typical ischemic damage to neurons were detected in the focus of experimental photothrombosis and in the transition zone. They were associated with symptoms of impaired motor functions and dysfunction of pelvic organs. The applied method of focal photothrombosis can be used for simulation of spinal cord ischemia for the development of methods for pharmacological correction and restoration of impaired sensorimotor functions.

Morphological Changes in the Thymus of Newborn Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during the Prenatal Period.

The structure of the thymus in newborn rats exposed in utero to endocrine disruptor DDT was studied. We found that exposure to low doses of DDT during pregnancy does not disturb thymus formation in the offspring, but leads to changes in its structure than manifested as slower lobulation, wider epithelium-free areas in the cortex, and lower number of thymic corpuscles in the medulla. The results attest to sensitivity of the reticuloepithelial stroma of the thymus to the effects of endocrine disruptor.

Histo- and cytoarchitectonics of the hippocampus in young rats injected with propofol and mexidol.

Light microscopic examination of the hippocampus was carried out in young rats (intact and injected with propofol and mexidol according to different protocols). Propofol had a negative effect on hippocampal neurons causing an almost 2-fold increase in the count of modified cells in comparison with the normal level. Mexidol effectively corrected these shifts.

[Structural-functional rearrangement in the thalamic relay nuclei during sensory deficit]. / Strukturno-funktsional'nye perestroiki v releinykh iadrakh talamusa v usloviiakh sensornogo defitsita.

Experiments in adult cats surviving five days, four months and one year after neurosurgical section of the optical tract, half of the midbrain tegmentum, show the stability of cytoarchitectonic organization of LGB and ventro-basal nuclear complex of the thalamus due to ultrastructural plastic rearrangement of the studied neural centers and alterations in the sensory system as a whole.

[Extra-lemniscal afferent projections of dorsal spinal cord nuclei to the ventrobasal nuclear complex structure in the contralateral optic thalamus]. / Ekstralemniskovye afferentnye proektsii iader dorsal'nykh spinnogo mozga na struktury ventrobazal'nogo iadernogo kompleksa kontralateral'nogo zritel'nogo bugra.

It has been found that section of half the midbrain tegmentum in cats failed to prevent the afferent somatosensory projections from the foreleg to the ventrobasal nuclear complex of the contralateral thalamus. Specific evoked responses to the stimulation of the contralateral foreleg were recorded in this structure. These specific EP have the same latency as "lemniscal responses" (4-5 ms) and diminish the amplitude and duration of both components of the responses. Simultaneously, we have observed terminal axonal degeneration into the ventrobasal nuclear complex of the thalamus 5-7 days after the section of the contralateral midbrain tegmentum, using the electron microscopy method. All the results obtained indicate that the dorsal column nuclei have extra-lemniscal afferent connections with ventrolateral nuclear complex of the contralateral thalamus. These connections ascend in the back parts of the brainstem ipsilaterally to the corresponding pair of the dorsal column nuclei and rostrally to the midbrain on the contralateral side.