ABSTRACT
The histochemical behaviour of succinic dehydrogenase, isocitric dehydrogenase, acid phosphatase and acetylglucosaminidase activities was studied in rat liver treated with Au198-colloidal. In these experimental conditions it was found that the hepatocytes present changes in the enzymatic activities examined, generally proportional to the doses employed. With lower doses of radionuclides, the histoenzymatic changes have a local character and are completely reversible after a month. With higher doses they take on a more extensive character. These findings suggest that Au198 could be used clinically with due precautions.
Subject(s)
Acetylglucosaminidase/metabolism , Acid Phosphatase/metabolism , Hexosaminidases/metabolism , Isocitrate Dehydrogenase/metabolism , Liver/enzymology , Succinate Dehydrogenase/metabolism , Animals , Dose-Response Relationship, Radiation , Gold Colloid, Radioactive , Liver/radiation effects , RatsSubject(s)
Acetylglucosaminidase/metabolism , Adenosine Triphosphatases/metabolism , Amino Acids, Sulfur/pharmacology , Chlormerodrin , Dimercaprol/therapeutic use , Hexosaminidases/metabolism , Kidney Diseases/prevention & control , Kidney/radiation effects , Mercury Radioisotopes , Phosphoric Monoester Hydrolases/metabolism , Radiation Injuries, Experimental/prevention & control , Tiopronin/pharmacology , Animals , Kidney/enzymology , Kidney Diseases/enzymology , Radiation Injuries, Experimental/enzymology , RatsSubject(s)
Acetylglucosaminidase/metabolism , Adenosine Triphosphatases/metabolism , Chlormerodrin , Cysteamine/therapeutic use , Cysteine/therapeutic use , Hexosaminidases/metabolism , Kidney Diseases/prevention & control , Kidney/radiation effects , Phosphoric Monoester Hydrolases/metabolism , Radiation Injuries, Experimental/prevention & control , Animals , Kidney/enzymology , Kidney Diseases/enzymology , Radiation Injuries, Experimental/enzymology , RatsSubject(s)
Hypothalamo-Hypophyseal System/metabolism , Receptors, Adrenergic/drug effects , Adrenergic alpha-Antagonists/metabolism , Adrenergic alpha-Antagonists/pharmacology , Adrenergic beta-Antagonists/metabolism , Adrenergic beta-Antagonists/pharmacology , Animals , Male , Microscopy, Fluorescence , Nerve Endings/metabolism , Neurons/metabolism , RatsABSTRACT
The histochemical behaviour of alkaline phosphatase, adenosintriphosphatase, acid phosphatase and acetylglucosaminidase activities was studied in rat kidney treated with Chloromeridrin Hg. In these experimental conditions it was found that the nephrocytes in the proximal convoluted tubule present changes in the enzymatic activities examined, generally proportional to the doses employed. With lower doses of radionuclides, the histoenzymatic changes have a local character and are completely reversible after a month. With higher doses they take on a more extensive character and persis to some extent one month after treatment. These findings suggesti that Hg could be used clinically with due precautions.
