ABSTRACT
Studies of in vivo recovery, longevity and dose response of factor VIII following infusions of a new factor VIII concentrate (Koate, Cutter Laboratories) yielded results similar to those reported using other sources of factor VIII. Koate has been demonstrated to be clinically effective in classic hemophilia. This preparation was produced by refinements of the methods first described by Hershgold, Pool and Pappenhagen in 1966. By these procedures a high purity factor VIII concentrate is obtained being some 65 to 170 fold purified. This factor VIII concentrate was clinically evaluated in 11 hemophilic children (one of them with 7 Bethesda Units inhibitor) who received a total of 13 separate infusions. Biologic half-life values determined in two subjects resulted 12 and 9,5 hours comparing favorably with those previously reported. Initial 50% disappearance averaged 5,4 and 4,8 hours respectively. In vivo recovery of the infused factor VIII activity averaged 98 +/- 12,75%. Dose response measurements showed that 1 unit/Kg gave an in vivo increase in circulating activity of 1,97 +/- 0,93%.
Subject(s)
Factor VIII/therapeutic use , Hemophilia A/drug therapy , Child , Child, Preschool , Clinical Trials as Topic , Dose-Response Relationship, Drug , Drug Evaluation , Factor VIII/metabolism , Hemophilia A/metabolism , Humans , Infant , MaleABSTRACT
Much has already been written about training courses for home care of the hemophiliac held both in Italy and abroad. The advantages of home care are unquestionable. On one hand, the disorder becomes less hospital-dependent, and on the ofter, trough greater partecipation both the infusor and family become more responsible and competent on dealing with it. Hemophilia is a disease which puts the heaving burden on the pediatrics years. A specialized pediatric center is undoubtedly ideal for providing "global" assistance to the hemophilic child and his family so as to prevent any physical consequence of the disorder. There is a natural setting for training courses for home care for parents where they receive proper instruction with respect to problems that are often solely pediatric. The purpose of the course is not just to teach how to reconstitute and infuse freeze-dried concentrate, a practice which is, in itself, fairly easy, but also to give the parents through explanation, and a chance to meet with other parents to exchange ideas and experience.
Subject(s)
Blood Transfusion , Hemophilia A/therapy , Home Nursing/education , Parents , Adult , Child , Curriculum , Evaluation Studies as Topic , Humans , MaleABSTRACT
A statistical research has been carried on 334 pregnant women considering the variation of leucocyte number and leucocyte formula beginning from the 2nd month on. The resulting variations either of the leucocyte number or their formula structure might favour etiological researches for a better understanding of the deep changes caused by pregnancy. These variations refer also to blood group (ABO) and Rh (D) factor.
