ABSTRACT
BACKGROUND: Imatinib mesylate (Gleevec) is a selective Bcr-Abl protein tyrosine-kinase inhibitor, and it also inhibits the receptor tyrosine kinases for stem cell factor (c-kit) and platelet-derived growth factor (PDGFR). It is being investigated for use in the treatment of sclerosing dermatoses. OBSERVATION: A 44-year-old woman with a history of chronic myelogenous leukemia (CML) was referred for the evaluation of a pruritic eruption that developed over 6 months. Examination revealed atrophic plaques confined to the groin, vulva, axillae, inframammary region, trunk, antecubital and popliteal fossae, and posterior thighs bilaterally. A biopsy showed lichen sclerosus et atrophicus (LSetA). At the time of presentation, the patient was receiving imatinib mesylate 400 mg daily for CML. CONCLUSION: This is the first report of development of LSetA, a sclerosing dermatosis, while receiving a therapeutic dose of imatinib mesylate, a drug thought to have anti-sclerotic properties.
Subject(s)
Leukemia, Myeloid/drug therapy , Lichen Sclerosus et Atrophicus/pathology , Piperazines/adverse effects , Pyrimidines/adverse effects , Adult , Antineoplastic Agents/adverse effects , Benzamides , Female , Humans , Imatinib Mesylate , Lichen Sclerosus et Atrophicus/etiologyABSTRACT
BACKGROUND: Contact dermatitis of the eyelids is the most common cutaneous reaction that affects the eyelids. It is frequently caused by the cosmetics used on face, hair, and fingernails. Rarely, eyelid contact dermatitis can be caused by direct contact with either irritant or allergen. OBJECTIVE: To report a case of severe eyelid dermatitis caused by swimming goggles. METHODS: Patch skin tests were performed in duplicate using a small piece of black rubber foam padding from the swimming goggles. Allergy skin prick tests for inhalant aeroallergens were also performed. RESULTS: The results of the patch skin tests were strongly positive. The results of allergy skin prick tests for inhalant aeroallergens were positive for both seasonal and perennial aeroallergens. CONCLUSIONS: This case illustrates that sensitization to the black, foam rubber padding on swimming goggles can occur after long-term contact with the goggles and should be considered in the differential diagnosis of eyelid dermatitis in an appropriate setting.
