Psychosomatic interactions in kidney transplantation: role of personality dimensions in mental health-related quality of life.

BACKGROUND AND AIMS: The increase in innovative and personalized medicine solutions in kidney surgery can improve patients' chances of survival; however, during the transplantation process, patients are exposed to many psychological challenges. This study aimed to evaluate the role and impact of personality dimensions on the behaviour of waiting-list patients towards the post-surgery adaptation process. METHOD: The participants were 113 out-patients aged 18-70 years (mean age 54.7 years, SD ± 9.9) who had received a kidney transplant at least 3 years prior to the study. RESULTS: The results of the study revealed that personality dimensions can predict mental health-related quality of life after kidney transplantation; in particular, the dimensions play an important role in patients' behavioural ability to manage their quality of life both during end-stage renal disease and after kidney transplantation. Psychological distress and anxiety were associated with a low level of the conscientiousness dimension, while a high level of the openness dimension was associated with a high level of psychological distress and stress. In addition, body self-perception was associated with personality dimensions. CONCLUSION: Personality dimensions were found to predict behavioural reactions when emotional traits and body self-perception for each patient were combined; clinical psychologists could apply personalized intervention by modeling the treatments step by step and mitigating the negative effects of the whole kidney transplantation disease, thus helping the individual to adapt to a new life.

Prolonged COVID 19 Outbreak and Psychological Response of Nurses in Italian Healthcare System: Cross-Sectional Study.

Aim of the study was to analyze the posttraumatic stress disorder risk nurses, detecting the relationship between distress experience and personality dimensions in Italian COVID-19 outbreak. A cross-sectional study was conducted based on 2 data detection (March 2020 and September 2020). Mental evaluation was carried out in Laboratory of Clinical Psychology on n.69 nurses in range age 22-64 years old (mean age 37.3; sd ± 10.3; 55% working in nursing care with confirmed COVID-19 patients (named frontline; secondline nurses have been identified by nursing care working with infectious patients but no confirmed COVID-19). Measurement was focused on symptoms anxiety, personality traits, peritraumatic dissociation and post-traumatic stress for all participants. No online screening was applied. Comparisons (ANOVA test) within the various demographic characteristics demonstrated few significant differences between groups on DASS-21, PDEQ, and ISE-R scores. Correlation analysis (Spearman test) was performed among PDEQ, DASS-21, BFI-10 and IES-R and confirmed between anxiety (DASS-21) and peritraumatic dissociation and post-traumatic stress; then anxiety is positively correlated to agreeableness variable of BFI-10 test. The emotional distress was protracted overtime (after 6 months) but in long-term personality traits resulted mediator facing subjective stress. Our finding drew details for protective and predictive risk factors as well as mental health issues of nurses dealing with pandemic: healthcare workers faced the protracted challenge caring COVID-19 patients over and over again: in short time the impact was relevant, and the prolonged exposition to the stressor was tackled by personal resources such as personality traits.

Cognitive Reserve and Digital Confidence among Older Adults as New Paradigm for Resilient Aging.

OBJECTIVE: The purpose of this study was to examine the digital confidence of elder adults and identify behavioral patterns for technology that are related to cognitive abilities among elders. METHOD: An observational study was conducted using a sample of 94 elders, aged 53 to 86 years. Neuropsychological and emotional measures were used, and technology use was assessed. RESULTS: Finding showed elders by resilient neuropsychological aspects can have a good affinity for technology. We examined the role of not only cognitive reserve levels but also demographic characteristics (i.e., age, educational level) and found that elderly were more adherent to digital resources. Technology can be a beneficial resource to those with medium levels of cognitive reserve and make them feel "like they are leading an active lifestyle." CONCLUSIONS: The focal point of our findings is the relevance of cognitive reserve during older adulthood as a key factor that should be examined in investigations on successful aging; it would be more interesting to examine these factors within the context of analyses on the impact of technology on aging and digital living.

[Emotional pattern and body perception: cross-sectional study on risk factors for health management in young women.] / Pattern emotivo e percezione del corpo: studio trasversale sui fattori di rischio per la gestione della salute nelle giovani donne.

INTRODUCTION: The purpose of this study was to investigate the adherence of girls and young adults to socio-cultural beauty models measuring the emotional patterns and behavioral attitudes of self-body management. METHODS: A cross-sectional study was conducted on 2163 Italian women between the ages of 15 and 25 (M=22.2, SD=2.11) distributed by Body Mass Index (BMI), measuring Body Satisfaction and Behaviour. RESULTS: A Multivariate Analysis of Variance (MANOVA) was conducted to examine differences in body satisfaction variables according to BMI and age showed significant effect of BMI group (p=0.001), but there was no effect of age group or an interaction; however significant differences have been evidenced in emotional pattern (p<0.001) and body management (p<0.007), as well as in the overall score for body satisfaction and behaviour (p<0.001). CONCLUSIONS: Results showed that skinny girls feel positively about their weight and shape even if they did not manage to take care of their body adequately. Italian girls prioritize social acceptance rather their own wellness and lifestyle quality. Adherence to the thinness model is a strong risk factor that affects the perceived well-being of girls and young women, regardless of age.

Psychological Barriers to Digital Living in Older Adults: Computer Anxiety as Predictive Mechanism for Technophobia.

This study aimed to investigate the emotional impact of technology use in an Italian adult population and to detect technophobia. This cross-sectional study was conducted with 117 Italian participants (age range of 50-67 years). Measured variables were computer anxiety and technology use ability. The results revealed technophobia features in the Italian adult population related to inadequate management of technology. One-way analysis of variance and Bonferroni's post-hoc analysis showed that non-autonomous (p < 0.01), low-frequency (p < 0.01), and feeling-a-need-for-help users (p < 0.01) had higher levels of computer anxiety. Based on our data, although lifelong learning is a powerful digital need, a considerable proportion of the adult population is not digitally skilled, enlarging the gap between young (native digital) and adult (digital and non-digital adults and seniors) populations. Adult inclusivity in digital living is inadequate and likely affects their quality of life. Thus, our findings highlight technophobia as a possible new risk factor for Italian adults because it can affect their daily life through low adherence to digital living; rather than aging successfully, they could develop fragile aging.

Survivorship in young women after early breast cancer: a cross-sectional study of emotional traits along 3-years perspective.

BACKGROUND: Breast cancer diagnosis and treatments have a strong impact on women's lives. This study aimed to evaluate the changes in emotional traits in women aged 38-50 years over a three-year period. METHOD: By cross-sectional study design, a sample of n. 126 patients in range age 38-50 has been recruited in different timing of cancer disease, in order to evaluate the patients' emotional traits (variables: anxiety, anger, psychological distress, and depression) at the time of diagnosis, and 6, 12, 18, 24, and 36 months after diagnosis. Anger, anxiety, psychological distress, and depression were evaluated. RESULTS: Results showed significant differences in each emotional variable during treatment. Anxiety showed a decreasing trend, whereas anger tended to improve significantly. At 12 and 24 months from the diagnosis, patients seemed more aware about their own psychological needs compared with the period immediately after the diagnosis (T0) and during the treatments. Women who had recently received a diagnosis (T0) seemed more resilient in their responses in facing an emergency. CONCLUSIONS: Increased survival rate after breast cancer diagnosis is strongly linked to the management of emotional weakness of BC women because of modified living. Patients need to be supported to regain their life after clinical treatments though tailored psychological treatment along survivorship, not only in primary treatment.

The Semantic Associative Ability in Preschoolers with Different Language Onset Time.

Aim of the study is to verify the semantic associative abilities in children with different language onset times: early, typical, and delayed talkers. The study was conducted on the sample of 74 preschool children who performed a Perceptual Associative Task, in order to evaluate the ability to link concepts by four associative strategies (function, part/whole, contiguity, and superordinate strategies). The results evidenced that the children with delayed language onset performed significantly better than the children with early language production. No difference was found between typical and delayed language groups. Our results showed that the children with early language onset presented weakness in the flexibility of elaboration of the concepts. The typical and delayed language onset groups overlapped performance in the associative abilities. The time of language onset appeared to be a predictive factor in the use of semantic associative strategies; the early talkers might present a slow pattern of conceptual processing, whereas the typical and late talkers may have protective factors.

Deterioration of semantic associative relationships in mild cognitive impairment and Alzheimer Disease.

The aim of this research was to study semantic abilities and their loss in mild cognitive impairment (MCI) and in dementia, while analyzing efficiency in the use of associative relations, within verbal and visuoperceptual modalities. Participants were split into 4 groups: 19 participants with amnestic MCI, 16 patients with mild Alzheimer disease (AD), 20 patients with moderate AD, and 20 healthy controls (HCs). All participants performed standardized neuropsychological tests and experimental (naming and semantic associations) tasks to evaluate verbal and visuoperceptual semantic abilities. We analyzed 4 associative relations (part/whole, function, superordinate, and contiguity) in both verbal and visuoperceptual code. Our results suggest a progressive impairment in semantic categorization knowledge, with worse performance in the AD groups relative to the MCI and HC groups. Our data show a different pattern in the 4 associative relations and the involvement of associative semantic relations already in the early stage of disease, as well as a different pattern of deterioration between verbal and visuoperceptual modalities. Our data indicate that the visuoperceptual semantic network appears to be less deteriorated than the verbal network in AD. The verbal semantic network may be more sensitive in detecting patients at an early stage of the disease.

The loss of conceptual associations in mild Alzheimer's dementia.

Changes in semantic memory are a controversial topic in research on cognitive decline in aging. In this study, we analyzed whether the semantic deficits in mild Alzheimer's disease (AD) reflect the information acquisition process, and whether the deficits are related to when the information was initially stored. We hypothesized that in the earlier stages of dementia, the ability to access semantic associative relations reflects the use of these associations during different developmental stages. Specifically, we asserted that Alzheimer's patients might be able to access the relations that are learned earlier in life for the longest amount of time compared to those that are learned later. In this study, 254 subjects were divided into four groups (child, adult, senior, and Alzheimer's patients groups) and were evaluated with an experimental semantic association task that incorporated five semantic associative relations that were used to compare performance by age group. An analysis of variance (ANOVA) 4 × 5 test showed a significant main group effect, F(3, 250) = 97.1, p < .001, and an associative relations effect, F(4, 1000) = 23.1, p < .001, as well as an interaction of Group × Associative Relations, F(12, 1000) = 8.5, p < .001. The results demonstrated that the semantic associative relations that were acquired in later developmental stages were less preserved in persons with mild AD (i.e., superordinate relation, p < .0001). On the contrary, the semantic relations acquired earlier in childhood were better preserved in persons with mild AD. Our results suggest that semantic impairment begins with difficulties in using the associative relations that link concepts together in the semantic memory of patients with mild AD dementia (and possibly in individuals with mild cognitive impairment).

Creativity and dementia: a review.

In these last years, creativity was found to play an important role for dementia patients in terms of diagnosis and rehabilitation strategies. This led us to explore the relationships between dementia and creativity. At the aim, artistic creativity and divergent thinking are considered both in non-artists and artists affected by different types of dementia. In general, artistic creativity can be expressed in exceptional cases both in Alzheimer's disease and Frontotemporal dementia, whereas divergent thinking decreases in dementia. The creation of paintings or music is anyway important for expressing emotions and well-being. Yet, creativity seems to emerge when the right prefrontal cortex, posterior temporal, and parietal areas are relatively intact, whereas it declines when these areas are damaged. However, enhanced creativity in dementia is not confirmed by controlled studies conducted in non-artists, and whether artists with dementia can show creativity has to be fully addressed. Future research directions are suggested.

Semantic associative relations and conceptual processing.

We analysed the organisation of semantic network using associative mechanisms between different types of information and studied the progression of the use of these associative relations during development. We aimed to verify the linkage of concepts with the use of semantic associative relations. The goal of this study was to analyse the cognitive ability to use associative relations between various items when describing old and/or new concepts. We examined the performance of 100 subjects between the ages of 4 and 7 years on an experimental task using five associative relations based on verbal encoding. The results showed that children are able to use the five semantic associative relations at age 4, but performance with each of the different associative relations improves at different times during development. Functional and part/whole relations develop at an early age, whereas the superordinate relations develop later. Our study clarified the characteristics of the progression of semantic associations during development as well as the roles that associative relations play in the structure and improvement of the semantic store.

Loss of semantic associative categories in patients with Alzheimer's disease.

Deterioration of semantic memory is one of the primary neuropsychological deficits caused by Alzheimer's disease (AD). In this study, we hypothesize that the breakdown of semantic memory in the mild-to-moderate stage of AD is due to the disruption of the semantic network that links the concepts. Furthermore, the loss of these links is not homogeneous through the semantic association categories (i.e., Superordinate, Contiguity, Part/Whole, Attribute, Function). Twenty-two subjects (11 patients with mild-to-moderate dementia and 11 control subjects matched on demographics) participated in the study. Both controls and patients with AD underwent extensive neuropsychological evaluation and three experimental tasks: (1) Naming Task, (2) Semantic Association Task, and (3) Semantic Knowledge Task. Results showed that: (1) The AD group was significantly different from the normal controls group in all the experimental tasks; (2) the Semantic Association Task was significantly worse than the other tasks; (3) for the AD group, the scores of the Function and Part/Whole association categories were higher than in the other categories; and (4) living stimuli were more impaired than nonliving. These data confirm prior research showing the semantic association is differently impaired in AD patients.

Callosal atrophy in mild cognitive impairment and Alzheimer's disease: different effects in different stages.

Alzheimer's Disease (AD) is a neurodegenerative disorder that mainly affects grey matter (GM). Nevertheless, a number of investigations have documented white matter (WM) pathology associated with AD. The corpus callosum (CC) is the largest WM fiber bundle in the human brain. It has been shown to be susceptible to atrophy in AD mainly as a correlate of Wallerian degeneration of commissural nerve fibers of the neocortex. The aim of this study was to investigate which callosal regions are affected and whether callosal degeneration is associated with the stage of the disease. For this purpose, we analyzed high-resolution MRI data of patients with amnesic mild cognitive impairment (MCI) (n=20), mild AD (n=20), severe AD (n=10), and of healthy controls (n=20). Callosal morphology was investigated applying two different structural techniques: mesh-based geometrical modeling methods and whole-brain voxel-based analyses. Our findings indicate significant reductions in severe AD patients compared to healthy controls in anterior (genu and anterior body) and posterior (splenium) sections. In contrast, differences between healthy controls and mild AD patients or amnesic MCI patients were less pronounced and did not survive corrections for multiple comparisons. When correlating anterior and posterior WM density of the CC with GM density of the cortex in the severe AD group, we detected significant positive relationships between posterior sections of the CC and the cortex. We conclude that callosal atrophy is present predominantly in the latest stage of AD, where two mechanisms might contribute to WM alterations in severe AD: the Wallerian degeneration in posterior subregions and the myelin breakdown process in anterior subregions.