ABSTRACT
This study evaluated the biocompatibility of degradable polydioxanone (PDS) electrospun drug delivery systems (hereafter referred as matrices) containing metronidazole (MET) or ciprofloxacin (CIP) after subcutaneous implantation in rats. Sixty adult male rats were randomized into six groups: SHAM (sham surgery); PDS (antibiotic-free matrix); 1MET (one 25 wt% MET matrix); 1CIP (one 25 wt% CIP matrix); 2MET (two 25 wt% MET matrices); and 2CIP (two 25 wt% CIP matrices). At 3 and 30 days, animals were assessed for inflammatory cell response (ICR), collagen fibers degradation, and oxidative profile (reactive oxygen species [ROS]; lipid peroxidation [LP]; and protein carbonyl [PC]). At 3 days, percentages of no/discrete ICR were 100, 93.3, 86.7, 76.7, 50, and 66.6 for SHAM, PDS, 1MET, 1CIP, 2MET, and 2CIP, respectively. At 30 days, percentages of no/discrete ICR were 100% for SHAM, PDS, 1MET, and 1CIP and 93.3% for 2MET and 2CIP. Between 3 and 30 days, SHAM, 1CIP, and 2CIP produced collagen, while 1MET and 2MET were unchanged. At 30 days, the collagen fiber means percentages for SHAM, PDS, 1MET, 1CIP, 2MET, and 2CIP were 63.7, 60.7, 56.6, 62.6, 51.8, and 61.7, respectively. Antibiotic-eluting matrices showed similar or better oxidative behavior when compared to PDS, except for CIP-eluting matrices, which showed higher levels of PC compared to SHAM or PDS at 30 days. Collectively, our findings indicate that antibiotic-eluting matrices may be an attractive biocompatible drug delivery system to fight periodontopathogens. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B, 2019.
Subject(s)
Anti-Bacterial Agents/chemistry , Biocompatible Materials/chemistry , Ciprofloxacin/chemistry , Metronidazole/chemistry , Nanocapsules/chemistry , Nanofibers/chemistry , Polydioxanone/chemistry , Animals , Anti-Bacterial Agents/pharmacology , Ciprofloxacin/pharmacology , Drug Liberation , Humans , Male , Metronidazole/pharmacology , Oxidation-Reduction , Prosthesis Implantation , Rats , Reactive Oxygen Species/metabolism , Time Factors , Tissue Engineering , Tissue ScaffoldsABSTRACT
O objetivo deste estudo foi analisar a relação entre os níveis de motivação e satisfação atlética dos atletas de futsal de equipes do Paraná participantes da Liga Nacional. Participaram do estudo 75 atletas (25,31 ± 5,21 anos), todos do sexo masculino, das cinco equipes paranaenses participantes da Liga Nacional de Futsal no ano de 2013, competição mais importante do Brasil. Como instrumentos de pesquisa, utilizou-se a Escala de Motivação para o Esporte (SMS) e o Questionário de Satisfação do Atleta (QSA). Os atletas responderam os questionários de forma individual e a aplicação desses foi realizada de forma coletiva pelos pesquisadores responsáveis, no local de treinamento de cada uma das equipes. Para análise dos dados foi utilizado o teste de Kolmogorov-Smirnov, Friedman, a comparação múltipla das distribuições de médias de todas as ordens e o coeficiente de correlação de Spearman, adotando como nível de signifi - cância p<0,05. Os atletas de futsal demonstram maiores níveis de motivação intrínseca comparativamente às regulações de motivação extrínseca e de amotivação (p<0,05), apresentando níveis moderados e altos de satisfação atlética, destacando principalmente a Dedicação Pessoal (Md = 6,00; IQR=1,25), Treino Instrução (Md = 5,33; IQR=1,66) e Ética (Md = 5,67; IQR=1,00). Ainda, as dimensões Utilização de Habilidades, Contribuição da Equipe para o Social, Dedicação Pessoal e Diretoria Médica se correlacionaram positivamente com todas as Motivações Intrínsecas (0,26 ≤ r ≤ 0,40) (p<0,05). Conclui-se que os atletas de futsalparanaense são autodeterminados e satisfeitos para a prática do esporte, evidenciando que a motivação intrínseca está associada com o relacionamento social das equipes e o aperfeiçoamento individual dos atletas....(AU)
This study aimed to analyze the relationship between motivation levels and athletic satisfaction of Paraná futsal teams participating in National League. Participated 75 athletes (25,31 ± 5,21 years old) of the fi ve teams from Paraná participating in the National Futsal League on 2013, the most important competition in Brazil. The Sports Motivation Scale (SMS) and the Athlete Satisfaction Questionnaire were applied. For data analysis the Kolmogorov-Smirnov test, Friedman, the multiple comparison of mean distributions of all orders and the Spearman correlation (p<0,05) were performed. The futsal athletes demonstrate higher levels of intrinsic motivation when compared to all the regulations of extrinsic motivation and demotivation (p<0,05). They presented moderate and high levels of athletic satisfaction, especially Personal Dedication (Md=6,00; IQR=1,25), Training Instruction (Md=5,33; IQR=1,66) and Ethic (Md=5,67; IQR=1,00). In addition, the Skills Utilization, Social Team Contribution, Personal Dedication and Medical Board dimensions are positively correlated with all Intrinsic Motivations (0,26 ≤ r ≤ 0,40) (p<0,05). It is concluded that futsal athletes of Paraná are self-determined and satisfi ed for sport practice, evidencing that intrinsic motivation is associated with the teammate social relationship and the athletes' individual improvement....(AU)
