Subject(s)
Humans , Aged , Analgesics , Anti-Inflammatory Agents , Exercise , Exercise Therapy , Osteoarthritis , Rheumatic DiseasesABSTRACT
To determine the role of scintigraphy in the detection of skeletal and cardiac involvement in dermato- and polymyositis (DM/PM), we studied 30 patients with a confirmed diagnosis of DM/PM (23 females, 7 males; mean age: 35 years). Technetium-99m pyrophosphate (99mTc-PYP) and gallium-67 scans showed similar sensitivity, specificity and accuracy in the detection of skeletal muscle involvement when compared with serum enzymes (70%, 100% and 80%, respectively). Compared with the clinical parameters, 99mTc-PYP showed 70% and 67Ga 65% accuracy. Abnormal PYP cardiac uptake was observed in 57% of patients, whereas abnormal 67Ga cardiac uptake was seen in only 15%. Electrocardiography was abnormal in 40%, rest gated blood pool study in 23%, and chest X-ray in 13%. In conclusion, both 99mTc-PYP and 67Ga can be useful in the detection of the active phase of muscle disease. However, 99mTc-PYP seems to be more effective than 67Ga in the early diagnosis of cardiac involvement.
Subject(s)
Dermatomyositis/diagnostic imaging , Heart/diagnostic imaging , Muscle, Skeletal/diagnostic imaging , Polymyositis/diagnostic imaging , Adolescent , Adult , Child , Clinical Enzyme Tests , Dermatomyositis/diagnosis , Electrocardiography , Female , Gallium Radioisotopes , Gated Blood-Pool Imaging , Humans , Male , Middle Aged , Polymyositis/diagnosis , Predictive Value of Tests , Sensitivity and Specificity , Technetium Tc 99m PyrophosphateABSTRACT
Nonsteroidal anti-inflammatory drugs (NSAID) comprise an important class of medicaments that reduced the symptoms of inflamation in rheumatic disease. This article emphasizes similarities and class characteristics of the NSAID, mechanisms of action, and drug-interactions.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Rheumatic Diseases/drug therapy , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Drug InteractionsABSTRACT
The osteoarthrosis is a disease of high incidence in the population affecting chiefly middle-aged women. The chronic pain is the main cause of incapacity and may be responsible for the secondary articular alterations in theses patients. This paper reviews the physiopathology and the treatment of the pain in osteoarthrosis.
Subject(s)
Osteoarthritis/rehabilitation , Physical and Rehabilitation Medicine , Female , Humans , Male , Middle Aged , Osteoarthritis/physiopathology , Pain/physiopathology , Pain/rehabilitation , PregnancySubject(s)
HLA Antigens/analysis , Lupus Erythematosus, Systemic/immunology , Adolescent , Adult , Child , Female , Gene Frequency , Genetic Markers , HLA-A Antigens , HLA-B Antigens , Heterozygote , Humans , Kidney Diseases/genetics , Kidney Diseases/immunology , Lupus Erythematosus, Systemic/genetics , Male , Middle AgedABSTRACT
Relatamos o caso do paciente do sexo masculino, de 27 anos, com urticaria cronica como manifestacao de vasculite necrosante cutanea, associada a artrite, febre, emagrecimento e hipocomplementemia. A sindrome caracterizada neste paciente e semelhante aos casos previamente relatados como "vasculite hipocomplementemica", "vasculite necrosante associada a urticaria cronica" e "vasculite urticariforme". Apresentamos revisao de literatura e discussao do diagnostico diferencial e tratamento. Acreditamos que essa nova sindrome constitui uma subpopulacao distinta de patologia colageno-vascular
Subject(s)
Adult , Humans , Male , Urticaria , Vasculitis, Leukocytoclastic, Cutaneous , Diagnosis, DifferentialABSTRACT
Foram estudados 30 pacientes (Grupo I) portadores de lupus eritematoso sistemico (LES)que obedeceram ao criterio da Arthritis Rheumatism Association (ARA) dos quais 18 apresentavam diferentes graus de lesao renal verificada atraves de puncao-biopsia e da pesquisa de imunocomplexos pela imunofluorescencia no material obtido pela biopsia renal. Realizou estudo estatistico das frequencias genicas e antigenicas dos antigenos de histocompatibilidade no Grupo I comparando-se com os resultados obtidos no Grupo Controle (Grupo II) constituido por 95 individuos normais, em geral doadores de sangue, na tentativa de se identificar a presenca de um marcador genetico, assim como a possibilidade de associacao dos antigenos HLA com nefropatia lupica. A analise das frequencias antigenicas em nosso trabalho nao demonstrou associacao positiva entre os antigenos de histocompatibilidade dos loci A e B e o lupus eritematoso sistemico, entretanto ressalta-se a presenca do HLA-Aw36 (x=9,71) e a maior frequencia do HLA-Bw35 (x = 2,52)
Subject(s)
Child , Adolescent , Adult , Middle Aged , Humans , Male , Female , HLA Antigens , Lupus Erythematosus, SystemicSubject(s)
Peripheral Nervous System Diseases/etiology , Polyarteritis Nodosa/complications , Adult , Aged , Female , Humans , Male , Middle AgedABSTRACT
E relatado o comprometimento do sistema nervoso em 15 pacientes com poliarterite nodosa. E destacada a mononeurite multipla como a sindrome neurologica mais frequente. E discutida a etiopatogenia das lesoes do sistema nervoso
Subject(s)
Neurologic Manifestations , Polyarteritis Nodosa , Peripheral NervesABSTRACT
Mulher de 52 anos de idade, com sindrome seca iniciada ha seis anos, desenvolveu miastenia grave generalizada moderada. Sao discutidas as associacoes de doencas imunologicas e miastenia grave sendo enfatizadas as possibilidades fisiopatologicas dessas interacoes e em especial a ocorrencia da sindrome de Sjogren (SS) e miastenia grave
Subject(s)
Middle Aged , Humans , Female , Myasthenia Gravis , Sjogren's SyndromeSubject(s)
Osteoarthropathy, Primary Hypertrophic/diagnosis , Adult , Diagnosis, Differential , Hand/diagnostic imaging , Hand Deformities, Congenital , Humans , Limb Deformities, Congenital , Male , Osteoarthropathy, Primary Hypertrophic/diagnostic imaging , Osteoarthropathy, Primary Hypertrophic/genetics , Radiography , Ulna/diagnostic imagingABSTRACT
Polymyositis marked the clinical onset of Chagas's disease in a patient with rheumatoid arthritis. This is unusual, although clinically unimportant muscle involvement in trypanosomiasis has been described. The plasma cell infiltrate and vascular deposition of IgM and C3 suggest that the humoral immune system may play a role in the pathogenesis of chagasic polymyositis. It is not known whether the rheumatoid diseases predisposed to the polymyositis.
