ABSTRACT
Spanish Royal Legislative Decree 1/2015 of July 24 considered radiopharmaceuticals to be drugs subject to current legislation on this matter. After Radiopharmaceuticals are prepared in Radiopharmacy Departments, they are administered to patients to observe alterations or their abnormal distribution in the body depending on the pathology. Unlike conventional drugs, radiopharmaceuticals rarely cause adverse reactions: however, when they do occur, they often cause alarm both to the patient and health care staff. They are typically administered to patients only once or a limited number of times. Most adverse reactions to radiopharmaceuticals are mild and require minimal or no treatment. Such reactions, although rare, can occur, and include sensitivity reactions with systemic symptoms. In general, the most common adverse reactions to radiopharmaceuticals are the following: nausea, dyspnea, bronchospasm, decrease in blood pressure, itching, flushing, hives, chills, cough, bradycardia, muscle cramps, and dizziness. The incidence of reported adverse reactions to radiopharmaceuticals is low. The objective of this review is to describe the most common published adverse reactions to diagnostic or therapeutic radiopharmaceuticals and their characteristics.
El Real Decreto Legislativo 1/2015, de 24 de julio, consideró los radiofármacos como medicamentos sometidos a la legislación vigente en esta materia. Los radiofármacos, una vez preparados en las unidades de radiofarmacia, son administrados a un paciente para observar las alteraciones o su distribución anormal. A diferencia de los fármacos convencionales, los radiofármacos raramente provocan reacciones adversas; sin embargo, cuando ocurren, suelen causar alarma tanto al paciente como al personal sanitario, además son administrados a los pacientes una sola vez o un número limitado de veces. La mayoría de las reacciones adversas a radiofármacos son leves y requieren tratamiento mínimo o no lo requieren. Dichas reacciones, aunque raras, pueden ocurrir, e incluyen reacciones de sensibilidad con síntomas sistémicos. En general, las reacciones adversas a radiofármacos más comunes son: náusea, disnea, broncoespasmo, disminución de la tensión arterial, picor, rubor, urticaria, resfriado, tos, bradicardia, calambres musculares y mareo. La incidencia de reacciones adversas a radiofármacos comunicadas es baja. El objetivo de esta revisión es describir las reacciones adversas a radiofármacos publicadas más comunes y sus características, administrados con fines diagnósticos o terapéuticos.
Subject(s)
Nausea , Radiopharmaceuticals , Humans , Incidence , Radiopharmaceuticals/adverse effectsABSTRACT
Fundamento y objetivo: Se trata de un estudio transversal donde se han determinado los valores de sensibilidad y especificidad del estudio de perfusión miocárdica con 99mTc-Tetrofosmina en protocolo de un día tras estímulo farmacológico con dipiridamol, en una población de mujeres previamente revascularizadas, así como la relación con los territorios vasculares coronarios, tomando como referencia la coronariografía. Pacientes: Se han estudiado con carácter retrospectivo 53 historias clínicas de mujeres sometidas a una prueba de perfusión miocárdica y a una coronariografía de control. Resultados: Los valores de sensibilidad y especificidad para la población fueron de 64,29 por ciento y 75,0 por ciento respectivamente. Por territorio arterial coronario, los valores de sensibilidad y especificidad para la arteria DA fueron de 68,75 por ciento y 75,0 por ciento respectivamente, para la Cx de 37,93 por ciento y 88,89 por ciento, y para la CD de 46,43 por ciento y 60,71 por ciento. Conclusiones: En las mujeres que han sido previamente revascularizadas, la gammagrafía de perfusión miocárdica con 99mTc-Tetrofosmina y dipiridamol en protocolo de un día parece ser una prueba idónea para realizar el seguimiento de pacientes.
Background: This is a cross-sectional study to identify the values of sensitivity and specificity of myocardial perfusion imaging with 99mTc-tetrofosmin one-day protocol after pharmacological stimulation with dipyridamole in a population of women previously revascularized and the relationship of findings to coronary vascular territories, with coronary angiography as a gold standard. Patients We studied retrospectively 53 medical records of women undergoing myocardial perfusion test and control coronary angiography. Results: The sensitivity and specificity for the population were 64.29 percent and 75.0 percent respectively. For coronary artery territory, the values of sensitivity and specificity for the LAD were 68.75 percent and 75.0 percent respectively, for Cx of 37.93 percent and 88.89 percent, and for the RCA 46.43 percent and 60.71 percent. Conclusions: In women who have been previously revascularized, myocardial perfusion scintigraphy with 99mTc-tetrofosmin and dipyridamole in one-day protocol seems to be a suitable test to monitor patients.
Subject(s)
Humans , Female , Organophosphorus Compounds , Organotechnetium Compounds , Heart , Myocardial Perfusion Imaging , Myocardial Revascularization/methods , Coronary Angiography , Heart , Heart , Postoperative Care , Dipyridamole/pharmacology , Cross-Sectional Studies , Exercise Test , Radiopharmaceuticals , Sensitivity and Specificity , Predictive Value of TestsABSTRACT
Fundamento y objetivo: Se trata de un estudio transversal donde se han determinado los valores de sensibilidad y de especificidad del estudio de perfusión miocárdica con 99mTc-tetrofosmina en protocolo de un día tras estímulo farmacológico con dipiridamol en una población de mujeres, así como la relación con los territorios vasculares coronarios, tomando como referencia la coronariografía. Pacientes y método: Se han estudiado con carácter retrospectivo 202 historias clínicas de mujeres con sospecha de cardiopatía isquémica (CI) a las que se les realizó una prueba de perfusión miocárdica y una coronariografía. Resultados: Los valores de sensibilidad y de especificidad para la población fueron del 87,16 y del 81,48%, respectivamente. Por territorio arterial coronario, los valores de sensibilidad y de especificidad para la arteria descendente anterior fueron del 68,75 y del 77,78%, respectivamente; para la coronaria circunfleja fueron del 60,0 y del 81,51%, y para la coronaria derecha fueron del 69,88 y del 72,27%. Conclusiones: La prueba de perfusión miocárdica estimulación/reposo presenta una elevada validez diagnóstica para esta enfermedad en mujeres con sospecha de CI (AU)
Background and objective: This was a cross-sectional study in which the values of sensitivity and specificity of myocardial perfusion study with 99mTc-Tetrofosmina protocol in a day after stimulation with dipyridamole were determined in a population of women. We also assessed the relationship with coronary vascular territories, based on coronary angiography. Patients and method: We studied retrospective medical records of 202 women with suspected ischemic heart disease tested on myocardial perfusion who also underwent coronary angiography. Results: The values of sensitivity and specificity for the population were 87.16% and 81.48% respectively. For the coronary artery territory, the values of sensitivity and specificity for the DA artery were 68.75% and 77.78% respectively, while these were 60.0% and 81.51% for the Cx. Finally, the values for the CD were 69.88 and 72.27%, respectively. Conclusions: The myocardial perfusion test stimulation/rest has a high diagnostic validity for the disease in women with suspected ischemic heart disease (AU)
Subject(s)
Humans , Female , Gamma Rays , Technetium , Myocardial Ischemia , Perfusion/methods , Cross-Sectional Studies , Clinical Protocols , Sensitivity and SpecificityABSTRACT
BACKGROUND AND OBJECTIVE: This was a cross-sectional study in which the values of sensitivity and specificity of myocardial perfusion study with (99)mTc-Tetrofosmina protocol in a day after stimulation with dipyridamole were determined in a population of women. We also assessed the relationship with coronary vascular territories, based on coronary angiography. PATIENTS AND METHOD: We studied retrospective medical records of 202 women with suspected ischemic heart disease tested on myocardial perfusion who also underwent coronary angiography. RESULTS: The values of sensitivity and specificity for the population were 87.16% and 81.48% respectively. For the coronary artery territory, the values of sensitivity and specificity for the DA artery were 68.75% and 77.78% respectively, while these were 60.0% and 81.51% for the Cx. Finally, the values for the CD were 69.88 and 72.27%, respectively. CONCLUSIONS: The myocardial perfusion test stimulation/rest has a high diagnostic validity for the disease in women with suspected ischemic heart disease.
