ABSTRACT
A study involving of 2,000 cases of urethritis revealed the presence of Chlamydia trachomatis in 44% of patients. Following a pathophysiological review, the strongly suggestive clinical picture of infection by this microorganism is emphasized. This study stresses two precise points by dealing with: firstly, the importance of the choice of technique for demonstration of the presence of the bacteria, and its reliability; secondly, the value of bacteriological evidence of the infection in order to treat not only the patient but also the partner(s) and to subsequently confirm the treatment as being effective.
Subject(s)
Chlamydia Infections , Urethritis/etiology , Adult , Bacteriological Techniques , Cells, Cultured , Chlamydia Infections/diagnosis , Chlamydia trachomatis/isolation & purification , Humans , MaleABSTRACT
This study concerns a group of 54 patients with bladder cancer aged from 51 to 80 years (50 males, 4 females). Polyamines (putrescine -PU, spermidine - SPD) were measured on 24 h urine collections prior to surgery by an automatic ion exchange analyzer. Both polyamines, and especially PU, correlated well with the degree of tumor infiltration (JEWETT - MARSHALL stage) and mitotic activity (BROD -ER'S grade). Retrospectively, 28 patients for whom follow-up after surgery was 6 months to one year were classified into two groups: R+ (21) patients with disease recurrence or progression, and R0 (8) patients remaining tumour free. Twenty patients with high preoperative PU levels were in the R+ group. By contrast, 6 patients with normal preoperative PU levels were in the R0 group.
Subject(s)
Polyamines/urine , Urinary Bladder Neoplasms/diagnosis , Follow-Up Studies , Humans , Prognosis , Putrescine/urine , Spermidine/urine , Urinary Bladder Neoplasms/immunology , Urinary Bladder Neoplasms/urineABSTRACT
The polyamines, putrescine (P) and spermidine (S), have been measured in 185 cancer patients. Patients in remission exhibited significantly different levels from those with active disease. In a dynamic patient study, followed over a period of 5-6 months, the urinary polyamine levels correlated closely with the clinical status. Furthermore, polyamines have been measured 24 h before beginning chemotherapy (P1, S1) and 48 h after its onset (P2, S2). The value of the ratio, (S2/P2)/(S1/P1), was found to correlate with the type of response to chemotherapy.
