ABSTRACT
The EPICO (Spanish general registry of COVID-19 in children)-SEHOP (Spanish Society of Pediatric Hematology and Oncology) platform gathers data from children with SARS-CoV-2 in Spain, allowing comparison between children with cancer or allogeneic hematopoietic stem cell transplantation (alloHSCT) and those without. The infection is milder in the cancer/alloHSCT group than in children without comorbidities (7.1% vs. 14.7%), except in children with recent alloHSCT (less than 300 days), of which 35.7% experienced severe COVID-19. These data have been shared with the SEHOP members to support treatment and isolation policies akin to those for children without cancer, except for those with recent alloHSCT or additional comorbidities. This highlights the collaborative registries potential in managing pandemic emergencies.
Subject(s)
COVID-19 , Comorbidity , Hematopoietic Stem Cell Transplantation , Neoplasms , SARS-CoV-2 , Humans , COVID-19/epidemiology , COVID-19/complications , Child , Male , Adolescent , Female , Child, Preschool , Risk Factors , Neoplasms/epidemiology , Neoplasms/therapy , Infant , Spain/epidemiology , Registries , Transplantation, HomologousABSTRACT
This work is aimed to evaluate the nutritional composition, and the techno-functional and in vitro physiological properties of flours made using six different insect species and the sensorial feasibility of including them in bakery products. The insect flours exhibited high protein and fat contents as their main components, highlighting the presence of chitin in ant samples. The techno-functional properties showed high oil holding, swelling, and emulsifying capacities in all the analysed insect flours, whereas their bulk density, hydration properties, and foaming capacity showed average values and no gelation capacity. Moreover, these edible insect flours exhibited effective hyperglycaemia and hyperlipidaemia properties, which together with their high antioxidant capacity are associated with beneficial in vitro physiological effects. The beetle and caterpillar flours stand out in these properties, and thus were selected to make a cupcake. The sensory evaluation confirmed that the edible beetle powder can be successfully included in baked goods to provide excellent sensory properties and very high acceptance. Thus, these insect flours may be of great interest to the food industry as a healthy source of protein, exerting a positive impact on functional and sensory food properties, and with a potential role in the prevention of diseases associated with hyperglycaemia and hyperlipidaemia.
Subject(s)
Edible Insects/chemistry , Nutritive Value , Animals , Antioxidants/chemistry , Ants/chemistry , Chitin/analysis , Coleoptera/chemistry , Dietary Fats/analysis , Dietary Proteins/analysis , Food Handling/methods , Food Industry/methods , Gryllidae/chemistry , Humans , Lepidoptera/chemistry , Locusta migratoria/chemistry , Microscopy, Electron, Scanning/methods , Moths/chemistry , Tenebrio/chemistryABSTRACT
BACKGROUND: Pediatric nonaccidental trauma (NAT) accounts for more than 1500 deaths annually and is a source of incalculable lifelong morbidity. Evidence-based NAT evaluation protocols are available; however, compliance studies are lacking. Here, we analyze the quality of implementation of a new NAT evaluation protocol. METHODS: A review of registry data from a level 3 trauma center was performed for patients with a suspicion of NAT from September 2014 to May 2016. Compliance rates and results of 2 new age-based evaluation protocols were examined before (phase 1) and after (phase 2) a multidisciplinary conference was initiated to improve performance. RESULTS: Seventy-five children underwent evaluation for NAT during the study period. In phase 1, median compliance rates with all of the protocol elements were low (63%). After a bimonthly multidisciplinary conference was initiated, compliance rates improved to 75%. Some elements, which were often missed, were found to be clinically irrelevant. If only clinically relevant elements were included, median compliance in phase 2 is 86%. CONCLUSIONS: Compliance with a new protocol for NAT was improved with the institution of a multidisciplinary conference. Protocol elements, which are shown to be clinically unnecessary, have also been identified and will be eliminated.
Subject(s)
Battered Child Syndrome/diagnosis , Practice Guidelines as Topic , Quality Improvement , Trauma Severity Indices , Child Abuse/diagnosis , Child, Preschool , Female , Guideline Adherence , Humans , Infant , Male , Prospective Studies , Registries , Trauma CentersABSTRACT
Se utilizó la amiodarona en 80 pacientes con síntomas por taquiarritmias rebeldes. Fue efectiva en el 72,2% de los 44 pacientes con taquiarritmias supraventriculares y en el 86,1% de los que sufrían por arritmias ventriculares. Estos pacientes se siguieron durante 18 meses, aunque en 9 no se completó el tiempo de observación. El tiempo medio de comienzo de la efectividad de la droga fue de 7,5 días. Se sugiere que los microputeados en la córnea que comenzaron a detectarse a partir de los primeros 15 días del tratamiento pueden considerarse como un signo de impregnación del medicamento. Se recomienda el empleo de este fármaco en pacientes cuyo tratamiento con otras drogas antiarrítmicas haya fracasado, pues a pesar de su eficacia puede ocasionar diversas reacciones indeseables
Subject(s)
Adult , Middle Aged , Humans , Male , Female , Arrhythmias, Cardiac/drug therapy , Benzofurans/therapeutic use , Benzofurans/adverse effects , Clinical Trials as TopicABSTRACT
Se utilizó la amiodarona en 80 pacientes con síntomas por taquiarritmias rebeldes. Fue efectiva en el 72,2
de los 44 pacientes con taquiarritmias supraventriculares y en el 86,1
de los que sufrían por arritmias ventriculares. Estos pacientes se siguieron durante 18 meses, aunque en 9 no se completó el tiempo de observación. El tiempo medio de comienzo de la efectividad de la droga fue de 7,5 días. Se sugiere que los microputeados en la córnea que comenzaron a detectarse a partir de los primeros 15 días del tratamiento pueden considerarse como un signo de impregnación del medicamento. Se recomienda el empleo de este fármaco en pacientes cuyo tratamiento con otras drogas antiarrítmicas haya fracasado, pues a pesar de su eficacia puede ocasionar diversas reacciones indeseables (AU)
