ABSTRACT
STUDY OBJECTIVE: A multifactor analysis of risk factors for pancreas cancer in women. MATERIAL AND METHODS: A case-control study was conducted in three centres in the Czech Republic (Olomouc, Ostrava, and Ceské Budejovice) in 2006-2009. In total, 226 women (129 pancreas cancer cases, 97 controls) were included in the study. Statistical analysis was performed, the crude odds ratio (OR) was calculated, and logistic regression analysis was used at a 5% level of statistical significance. RESULTS: A statistically significant inverse association was found between pancreatic cancer and oral contraceptives (OR 0.21; 95% CI: 0.07-0.69). Pregnancy and number of pregnancies or gynecological surgical procedures did not show any association with pancreatic cancer. No significant difference in the first menstrual period was found between pancreatic cancer patients and controls. CONCLUSIONS: The study results showed inverse association between pancreatic cancer and oral contraceptives (OR 0.21; 95% CI: 0.07-0.69), controlled alcohol consumption (OR 0.26; 95% CI: 0.12-0.55), and anti-inflamatory drug use (OR 0.10; 95% CI: 0.02-0.41).
Subject(s)
Pancreatic Neoplasms/etiology , Adult , Case-Control Studies , Contraceptives, Oral/administration & dosage , Czech Republic/epidemiology , Female , Humans , Menarche , Middle Aged , Odds Ratio , Pancreatic Neoplasms/epidemiology , Pregnancy , Risk Factors , Sex FactorsABSTRACT
Common alimentary obesity frequently occurs on a polygenic basis as a typical lifestyle disorder in the developed countries. It is associated with characteristic complex metabolic changes, which are the cornerstones for future metabolic syndrome development. The aims of our study were 1) to determine the incidence of metabolic syndrome (based on the diagnostic criteria defined by the International Diabetes Federation for children and adolescents) in Czech obese children, 2) to evaluate the incidence of insulin resistance according to HOMA-IR and QUICKI homeostatic indexes in obese children with and without metabolic syndrome, and 3) to consider the diagnostic value of these indexes for the early detection of metabolic syndrome in obese children. We therefore performed anthropometric and laboratory examinations to determine the incidence of metabolic syndrome and insulin resistance in the group of 274 children with obesity (128 boys and 146 girls) aged 9-17 years. Metabolic syndrome was found in 102 subjects (37 %). On the other hand, the presence of insulin resistance according to QUICKI <0.357 was identified in 86 % and according to HOMA-IR >3.16 in 53 % of obese subjects. This HOMA-IR limit was exceeded by 70 % children in the MS(+) group, but only by 43 % children in the MS(-) group (p<0.0001). However, a relatively high incidence of insulin resistance in obese children without metabolic syndrome raises a question whether the existing diagnostic criteria do not falsely exclude some cases of metabolic syndrome. On the basis of our results we suggest to pay a preventive attention also to obese children with insulin resistance even if they do not fulfill the actual diagnostic criteria for metabolic syndrome.
Subject(s)
Blood Glucose/analysis , Insulin Resistance , Insulin/blood , Metabolic Syndrome/diagnosis , Metabolic Syndrome/epidemiology , Obesity/diagnosis , Obesity/epidemiology , Adolescent , Causality , Child , Comorbidity , Czech Republic/epidemiology , Early Diagnosis , Female , Humans , Incidence , Male , Metabolic Syndrome/blood , Obesity/blood , Population Surveillance , Reproducibility of Results , Risk Factors , Sensitivity and SpecificityABSTRACT
A case report concerning patient diagnosed with a rare carcinoid showing typical symptoms is presented. Although essentially a cancer disease, this condition usually shows slow progression and tends to follow a favorable course with good prognosis if treated properly, assuming patients reasonable compliance. We intend to highlight its typical clinical picture as well as the rarely occurring cardial manifestation leading to rapid progression and ultimately fatal outcome in a non-compliant patient who preferred alternative to evidence based medicine.
Subject(s)
Carcinoid Heart Disease/diagnosis , Humans , Male , Middle AgedABSTRACT
An epidemiological review of the metabolic syndrome is presented. Focus is on history of the discovery of the metabolic syndrome, its definition and changes made to it, etiopathogenesis, incidence and possibility for its prevention by physical activities.
