Search | VHL Regional Portal

1.

Anti-inflammatory activity of 2-acyl-5(3)-hydroxytetrahydro-1H-pyrazole derivatives.

Zelenin, K N; Bezhan, I P; Pastushenkov, L V; Gromova, E G; Lesiovskaja, E E; Chakchir, B A; Melnikova, L F.

Arzneimittelforschung ; 49(10): 843-8, 1999 Oct.

Article in English | MEDLINE | ID: mdl-10554662

ABSTRACT

The anti-inflammatory effects of five pyrazolidine derivatives on white mice and laboratory rats were studied using models of thermal aseptic inflammation and inflammation induced by injection of carragenin and histamine, as well as models of "cotton-ball granuloma" and epinephrine (adrenaline)-induced pulmonary edema. These effects were compared with those of the most commonly used non-steroid anti-inflammatory drugs, such as phenylbutazone (CAS 50-33-9) and diclofenac (CAS 15307-79-6). It was found that the pyrazolidine compounds studied induced a pronounced anti-inflammatory effect by inhibiting both the proliferative and exudative phases of inflammation. At the same time, as compared to natural non-steroid anti-inflammatory drugs, these compounds had a lower toxicity and induced neither gastric ulcers nor suppression of hemopoiesis.

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis , Pyrazoles/chemical synthesis , Animals , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Anti-Inflammatory Agents, Non-Steroidal/toxicity , Blood Cell Count/drug effects , Carrageenan , Edema/chemically induced , Edema/prevention & control , Epinephrine , Exudates and Transudates/cytology , Exudates and Transudates/drug effects , Female , Gossypium , Granuloma/chemically induced , Granuloma/prevention & control , Inflammation/chemically induced , Inflammation/prevention & control , Lethal Dose 50 , Male , Mice , Phenylbutazone/toxicity , Pulmonary Edema/chemically induced , Pulmonary Edema/prevention & control , Pyrazoles/pharmacology , Pyrazoles/toxicity , Rats , Stomach Ulcer/chemically induced , Vasoconstrictor Agents

2.

[Gutimine-induced increased resistance to hypoxia]. / Povyshenie rezistentnosti k gipoksii s pomoshch'iu gutimina.

Vinogradov, V M; Pastushenkov, L V; Sumina, E N.

Patol Fiziol Eksp Ter ; (4): 81-5, 1981.

Article in Russian | MEDLINE | ID: mdl-6793989

Subject(s)

Guanylthiourea/therapeutic use , Hypoxia/prevention & control , Thiourea/analogs & derivatives , Animals , Cats , Cerebrovascular Circulation , Coronary Circulation/drug effects , Dogs , Female , Humans , Hypotension/drug therapy , Hypoxia/metabolism , Hypoxia/physiopathology , Intestinal Pseudo-Obstruction/drug therapy , Ischemia/prevention & control , Labor, Obstetric/drug effects , Microcirculation , Oxygen Consumption , Pregnancy , Rats

3.

[Clinical assessment of Pterophen]. / Opyt klinicheskogo izucheniia pterofena.

Kasalitsa, Ch L; Vinogradov, V M; Pastushenkov, L V; Frolov, S F; Khetagurova, A N.

Klin Med (Mosk) ; 47(10): 62-5, 1969 Oct.

Article in Russian | MEDLINE | ID: mdl-5384606

Subject(s)

Diuretics/therapeutic use , Hypertension/drug therapy , Animals , Dogs , Humans

4.

[Changes in the general status and work capacity under the effect of phenatine during physical load]. / Izmeneniia obshchego sostoianiia i rabotosposobnosti pod vliianiem fenatina pri fizicheskikh nagruzkakh.

Generalov, V I; Krylova, A A; Masiuta, G F; Pastushenkov, L V; Smirnova, S M.

Voen Med Zh ; 6: 52-4, 1969 Jun.

Article in Russian | MEDLINE | ID: mdl-4241137

Subject(s)

Fatigue/prevention & control , Military Medicine , Niacinamide/pharmacology , Adult , Age Factors , Humans , Male , Middle Aged , USSR

5.

[Pharmacological substances increasing resistance to hypoxia. (Review of the literature)]. / Farmakologicheskie sredstva, povyshaiushchie ustoichivost k gipoksii (obzor literatury)

Arbuzov, S Ia; Pastushenkov, L V.

Farmakol Toksikol ; 32(1): 115-20, 1969.

Article in Russian | MEDLINE | ID: mdl-4388894

Subject(s)

Hypoxia/prevention & control , Amphetamine/therapeutic use , Animals , Caffeine/therapeutic use , Cats , Central Nervous System Stimulants/therapeutic use , Dogs , Enzyme Therapy , Ephedrine/therapeutic use , Guinea Pigs , Hormones/therapeutic use , Humans , Hydroquinones/therapeutic use , Methylene Blue/therapeutic use , Mice , Narcotics/therapeutic use , Physostigmine/therapeutic use , Procaine/therapeutic use , Rabbits , Rats , Sulfonamides/therapeutic use , Tranquilizing Agents/therapeutic use , Vitamins/therapeutic use

6.

[Increase of resistance of the myocardium to acute hypoxia by means of gutimine]. / Povyshenie ustoichivosti miokarda k ostroi gipoksii s pomoshch'iu gutimina.

Aleksandrova, A E; Vinogradov, V M; Pastushenkov, L V; Barbulev, B U.

Farmakol Toksikol ; 31(6): 697-700, 1968.

Article in Russian | MEDLINE | ID: mdl-5713580

Subject(s)

Heart Rate/drug effects , Hypoxia/prevention & control , Oxygen Consumption , Thiourea/pharmacology , Animals , Apnea/chemically induced , Blood Glucose/analysis , Brain Chemistry/drug effects , Catecholamines/analysis , Cats , Depression, Chemical , Dogs , Electrocardiography , Glycogen/analysis , Isoproterenol/pharmacology , Lactates/blood , Liver/analysis , Musculoskeletal System/analysis , Myocardial Infarction/chemically induced , Myocardial Infarction/mortality , Myocardial Infarction/prevention & control , Myocardium/analysis , Rabbits , Rats , Succinylcholine , Thiourea/therapeutic use

7.

[Use of electronacceptory properties of hydroquinone for the prevention and therapy of oxygen deficiency]. / Ispol'zovanie élektronaktseptornykh svoistv gidrokhinona dlia profilaktiki i lecheniia kislorodnogo golodamiia.

Vinogradov, V M; Pastushenkov, L V; Frolov, S F.

Farmakol Toksikol ; 31(2): 218-21, 1968.

Article in Russian | MEDLINE | ID: mdl-4386317

Subject(s)

Hydroquinones/therapeutic use , Hypoxia/drug therapy , Action Potentials/drug effects , Animals , Asphyxia/prevention & control , Brain/drug effects , Carotid Arteries/physiology , Cats , Central Nervous System Stimulants/pharmacology , Cyanides/pharmacology , Electroencephalography , Epinephrine/pharmacology , Hydroquinones/pharmacology , Hyperbaric Oxygenation , Hypoxia/prevention & control , Male , Mice , Norepinephrine/pharmacology , Potassium , Rats , Respiration/drug effects , Succinylcholine/pharmacology

8.

[Increasing the resistance of the organism to overload by the use of pharmacological agents]. / Povyshenie ustoichivosti organizma k peregruzkam s pomoshch'iu farmakologicheskikh sredstv.

Pastushenkov, L V.

Voen Med Zh ; 12: 55-6, 1967 Dec.

Article in Russian | MEDLINE | ID: mdl-5605329

Subject(s)

Rotation , Stress, Physiological/prevention & control , Sulfur/therapeutic use , Animals , Male , Mice , Rats

9.

[On the pharmacology of ademine]. / K farmakologii ademina.

Arbuzov, S Ia; Kasalitsa, Ch L; Vinogradov, V M; Pastushenkov, L V; Frolov, S F; Sharanin, Iu A; Murashov, G M.

Farmakol Toksikol ; 30(2): 189-92, 1967.

Article in Russian | MEDLINE | ID: mdl-5599522

Subject(s)

Diuresis/drug effects , Triamterene/pharmacology , Animals , Chlorine/metabolism , Dogs , Hydrochlorothiazide/pharmacology , Kidney/drug effects , Mice , Natriuresis/drug effects , Potassium/metabolism , Rabbits , Rats , Triamterene/toxicity , Water-Electrolyte Balance/drug effects

10.

[Experimental therapy and prevention of acute hypoxia with gutimine]. / Eksperimental'naia terapiia i profilaktika ostroi gipoksii s pomoshch'iu gutimina.

Pastushenkov, L V; Vinogradov, V M.

Patol Fiziol Eksp Ter ; 10(6): 81-2, 1966.

Article in Russian | MEDLINE | ID: mdl-5246531

Subject(s)

Hypoxia/drug therapy , Hypoxia/prevention & control , Urea/therapeutic use , Animals , Cats , Dogs , Mice , Rats

11.

[Pharmacological characteristic of gutimine]. / Farmakologicheskaia kharakteristika gutimina.

Pastushenkov, L V.

Farmakol Toksikol ; 29(6): 725-7, 1966.

Article in Russian | MEDLINE | ID: mdl-6000370

Subject(s)

Guanidines/pharmacology , Hypoxia/prevention & control , Thiourea/pharmacology , Animals , Brain/drug effects , Brain/physiology , Cardiovascular System/drug effects , Carotid Arteries/physiology , Cats , Central Nervous System/drug effects , Conditioning, Classical/drug effects , Dogs , Electrophysiology , Guanidines/toxicity , Mice , Rats , Respiratory System/drug effects , Thiourea/toxicity

ABSTRACT

Subject(s)

Subject(s)

Subject(s)

Subject(s)

Subject(s)

Subject(s)

Subject(s)

Subject(s)

Subject(s)

Subject(s)

Subject(s)

SEND TO:

SELECTION OF CITATIONS

SEARCH DETAIL