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Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1.
Zhang, Xiaoyan; Urbanski, Maud; Patel, Mona; Zeck, Roxanne E; Cox, Geoffrey G; Bian, Haiyan; Conway, Bruce R; Pat Beavers, Mary; Rybczynski, Philip J; Demarest, Keith T.
Bioorg Med Chem Lett ; 15(23): 5202-6, 2005 Dec 01.
Article in English | MEDLINE | ID: mdl-16198559

ABSTRACT

A series of benzo-fused heteroaryl-O-glucosides was synthesized and evaluated in SGLT1 and 2 cell-based functional assays. Indole-O-glucoside 10a and benzimidazole-O-glucoside 18 exhibited potent in vitro SGLT2 inhibitory activity.


Subject(s)
Glucosides/chemistry , Glucosides/pharmacology , Sodium-Glucose Transporter 2 Inhibitors , Glucosides/chemical synthesis , Humans , Molecular Structure
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