[The prognostic value of content of acute phase proteins in development of puerperal endometritis].

The analysis was made of the content of proteins in inflammation acute phase in 100 healthy puerperants and 157 women with endometritis after cesarean section. The established disproportion in protein concentration during acute phase in healthy puerperants is considered as a female organism adaptive reaction to pregnancy and delivery. As for patients with endometritis, this condition testifies the compensatory resources stress, development of pathophysiological reactions of organism and intensity of local damages. The concentration of C-reactive protein and prealbumin in patients with endometritis provides an opportunity to forecast the degree of severity of course of disease.

[Effects of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides on hormonal activity and thyroid morphology in hypophysectomized mature and old birds].

The aim of the paper was to investigate effects of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides which were designed and synthesized on the basis of amino acid study of the hypophyseal anterior and posterior lobe peptides on the thyroid morphology and hormonal activity in mature chicken and old birds. Hypophysectomy was established to produce atrophic changes in the thyroid gland and development of secondary hypothyrosis. Administration of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly tetrapeptides significantly prevented these impairments by increasing the levels of the thyroid-stimulating hormone (TSH) as well as T3 and T4. Restoration of the thyroid functions and morphology was registered to be greater in one-year-old chicken as compared to five-year-old ones.

[Effects of hypophyseal Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly synthetic peptides on immunity, hemostasis, morphology and functions of the thyroid gland in neonatally hypophysectomized chicken and one-year-old birds].

Neonatal hypophysectomy in chicken produces enlarged follicles of the thyroid gland, accumulation of colloids, impressed follicular epithelium, increased nucleus-cytoplasm ratio in thyrocytes, atrophied inter-follicular epithelium, depressed immunity, development of hypercoagulation and depressed fibrinolysis. When hypophysectomy is performed in one-year-old birds the impairments developing in thyroid morphology, immunity and hemostasis are less pronounced. Peptides of the anterior (Lys-Glu-Asp-Gly) and posterior (Ala-Glu-Asp-Gly) thyroid lobes injected to hypophysectomized birds prevent atrophic changes of the thyroid gland, normalize immune and hemostatic parameters.

[Effects of epithalon and cortagene on immunity and hemostasis in neonatally hypophysectomized chicken and old birds].

It has been found that chicken hypophysectomized early in the neonatal period develop anemia, cellular and humoral immune deficiency, hypercoagulation and inhibited fibrinolysis by their 45th postnatal day. An analogous operation performed on old birds produces less significant changes in erythrocytes, immunity and hemostasis. Injections of epithalon tetrapeptide (Ala-Glu-Asp-Gly) administered to either hypophysectomized chicken or old birds during a period of 40 days completely eliminate the shifts registered in erythrocytes, immunity and hemostasis, while injections of cortagene (Ala-Glu-Asp-Pro) which is distinguished from epithalon by a different terminal aminoacid (with Gly being replaced by Pro) do not affect the parameters studied.

[Ontogenetic aspects of morphological and functional characteristics of the thyroid gland in birds].

One can distinguish two most important periods in postnatal ontogenesis of the thyroid gland in birds. On the 5th postnatal day dramatic enhancement of adenohypophyseal endocrine functioning causes thyrocitic activation, which results in elevated levels of the thyroid hormones. The morphological and functional peak of the thyroid gland is within 3-12 months. Old birds manifest reduced production of the thyroid-stimulating hormone and show morphological changes in the parenchyma and stroma of the thyroid gland which eventually result in diminished production of the thyroid hormones.

[Gastric cytomedines effects on immune response in acute immobilization stress in rats].

Effects of gastric cytomedines on repair and immune response were studied in 137 white non-inbred rats. Erosions of gastric mucosa were induced by acute immobilization stress. A decrease in antibody production, titers of hemagglutinins and hemolysins was found on day 2 after stress. Gastric cytomedines in a dose 0.15 mg/kg intramuscularly stimulate immune response (increased production of antibodies, antibody dependent cellular cytotoxicity index, titers of hemagglutinins and hemolysins), fast erosions epithelization and have a protective action.

[Effect of epitalon on the immunity and hemostasis in hypophysectomized chicken and old hens]. / Vliianie épitalona na immunitet i gemostaz u gipofizéktomocheskikh tsypliat i starykh kur.

Neonatal hypophysectomy in chicken, as well as that in old hen has been established to entail in 1,5 months after surgery cellular and humoral immunity disturbances, pronounced hypercoagulation and fibrinolysis depression. Administration of Epitalon (Ala-Glu-Asp-Gly) to a large extent eliminates revealed shifts. This effect appeared to be stronger in neonatally hypophysectomized chicken than in old hens.