Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 11 de 11
Filter
Add more filters










Publication year range
2.
3.
JAMA Dermatol ; 158(10): 1216-1218, 2022 Oct 01.
Article in English | MEDLINE | ID: mdl-35921087

ABSTRACT

This case report describes a woman in her 40s with a 2-week history of abrupt painful ulcerations of the perineum.


Subject(s)
Perineum , Skin Ulcer , Humans , Skin Ulcer/diagnosis , Skin Ulcer/etiology
6.
Clin Liver Dis ; 24(3): 351-360, 2020 08.
Article in English | MEDLINE | ID: mdl-32620276

ABSTRACT

Given the visibility of cutaneous findings, skin manifestations are often a presenting symptom of underlying systemic disease, including chronic liver disease. Many cutaneous signs and symptoms that correlate with chronic liver disease are common physical examination findings in patients with no history of liver disease. It is nonetheless important to be aware that these cutaneous findings may be an indication of underlying liver disease and often occur in the setting of such hepatic dysfunction. This article covers general cutaneous signs that may correlate with various liver diseases and describes specific cutaneous signs as they relate to more specific liver diseases.


Subject(s)
Liver Diseases/complications , Skin Diseases/etiology , Chronic Disease , Erythema/etiology , Hand Dermatoses/etiology , Hemangioma/etiology , Hemochromatosis/complications , Hepatitis B, Chronic/complications , Hepatitis C, Chronic/complications , Humans , Jaundice/etiology , Liver Cirrhosis/complications , Liver Cirrhosis, Biliary/complications , Pruritus/etiology , Skin Neoplasms/etiology , Xanthomatosis/etiology
7.
J Radiol Case Rep ; 14(1): 12-20, 2020 Jan.
Article in English | MEDLINE | ID: mdl-32184930

ABSTRACT

Isolated rupture of the renal pelvis secondary to blunt trauma is rare, though there is increased incidence in the setting of a pre-existing renal abnormality that predisposes the kidney to injury. We report a case of post-traumatic hemorrhage into the renal collecting system leading to delayed rupture of the renal pelvis in the setting of suspected chronic ureteropelvic junction obstruction. This case illustrates the difficulty in diagnosis of acute hemorrhage into the renal collecting system. Special attention should be given to a kidney with a pre-existing abnormality in the setting of trauma to prevent complications. A literature review of hemorrhage into the collecting system along with appropriate imaging and management are discussed.


Subject(s)
Hemorrhage/etiology , Kidney Pelvis/injuries , Rupture/etiology , Ureteral Obstruction/complications , Wounds, Nonpenetrating/complications , Adult , Chronic Disease , Diagnosis, Differential , Fatal Outcome , Hemorrhage/diagnostic imaging , Hemorrhage/surgery , Humans , Kidney Pelvis/diagnostic imaging , Kidney Pelvis/surgery , Male , Rupture/diagnostic imaging , Rupture/surgery , Time , Tomography, X-Ray Computed/methods , Ureteral Obstruction/diagnostic imaging , Wounds, Nonpenetrating/diagnostic imaging , Wounds, Nonpenetrating/surgery
8.
Cancer Med ; 8(5): 2205-2212, 2019 05.
Article in English | MEDLINE | ID: mdl-30950242

ABSTRACT

BACKGROUND: Gene expression profiling (GEP) has been integrated into cancer treatment decision-making in multiple neoplasms. We prospectively evaluated the prognostic utility of the 31-GEP test (DecisionDx-Melanoma, Castle Biosciences, Inc) in cutaneous melanoma (CM) patients undergoing sentinel node biopsy (SNB). METHODS: One hundred fifty-nine patients (age 26-88) diagnosed with melanoma between 01/2013 and 8/2015 underwent SNB and concurrent GEP testing. GEP results were reported as low-risk Class 1 (subclasses 1A and 1B) or high-risk Class 2 (subclasses 2A and 2B). Statistical analyses were performed with chi-square analysis, t tests, log-rank tests, and Cox proportional hazard models. Recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) were estimated using Kaplan-Meier method. RESULTS: Median follow-up was 44.9 months for event-free cases. Median Breslow thickness was 1.4 mm (0.2-15.0 mm). There were 117 Class 1 and 42 Class 2 patients. Gender, age, Breslow thickness, ulceration, SNB positivity, and AJCC stage were significantly associated with GEP classification (P < 0.05 for all). Recurrence and distant metastasis rates were 5% and 1% for Class 1 patients compared with 55% and 36% for Class 2 patients. Sensitivities of Class 2 and SNB for recurrence were 79% and 34%, respectively. Of 10 SNB-positive/Class 2 patients, 9 recurred. By multivariate analysis, only SNB result and GEP class were statistically associated with both RFS (P = 0.008 and 0.0001) and DMFS (P = 0.019 and 0.001). CONCLUSIONS: Gene expression profiling Class 2 result and SNB positivity were independently associated with recurrence and distant metastasis in primary CM patients. GEP testing may have additive prognostic utility in initial staging work-up of these patients.


Subject(s)
Gene Expression Profiling/methods , Gene Regulatory Networks , Melanoma/pathology , Skin Neoplasms/pathology , Aged , Aged, 80 and over , Female , Gene Expression Regulation, Neoplastic , Humans , Male , Melanoma/genetics , Melanoma/mortality , Neoplasm Staging , Prognosis , Prospective Studies , Sentinel Lymph Node Biopsy , Skin Neoplasms/genetics , Skin Neoplasms/mortality , Survival Analysis , Melanoma, Cutaneous Malignant
11.
Contact Dermatitis ; 78(3): 194-198, 2018 Mar.
Article in English | MEDLINE | ID: mdl-29210087

ABSTRACT

BACKGROUND: Methotrexate, a folate antimetabolite, is used to treat atopic dermatitis and psoriasis. Although methotrexate's therapeutic efficacy has been noted in the literature, there are few data on the efficacy of methotrexate treatment for allergic contact dermatitis. OBJECTIVE: To evaluate the efficacy and tolerability of methotrexate in treating allergic contact dermatitis at a single institution, and also to assess methotrexate efficacy in patients with chronic, unavoidable allergen exposure. METHODS: We performed a retrospective chart review of 32 patients diagnosed with allergic contact dermatitis by positive patch test reactions, and who received treatment with methotrexate from November 2010 to November 2014. Demographic and treatment-associated data were collected from electronic medical records. Ten patients were identified as allergen non-avoiders secondary to their occupation, and were subgrouped as such. RESULTS: Seventy-eight per cent (25/32) of patients showed either a partial or a complete response. Methotrexate had a comparable efficacy rate in the allergen non-avoiders subset, at 10 of 10. Of the 32 patients, 23% (5/22) had complete clearance of their dermatitis, and 1/10 of allergen non-avoiders had complete clearance of their dermatitis. CONCLUSION: Methotrexate is a well-tolerated and effective treatment for allergic contact dermatitis, and shows comparable efficacy to immunomodulatory agents such as cyclosporine and azathioprine, with robust efficacy despite persistent allergen exposure in patients with allergic contact dermatitis.


Subject(s)
Dermatitis, Allergic Contact/drug therapy , Dermatitis, Occupational/drug therapy , Immunosuppressive Agents/therapeutic use , Methotrexate/therapeutic use , Occupational Exposure/adverse effects , Dermatitis, Allergic Contact/etiology , Humans , Immunosuppressive Agents/adverse effects , Methotrexate/adverse effects , Patch Tests , Retrospective Studies
SELECTION OF CITATIONS
SEARCH DETAIL
...