ABSTRACT
Corrosive injury to the GI tract still poses great challenges with regards to the initial evaluation triage, as well as the optimization of medical management. Although relatively uncommon in the adult population, these injuries can cause significant morbidity and serious sequelae of complications, such as esophageal strictures and cancer. Prompt recognition of the process and aggressive measures towards the stabilization of the patient are key to a favorable outcome.
Subject(s)
Caustics/adverse effects , Gastrointestinal Diseases/chemically induced , Gastrointestinal Tract/injuries , Adrenal Cortex Hormones/therapeutic use , Anti-Bacterial Agents/therapeutic use , Endoscopy, Gastrointestinal , Gastrointestinal Diseases/diagnosis , Gastrointestinal Diseases/therapy , HumansABSTRACT
Carcinosarcomas are relatively rare tumors composed of both carcinomatous and sarcomatous components. The most common sites involved by this tumor are the head and neck, respiratory tract, uterus, ovaries, and fallopian tubes. Within the gastrointestinal tract this tumor most often occurs in the esophagus, followed by the stomach. Carcinosarcomas are very aggressive tumors associated with a poor prognosis. The first case of carcinosarcoma of the colon was reported in 1986. The case reported here is the only one involving an associated colovesical fistula.
Subject(s)
Carcinosarcoma/complications , Colon, Sigmoid/surgery , Colonic Neoplasms/complications , Intestinal Fistula/etiology , Urinary Bladder Fistula/etiology , Adult , Antineoplastic Agents/therapeutic use , Carcinosarcoma/diagnosis , Carcinosarcoma/therapy , Colectomy , Colonic Neoplasms/diagnosis , Colonic Neoplasms/therapy , Colonoscopy , Diagnosis, Differential , Female , Follow-Up Studies , Humans , Intestinal Fistula/diagnosis , Intestinal Fistula/surgery , Plastic Surgery Procedures/methods , Tomography, X-Ray Computed , Urinary Bladder Fistula/diagnosis , Urinary Bladder Fistula/surgeryABSTRACT
Budesonide is a promising drug for a variety of documented applications and has potential in gastroenterology. Its unique local mechanism of delivery and efficient first-pass metabolism, resulting in fewer systemic adverse effects than with conventional glucocorticoids, makes this a desirable drug for clinical practice. This drug has shown promise in treating a wide spectrum of inflammatory diseases from inflammatory bowel disease and other colitides to autoimmune liver diseases. Future research should focus on ways to increase delivery methods to promote long-term usage for maintenance therapy for the disease entities listed above, as well as for other potential nongastrointestinal conditions.
