ABSTRACT
A spectrofluorimetric method using fluorescent carbon dots (CDs) was developed for the selective detection of azelnidipine (AZEL) pharmaceutical in the presence of other drugs. In this study, N-doped CDs (N-CDs) were synthesized through a single-step hydrothermal process, using citric acid and urea as precursor materials. The prepared N-CDs showed a highly intense blue fluorescence emission at 447 nm, with a photoluminescence quantum yield of ~21.15% and a fluorescence lifetime of 0.47 ns. The N-CDs showed selective fluorescence quenching in the presence of all three antihypertensive drugs, which was used as a successful detection platform for the analysis of AZEL. The photophysical properties, UV-vis light absorbance, fluorescence emission, and lifetime measurements support the interaction between N-CDs and AZEL, leading to fluorescence quenching of N-CDs as a result of ground-state complex formation followed by a static fluorescence quenching phenomenon. The detection platform showed linearity in the range 10-200 µg/ml (R2 = 0.9837). The developed method was effectively utilized for the quantitative analysis of AZEL in commercially available pharmaceutical tablets, yielding results that closely align with those obtained from the standard method (UV spectroscopy). With a score of 0.76 on the 'Analytical GREEnness (AGREE)' scale, the developed analytical method, incorporating 12 distinct green analytical chemistry components, stands out as an important technique for estimating AZEL.
Subject(s)
Azetidinecarboxylic Acid , Carbon , Dihydropyridines , Quantum Dots , Spectrometry, Fluorescence , Dihydropyridines/analysis , Dihydropyridines/chemistry , Carbon/chemistry , Azetidinecarboxylic Acid/analysis , Azetidinecarboxylic Acid/analogs & derivatives , Azetidinecarboxylic Acid/chemistry , Quantum Dots/chemistry , Green Chemistry Technology , Tablets/analysis , Fluorescent Dyes/chemistry , Pharmaceutical Preparations/chemistry , Pharmaceutical Preparations/analysis , Molecular StructureABSTRACT
In the title compound, C25H20O3, the central -C(=O)-C=C- chain is disordered over two positions about the central C atom, with an occupancy ratio of 0.848â (6):0.152â (6). The mol-ecule is twisted with the two naphthalene ring systems being inclined to one another by 52.91â (9)°. In the crystal, mol-ecules are linked by C-Hâ¯π inter-actions, forming a three-dimensional structure. The structure was refined as a two-component twin with a 180 ° rotation about the c* axis.
