ABSTRACT
Using standard and ultrasensitive techniques, we detected nonnucleoside reverse-transcriptase inhibitor-associated resistance mutations in 11 (20%) of 54 subjects who discontinued virologically suppressive nonnucleoside reverse-transcriptase inhibitor-containing antiretroviral therapy. Resistance was detected in 45% and 14% of subjects with a baseline human immunodeficiency virus type 1 RNA level of 51-400 copies/mL and Subject(s)
Drug Resistance, Viral/genetics
, HIV Infections/drug therapy
, HIV-1/drug effects
, Reverse Transcriptase Inhibitors/administration & dosage
, Adult
, Drug Administration Schedule
, Female
, HIV Infections/virology
, HIV-1/genetics
, Humans
, Male
, Mutation/drug effects
, Viral Load
ABSTRACT
Echinococcal disease is infrequently seen in developed countries. In the United States, most cases are imported from endemic areas. Although frequently asymptomatic, enlarging cysts can cause local symptoms. Cysts can rupture spontaneously or as a result of trauma. Optimal management of accidental rupture of echinococcal cysts with little or no symptoms is not well known. The authors describe a case of inadvertent rupture of an echinococcal cyst and review the English literature to determine an acceptable management strategy.
