Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
1.
J Artif Organs ; 13(1): 24-30, 2010 Apr.
Article in English | MEDLINE | ID: mdl-20213454

ABSTRACT

It is widely recognised that the bioprosthetic valves widely used for heart valve replacements have some drawbacks, for example tearing and occurrence of infections, which can be attributed to the fixation and sterilization techniques currently available. These techniques adversely affect the physical properties, functionality, and lifespan of the leaflets. In the work discussed in this paper we examined a novel procedure of using high-frequency microwaves to fix and disinfect the pericardium, without causing any harmful affects. The test bacteria used were Escherichia coli and Staphylococcus aureus. The pericardium was exposed to microwaves at a frequency of 18 GHz for three consecutive replicates. The findings indicated that there was almost complete inactivation of the bacteria on the biomaterial without compromising the biocompatibility, which was studied using ovine fibroblasts. An effective fixation and sterilization procedure, that is quick and has no adverse effects is presented and discussed.


Subject(s)
Bioprosthesis/microbiology , Heart Valve Prosthesis Implantation/methods , Heart Valve Prosthesis/microbiology , Sterilization/methods , Animals , Cattle , Escherichia coli/isolation & purification , Materials Testing , Microscopy, Electron, Scanning , Microwaves , Staphylococcus aureus/isolation & purification , Tensile Strength
2.
Cancer Prev Res (Phila) ; 2(9): 776-81, 2009 Sep.
Article in English | MEDLINE | ID: mdl-19641042

ABSTRACT

The burden of squamous cell carcinoma of the head and neck (SCCHN) is greater for blacks than for whites, especially in oropharyngeal cases. We previously showed retrospectively that disease-free survival was significantly greater in white than in black SCCHN patients treated with chemoradiation, the greatest difference occurring in the oropharyngeal subgroup. Oropharyngeal cancer is increasing in incidence and in its association with human papillomavirus (HPV) infection; HPV-positive oropharyngeal cancer patients have significantly better outcomes (versus HPV-negative). These collective data led to the present analyses of overall survival (OS) in our retrospective cohort and of OS and HPV status (tested prospectively in pretreatment biopsy specimens) in the phase 3, multicenter TAX 324 trial of induction chemotherapy followed by concurrent chemoradiation in SCCHN patients. Median OS in the retrospective cohort of 106 white and 95 black SCCHN patients was 52.1 months (white) versus only 23.7 months (black; P = 0.009), due entirely to OS in the subgroup of patients with oropharyngeal cancer--69.4 months (whites) versus 25.2 months (blacks; P = 0.0006); no significant difference by race occurred in survival of non-oropharyngeal SCCHN (P = 0.58). In TAX 324, 196 white patients and 28 black patients could be assessed for HPV status. Median OS was significantly worse for black patients (20.9 months) than for white patients (70.6 months; P = 0.03) and dramatically improved in HPV-positive (not reached) versus HPV-negative (26.6 months, 5.1 hazard ratio) oropharyngeal patients (P < 0.0001), 49% of whom were HPV-16 positive. Overall, HPV positivity was 34% in white versus 4% in black patients (P = 0.0004). Survival was similar for black and white HPV-negative patients (P = 0.56). This is the first prospective assessment of confirmed HPV status in black versus white SCCHN patients. Worse OS for black SCCHN patients was driven by oropharyngeal cancer outcomes, and that for black oropharyngeal cancer patients by a lower prevalence of HPV infection. These findings have important implications for the etiology, prevention, prognosis, and treatment of SCCHN.


Subject(s)
Black or African American/statistics & numerical data , Carcinoma, Squamous Cell/mortality , Human papillomavirus 16/genetics , Oropharyngeal Neoplasms/mortality , Papillomavirus Infections/mortality , Adult , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/therapy , Carcinoma, Squamous Cell/virology , Cohort Studies , Combined Modality Therapy , DNA, Viral/genetics , Female , Follow-Up Studies , Health Status Disparities , Humans , Incidence , Male , Middle Aged , Neoplasm Staging , Oropharyngeal Neoplasms/therapy , Oropharyngeal Neoplasms/virology , Papillomavirus Infections/therapy , Papillomavirus Infections/virology , Prevalence , Prognosis , Prospective Studies , Retrospective Studies , Survival Rate , Treatment Outcome , White People/statistics & numerical data
SELECTION OF CITATIONS
SEARCH DETAIL
...