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1.
Indian J Pharmacol ; 55(6): 367-375, 2023.
Article in English | MEDLINE | ID: mdl-38174533

ABSTRACT

OBJECTIVE: Even though oxidative and inflammatory bursts are a big part of renal reperfusion injury (RI/R), Pistia stratiotes (PS) has been used for a long time to stop these overreactions. People have said that it can drop both blood sugar and cholesterol. Hence, the goal of this study was to show how PS changed kidney reperfusion damage in both diabetic and normal rats. MATERIALS AND METHODS: In the study, 30 min of renal ischemia (RI) was followed by 1 h of recovery for each rat. Before the test, PS (100 mg/kg p. o.) was given to the animals for 7 days. Then, using the mixture from the separated kidney tissues, the antioxidant, inflammation, and histopathological effects were determined. RESULTS: When compared to RI/R, diabetic rats given PS had lower blood sugar, aspartate aminotransferase, blood urea nitrogen, and creatinine, myeloperoxidase, C-reactive protein, and tumor necrosis factor-alpha levels in their urine. CONCLUSION: PS potentially worked in hyperglycemic rats protecting them against RI/R. It is possible that PS's ability to protect the kidneys of the test rats is due to its ability to fight free radicals, lower blood sugar, and stop inflammation.


Subject(s)
Araceae , Diabetes Mellitus, Experimental , Kidney Diseases , Reperfusion Injury , Humans , Rats , Animals , Diabetes Mellitus, Experimental/complications , Diabetes Mellitus, Experimental/drug therapy , Blood Glucose/metabolism , Kidney , Kidney Diseases/metabolism , Reperfusion Injury/drug therapy , Reperfusion Injury/prevention & control , Inflammation/metabolism , Inflammation/pathology , Oxidative Stress , Creatinine/metabolism , Creatinine/pharmacology
2.
J Vasc Access ; 18(5): 363-365, 2017 Sep 11.
Article in English | MEDLINE | ID: mdl-28777407

ABSTRACT

Not infrequently, interventionalists are faced with a patient with increased blood pressure who is about to undergo a dialysis access intervention such as tunneled hemodialysis catheter, percutaneous balloon angioplasty, or declotting procedure for a clotted arteriovenous access. This can frequently create a dilemma as functional dialysis access is needed to provide dialysis therapy and delaying treatment could result in a life-threatening situation, particularly in the presence of hyperkalemia. This article investigates hypertension in patients undergoing percutaneous dialysis access interventions and provides guidance to their management.


Subject(s)
Blood Pressure , Catheter Obstruction , Catheterization, Central Venous , Endovascular Procedures , Hypertension/therapy , Kidney Failure, Chronic/therapy , Renal Dialysis , Upper Extremity Deep Vein Thrombosis/therapy , Angioplasty, Balloon , Antihypertensive Agents/adverse effects , Blood Pressure/drug effects , Catheterization, Central Venous/adverse effects , Endovascular Procedures/adverse effects , Endovascular Procedures/instrumentation , Humans , Hypertension/complications , Hypertension/physiopathology , Kidney Failure, Chronic/diagnosis , Kidney Failure, Chronic/etiology , Kidney Failure, Chronic/physiopathology , Renal Dialysis/adverse effects , Stents , Thrombectomy , Treatment Outcome , Upper Extremity Deep Vein Thrombosis/diagnosis , Upper Extremity Deep Vein Thrombosis/etiology , Upper Extremity Deep Vein Thrombosis/physiopathology
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