ABSTRACT
In this study, we present a new cadmium(II)-based two-dimensional coordination polymer [Cd (L)(NA)(H2O)] (L = Iminol form of N-nicotinoyl glycinate, NA = nicotinate), 1, containing two linkers generated from N-nicotinoyl glycine. A comprehensive investigation was carried out during the synthesis of the coordination polymers by varying the reaction time interval and temperature, and it revealed the formation of three distinct phases, of which two phases were previously reported and one was a new compound (1). The structure of compound 1 was determined by single-crystal X-ray diffraction, and it shows a corrugated layer structure with hydrogen bond interactions leading to three-dimensional supramolecular arrangements. Compound 1 exhibited strong emission at 420 nm when excited at 260 nm in an aqueous medium. The emission behavior of this compound was used for the detection of various sulfonamide antibiotics, sulfadiazine, sulfamethazine, sulfachloropyridazine, sulfameter, sulfaquinoxaline, and sulfathiazole, in the presence of common water pollutants. The luminescence quenching response of compound 1 to sulfonamide antibiotics was significant, ranging from 81 to 94%, and the detection sensitivity reached parts per billion (ppb) levels (226-726 ppb). Compound 1 also used for the fabrication of Schottky diode devices with a barrier height of 0.86 eV along with an excellent ideality factor of 1.24.
ABSTRACT
BACKGROUND: Cancer is a life-threatening disease worldwide, but proper treatment has not yet been developed. Many therapies are available to treat cancer disorders, like chemotherapy, surgery, hormone therapy, and immunotherapy. Chemotherapy often relies on a combination of harmful, highly toxic platinum-based compounds. Also, there are chances of poor distribution of chemotherapeutic agents and cytotoxic to most cells which leads to damage to other healthy cells, also, there are chances of resistance. OBJECTIVE: The main objective of this study is the development of mesoporous silica nanoparticles. Mesoporous silica nanoparticles are recognized as carriers with high drug loading capacity and significant functionalized surface area for targeted drug delivery. Mesoporous silica nanoparticles have shape, particle size, pore volume, higher surface area, and the possibility of surface modification. Hence results in thermally and chemically stable nanomaterials. For targeted drug delivery, MSN is conjugated with a variety of ligands, including monoclonal antibodies, hyaluronic acid, transferrin, folic acid, etc., that have a particular affinity for the receptors that are overexpressed on the surface of malignant cells, so using this nanocarrier reducing the dose related toxicity of normal cell. METHODS: This review focuses on different methods for synthesizing mesoporous silica nanoparticles. Sol-gel method and modified stobber method were used for the synthesis of this nanoparticle. RESULTS: Successfully synthesized mesoporous silica nanoparticle with particle size around 50-200 nm and drug loading efficiency was found to be around 71%. CONCLUSION: Mesoporous silica nanoparticles are great carriers for intracellular and targeted drug delivery systems.
ABSTRACT
OBJECTIVE: This study aimed to evaluate the concordance of a new scoring system for neonatal abstinence syndrome (NAS) and NAS scores to the traditional Modified Finnegan Neonatal Abstinence Scoring Tool (M-FNAST) score. The NAS score is based on the physiology of withdrawal, with equal emphasis on behavior, and neurological signs. STUDY DESIGN: The NAS scores for a control group of 202 healthy, term neonates were compared with those for 45 term neonates with NAS. The NAS and M-FNAST scores obtained simultaneously in 45 term neonates with NAS were compared using correlation, linear regression, and receiver operating characteristic curve analysis to determine the validity, reliability, and specificity of the NAS scores. RESULTS: The association between the NAS and M-FNAST scores was high (Spearman's correlation, 83%; linear regression, 83%), with an area under the curve of the NAS score of 1.00 (p < 0.01). A cut-off NAS score ≥4 identified NAS neonates with a sensitivity of 100% and specificity of 96%. The values of intraclass correlation, interrater agreement, and Cronbach's α were 0.63, 0.88, and 0.63, respectively. CONCLUSION: The new NAS scoring system is valid, reliable, physiologically based, and correlates closely with the M-FNAST score. The NAS scores may require further validation before its use in clinical practice.
