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1.
J Am Vet Med Assoc ; 228(2): 210-5, 2006 Jan 15.
Article in English | MEDLINE | ID: mdl-16426187

ABSTRACT

OBJECTIVE: To evaluate completeness of excision and clinical outcome in dogs with cutaneous mast cell tumors (MCTs) excised with a lateral margin of 2 cm and a deep margin of 1 fascial plane. DESIGN: Prospective study. ANIMALS: 16 client-owned dogs with 1 or more cutaneous MCTs. PROCEDURE: Excision of MCTs was performed with a 2-cm lateral margin and a deep margin of 1 fascial plane. Histologic tumor grading was performed; surgical margins were categorized as complete or incomplete. Follow-up information was obtained via repeat examination of the dogs by veterinarians or client-completed questionnaires. RESULTS: 4 grade I and 19 grade II cutaneous MCTs were evaluated. Overall, 21 (91%) MCTs were completely excised; 2 grade II tumors had foci of mast cells at the 2-cm margin. Two dogs received adjunctive treatments following surgery. Follow-up information was available for all dogs (median follow-up period, 379 days; range, 51 to 538 days); no local recurrence was detected during this time. De novo MCTs were detected in 3 of 16 dogs at 37, 54, and 154 days after surgery. Via Kaplan-Meier analysis, median survival time and disease-free interval were both > 538 days (medians not yet reached). No prognostic variables were identified. CONCLUSIONS AND CLINICAL RELEVANCE: Excision with a 2-cm lateral margin and a deep margin of 1 fascial plane may result in satisfactory excision of grades I and II MCTs in dogs, with recurrence rates similar to those reported previously. Use of these margins may minimize complications associated with larger local tumor resection.


Subject(s)
Dog Diseases/surgery , Mast-Cell Sarcoma/veterinary , Neoplasm Staging/veterinary , Skin Neoplasms/veterinary , Animals , Disease-Free Survival , Dog Diseases/pathology , Dogs , Female , Male , Mast-Cell Sarcoma/pathology , Mast-Cell Sarcoma/surgery , Neoplasm Recurrence, Local/veterinary , Prospective Studies , Skin Neoplasms/pathology , Skin Neoplasms/surgery , Survival Analysis , Treatment Outcome
2.
Vet Radiol Ultrasound ; 45(1): 91-3, 2004.
Article in English | MEDLINE | ID: mdl-15005368

ABSTRACT

Five cats with melanoma involving the oral cavity were treated with hypofractionated radiation therapy (RT). Cobalt photons were used to administer three fractions of 8.0 Gray (Gy) for a total dose of 24 Gy. Four cats received radiation on days 0, 7, and 21 and one cat received radiation on days 0, 7, and 13. One of the cats received additional irradiation following the initial treatment course. Two cats received chemotherapy. Their age ranged from 11 to 15 years with a median age of 12 years. Three cats had a response to radiation, including one complete response and two partial responses. All five cats were euthanized due to progression of disease, with one cat having evidence of metastatic disease at the time of euthanasia. The median survival time for the five cats was 146 days (range 66-224 days) from the start of RT. The results of this study suggest that oral melanoma in cats may be responsive to hypofractionated RT, but response does not seem to be durable.


Subject(s)
Cat Diseases/radiotherapy , Dose Fractionation, Radiation , Melanoma/veterinary , Mouth Neoplasms/veterinary , Animals , Cat Diseases/mortality , Cat Diseases/pathology , Cats , Melanoma/radiotherapy , Mouth Neoplasms/radiotherapy , New York/epidemiology , Records/veterinary , Retrospective Studies , Survival Analysis , Treatment Outcome
3.
J Am Vet Med Assoc ; 224(2): 236-40, 2004 Jan 15.
Article in English | MEDLINE | ID: mdl-14736068

ABSTRACT

OBJECTIVE: To determine whether neoplastic mast cells extended into tissue 1, 2, or 3 cm laterally or deeper than 1 fascial plane from the visible edge of cutaneous mast cell tumors (MCTs) in dogs. DESIGN: Prospective study. ANIMALS: 21 client-owned dogs with > or = 1 cutaneous MCT PROCEDURES: After preparation for surgery, each dog's skin was marked 1, 2, and 3 cm from the tumor edge at 0 degrees, 90 degrees, 180 degrees, and 270 degrees. At each 3-cm mark, deep fascia was exposed and sutured to the skin; the tumor was excised in routine fashion and fixed in formalin. Tumors were graded; margins were examined histologically for neoplastic mast cells. RESULTS: 23 cutaneous MCTs in 21 dogs were included in this study. Fifteen (65%) tumors were located on the trunk, 5 (22%) on the hind limbs, and 3 (13%) on the head and neck. There were 3 (13%) grade-I and 20 (87%) grade-II tumors. All grade-I tumors were completely excised at all margins. Seventy-five percent of the grade-II tumors were completely excised at the 1-cm margin, and 100% were completely excised at the 2-cm margin. Two grade-II MCTs located on the hind limbs of dogs were excised with a complete but close (within 1 mm) deep margin. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that a 2-cm lateral margin and a deep margin of 1 fascial plane appear to be adequate for complete excision of grade-I and -II MCTs in dogs.


Subject(s)
Dog Diseases/surgery , Mast-Cell Sarcoma/veterinary , Skin Neoplasms/veterinary , Animals , Dog Diseases/pathology , Dogs , Female , Male , Mast-Cell Sarcoma/pathology , Mast-Cell Sarcoma/surgery , Neoplasm Recurrence, Local/pathology , Neoplasm Recurrence, Local/prevention & control , Neoplasm Recurrence, Local/veterinary , Neoplasm Staging/veterinary , Prospective Studies , Skin Neoplasms/pathology , Skin Neoplasms/surgery
4.
J Vet Diagn Invest ; 15(1): 77-81, 2003 Jan.
Article in English | MEDLINE | ID: mdl-12580303

ABSTRACT

A 7-year-old intact female red-eared slider (Trachemys scripta elegans) presented with anorexia of 2-3-weeks duration. Coelomic radiographs demonstrated 3 shelled eggs in the right cavity. Hormone therapy failed to induce oviposition. Exploratory laparotomy revealed 3 calcified eggs in the right oviduct and a large mass obliterating the left ovary. The large, multilobulate mass had scattered, firm, white nodules and weighed 450 g. Histopathology revealed a malignant teratoma composed of immature embryonaland extraembryonal elements derived from all 3 germ layers with multifocal epithelial anaplasia. This is the first report of a teratoma in chelonian gonadal tissue. Teratomas and reptilian gonadal neoplasia are reviewed.


Subject(s)
Ovarian Neoplasms/diagnosis , Ovarian Neoplasms/veterinary , Teratoma/diagnosis , Teratoma/veterinary , Turtles , Animals , Female , Ovarian Neoplasms/pathology , Ovarian Neoplasms/surgery , Ovary/pathology , Ovary/surgery , Teratoma/pathology , Teratoma/surgery
5.
J Am Anim Hosp Assoc ; 39(1): 86-9, 2003.
Article in English | MEDLINE | ID: mdl-12549620

ABSTRACT

The purposes of this study were to evaluate the efficacy of cobalt-60 radiotherapy in the treatment of nonkeratinizing squamous cell carcinoma of the nasal cavity in dogs and to compare this treatment group to historical controls. Six dogs with histopathologically confirmed nasal cavity nonkeratinizing squamous cell carcinoma were treated with cobalt-60 radiotherapy to a total dose of either 63 Gy or 54 Gy. Overall survival times ranged from 30 days to 330 days, with a median survival time of 165 days. Nasal cavity nonkeratinizing squamous cell carcinoma in the dog is an aggressive tumor that responds poorly to radiotherapy.


Subject(s)
Carcinoma, Squamous Cell/veterinary , Cobalt Radioisotopes/administration & dosage , Dog Diseases/radiotherapy , Nasal Cavity , Nose Neoplasms/veterinary , Animals , Carcinoma, Squamous Cell/radiotherapy , Dog Diseases/diagnostic imaging , Dog Diseases/mortality , Dogs , Louisiana , Nose Neoplasms/radiotherapy , Radiography , Radiotherapy Dosage/veterinary , Records/veterinary , Retrospective Studies , Survival Analysis , Treatment Outcome
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