ABSTRACT
We report here the first six cases of leprosy associated with HLA-identical allogeneic SCT in different phases and with different findings and outcomes. Skin and peripheral nerves may be sites of leprosy associated with SCT, stressing the importance of differential diagnosis between leprosy and GVHD or drug reactions. Clinical manifestations of leprosy before or after transplantation did not influence the outcome of SCT in our cases.
Subject(s)
Hematopoietic Stem Cell Transplantation/adverse effects , Leprosy/etiology , Adult , Diagnosis, Differential , Female , Humans , Leprosy/diagnosis , Leprosy/pathology , Male , Peripheral Nervous System Diseases/diagnosis , Peripheral Nervous System Diseases/etiology , Skin Diseases/diagnosis , Skin Diseases/etiology , Transplantation, Homologous , Treatment OutcomeABSTRACT
We report two cases of refractory chronic graft-versus-host disease after donor lymphocyte infusions in which the skin lesions improved dramatically with the use of intravenous pulses of lidocaine. This form of therapy has been used successfully for the cutaneous involvement of scleroderma and may have vasodilator and anti-inflammatory effects.
