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Bioorg Med Chem ; 32: 115973, 2021 02 15.
Article in English | MEDLINE | ID: mdl-33444846

ABSTRACT

Amongst heterocyclic compounds, quinoline is an advantaged scaffold that appears as a significant assembly motif for the development of new drug entities. Quinoline and its derivatives tested with diverse biological activity constitute an important class of compounds for new drug development. Therefore, many scientific communities have developed these compounds as intent structure and evaluated their biological activities. The present, review provides brief natural sources of quinoline and including a new extent of quinoline-based marketed drugs. This review also confers information about the biological activities of quinoline derivatives such as antibacterial, antifungal, antimycobacterial, antiviral, anti-protozoal, antimalarial, anticancer, cardiovascular, CNS effects, antioxidant, anticonvulsant, analgesic, anti-inflammatory, anthelmintic and miscellaneous activities.


Subject(s)
Analgesics/pharmacology , Anti-Infective Agents/pharmacology , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Antineoplastic Agents/pharmacology , Antioxidants/pharmacology , Antiprotozoal Agents/pharmacology , Analgesics/chemistry , Anti-Infective Agents/chemistry , Anti-Inflammatory Agents, Non-Steroidal/chemistry , Antineoplastic Agents/chemistry , Antioxidants/chemistry , Antiprotozoal Agents/chemistry , Humans , Molecular Structure , Quinolines/chemistry , Quinolines/pharmacology
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