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Coproduction of KPC-2 and IMP-10 in Carbapenem-Resistant Serratia marcescens Isolates from an Outbreak in a Brazilian Teaching Hospital.

Silva, Kesia Esther; Cayô, Rodrigo; Carvalhaes, Cecilia Godoy; Patussi Correia Sacchi, Flávia; Rodrigues-Costa, Fernanda; Ramos da Silva, Ana Carolina; Croda, Julio; Gales, Ana Cristina; Simionatto, Simone.

J Clin Microbiol ; 53(7): 2324-8, 2015 Jul.

Article in English | MEDLINE | ID: mdl-25878341

ABSTRACT

We describe an outbreak caused by KPC-2- and IMP-10-producing Serratia marcescens isolates in a Brazilian teaching hospital. Tigecycline was the only active antimicrobial agent tested. The blaIMP-10 gene was located in a new class 1 integron, named In990, carried by a nonconjugative plasmid, in contrast to blaKPC-2.

Subject(s)

Carbapenems/pharmacology , Disease Outbreaks , Serratia Infections/epidemiology , Serratia Infections/microbiology , Serratia marcescens/enzymology , beta-Lactam Resistance , beta-Lactamases/metabolism , Adult , Aged , Aged, 80 and over , Anti-Bacterial Agents/pharmacology , Brazil/epidemiology , Child, Preschool , Cross Infection/epidemiology , Cross Infection/microbiology , DNA, Bacterial/genetics , Female , Genes, Bacterial , Hospitals, Teaching , Humans , Infant , Integrons , Male , Microbial Sensitivity Tests , Middle Aged , Minocycline/analogs & derivatives , Minocycline/pharmacology , Molecular Sequence Data , Plasmids , Sequence Analysis, DNA , Serratia marcescens/drug effects , Serratia marcescens/isolation & purification , Tigecycline , beta-Lactamases/genetics

ABSTRACT

Subject(s)

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