ABSTRACT
O Carcinoma Odontogêncio de Células Claras (COCC), é uma neoplasia rara descrita pela primeira vez por Hansen em 1985. Inicialmente categorizado como benigno, foi reclassificado como maligno no ano de 2005 pela OMS, devido ao seu comportamento localmente agressivo, alta taxa de recidiva local e potencial, metástase a distância. O presente caso relata a abordagem terapêutica aplicada ao tratamento do COCC avançado de mandíbula em uma paciente de 23 anos, do sexo feminino. A tomografia evidenciava uma volumosa massa osteodestrutiva mandibular com cerca de 10,6 x 7,2 cm, que comprometia difusamente o arco central e ramos horizontais. Foi realizada mandibulectomia de arco central estendida aos ramos horizontais bilaterais e esvaziamento cervical supraomo-hioideo bilateral associado à reconstrução microcirúrgica com retalho de fíbula esquerda, seguida de radioterapia adjuvante na dose de 66Gy. Paciente completou seis meses de seguimento, sem evidência de doença e com excelente resultado estético e funcional, alimentando-se pela via oral e com boa fonação.
Clear cell odontogenic carcinoma (COCC) is a rare neoplasm first described by Hansen in 1985. Initially categorized as benign, it was reclassified as malignant in 2005 by the WHO, due to its locally aggressive behavior and high recurrence rate. local and potential, distant metastasis. The present case reports the therapeutic approach applied to the treatment of advanced COCC of the mandible in a 23-year-old female patient. The tomography showed a large mandibular osteodestructive mass measuring approximately 10.6 x 7.2 cm, which diffusely affected the central arch and horizontal branches. A central arch mandibulectomy extended to the bilateral horizontal branches and bilateral supra omohyoid neck dissection associated with microsurgical reconstruction with a left fibula flap were performed, followed by adjuvant radiotherapy at a dose of 66 Gy. The patient completed six months of follow-up, with no evidence of disease and excellent aesthetic and functional results, eating orally and with good speech
Subject(s)
Carcinoma , Mandibular Diseases , Neoplasms , Surgical Procedures, OperativeABSTRACT
Breast cancer appears as the main gynecological cancer and presents high morbidity and mortality. Because most diagnoses are made belatedly, it is necessary to seek therapeutic options that aim for advanced stages of the disease. This study aims to evaluate the antitumoral action of Stryphnodendron adstringens fruit extracts on 4T1 murine mammary carcinoma cell culture. The inhibitory potential of S. adstringens fruit extract on the metalloproteinases (MMPs) 2 and 9 was evaluated through zymography. From these results, MTT assays were performed to evaluate the extracts' effects on the murine mammary carcinoma 4T1 line cell viability. From the crude extract, the following extracts were obtained: hydroalcoholic (SAFCEA), hexane (SAFCEB), chloroform (SAFCEC), and ethyl acetate (SAFCED). Lastly, the migration of the cells treated with extracts SAFCEA and SAFCED was verified. The hydroalcoholic extract (SAFCEA) was the most efficient in inhibiting gelatinases. During the phytochemical study, it was noted that alkaloids were present in all partitions. The 50 % growth inhibition (IC50) concentrations found were: 40.1 µg/mL (SAFCEA) and 70.14 µg/mL (SAFCED). After the cellular cytotoxicity assay, cell morphology was altered by treatment with the selected partitions (SAFCEA and SAFCED), obtaining morphology consistent with apoptosis. The results demonstrate that S. adstringens extracts exhibit the inhibitory activity of MMP-2 and MMP-9 as well as cytotoxicity toward 4T1 tumor cells. These findings indicate that follow-up studies of the partitions from S. adstringens may lead to the development of novel chemotherapeutics for oncological treatments.
Subject(s)
Breast Neoplasms , Stryphnodendron barbatimam/therapeutic useABSTRACT
O lipossarcoma de laringe é uma neoplasia extremamente rara, acomete principalmente o sexo masculino, principalmente na quinta década de vida. Existindo apenas cerca de 40 casos descritos na literatura, desses nenhum em língua portuguesa. O presente caso relata o diagnóstico em um paciente do sexo masculino, 57 anos, ex-tabagista, apresentando alteração de voz e obstrução de via área. Foi optado por ressecção cirúrgica completa com achados sugestivos de lipossarcoma bem diferenciado. Foi optado por manter seguimento, não tendo sido indicado quimioterapia e radioterapia adjuvantes.(AU)
Laryngeal liposarcoma is an extremely rare neoplasm that affects especially men in the fifth decade of life. There are only about 40 cases described in the literature, none of them in the Portuguese language. We report the case of a 57-year-old, former smoker man presenting with voice disorders and airway obstruction. We opted for complete surgical resection with findings suggestive of well-differentiated liposarcoma. We chose to keep following the patient, and no adjuvant chemotherapy and radiotherapy were indicated. (AU)
