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Bioorg Med Chem Lett
; 28(5): 906-909, 2018 03 01.
Article
in English
| MEDLINE
| ID: mdl-29433930
ABSTRACT
The design and synthesis of macrocyclic inhibitors of human rhinovirus 3C protease is described. A macrocyclic linkage of the P1 and P3 residues, and the subsequent structure-based optimization of the macrocycle conformation and size led to the identification of a potent biochemical inhibitor 10 with sub-micromolar antiviral activity.