ABSTRACT
The synthesis of a new material based on Nd3+ ions doped into an imidazolium-type ionic liquid with further immobilization on a mesoporous silica support is reported. The material was investigated by DR-UV/VIS, FT-IR, thermogravimetric analysis, N2 adsorption measurements and time-resolved photoluminescence spectroscopy. The intensity of the near-infrared emission of Nd3+ was weak and the lifetime measured at about 910 nm was 7 micros.
ABSTRACT
In this clinic and prospective study we investigated the anesthetic and surgical particularities in laparoscopic cholecystectomy for 194 patients. Approximately the two third of patients have had a great mortality risk (ASA III and IV). 139 patients have had severe comorbid conditions. All patients were under general anesthesia with oro-tracheal intubation. The surgical time was between 27 and 148 minutes. The subjects of this study were old patients with acute cholecystitis and severe comorbid conditions. No significant incident or complication were noted, all patients have had a good outcome.
Subject(s)
Anesthesia, General , Cholecystectomy, Laparoscopic/methods , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Anesthesia, General/adverse effects , Female , Humans , Male , Middle Aged , Prospective Studies , Risk Factors , Time Factors , Treatment OutcomeABSTRACT
Studies were conducted using uni- and multilamellar liposomes to establish optimum conditions for influenza antigen incorporation in view of their transport to the target cells for experimental influenza prophylaxis in hybrid white mice. Radiometric determinations showed a good level of preparation purification, a good efficiency of incorporation in liposomes of the active biological material, the liposome linked radioactivity distribution among different organs. Charged liposomes induced solid and long lasting resistance against influenza control infection.
Subject(s)
Antigens, Viral/administration & dosage , Immunization/methods , Influenza Vaccines/administration & dosage , Orthomyxoviridae Infections/prevention & control , Animals , Antigens, Surface/administration & dosage , Antigens, Surface/isolation & purification , Antigens, Viral/isolation & purification , Drug Carriers , Drug Evaluation, Preclinical , Influenza Vaccines/isolation & purification , Liposomes , MiceABSTRACT
The experiment is aimed at establishing the consequences of the endotoxic stress (TAB) associated with alpha- or beta-adrenergic selective blocking drugs on the course of the acute irradiation disease in rats (700R, gamma rad Co60). TAB administered before or after irradiation, alone or associated with propranolol, increases the surviving rate at 30 and 60 days from exposure as compared to the controls (LD 95/30 days). Generally, dibenzyline has unfavourable effects on mortality and survival rate at the mentioned intervals. Based on the data obtained, an adrenergic component is analysed in achieving the survival increase by TAB and beta-adrenergic blocking substances; a hypothesis about the mechanisms involved is advanced.
Subject(s)
Adrenergic beta-Antagonists/pharmacology , Radiation Injuries, Experimental/drug therapy , Typhoid-Paratyphoid Vaccines/therapeutic use , Animals , Female , Male , Phenoxybenzamine/pharmacology , Propranolol/pharmacology , RatsABSTRACT
The amounts of cyclic AMP in brain, liver and intestinal mucosa have been measured in rats, at constant intervals, up to 18 days after whole-body exposure to either a unique moderate dose (500 rd) or a unique lethal dose (750 rd) of cobalt-60 gamma-radiation in association with a preliminary intraperitoneally treatment with prostaglandin E1 (5 microgram/100 g body weight/day) during five days. The amounts of tissular cyclic AMP in these two experimental groups were compared with those obtained from control groups identically irradiated or treated with prostaglandin E1. The effects of gamma-irradiation and prostaglandin E1 treatment on the cyclic AMP levels were found to be quite specific in these organs, suggesting that they contain different adenyl cyclase-cyclic AMP-phosphodiesterase systems: a cerebral system which is influenced by both gamma-radiation and prostaglandin E1, a hepatic system which is "radioresistant" and an intestinal system which is not influenced by prostaglandin E1. When associated with gamma-radiation, this prostaglandin is capable, on the one hand, to annul the "radioresistance" of the hepatic cyclic AMP system and, on the other hand, to annul the "radiosensitivity" of the intestinal cyclic AMP system.
Subject(s)
Cyclic AMP/metabolism , Prostaglandins E/pharmacology , Radioisotope Teletherapy , Animals , Brain/metabolism , Brain/radiation effects , Cobalt Radioisotopes , Female , Intestinal Mucosa/metabolism , Intestinal Mucosa/radiation effects , Liver/metabolism , Liver/radiation effects , Male , RatsABSTRACT
The total amounts of cyclic AMP in liver, brain and intestinal mucosa have been measured in rats, at constant intervals, up to 18 days after whole body exposure to either a unique moderate dose (500 rd) or a unique lethal dose (750 rd) of cobalt-60 gamma-radiation. This radiation, even in a lethal dose, was found to induce no significant changes in the hepatic levels of cAMP. In contrast, an abrupt short-lasting increase in the levels of cAMP was observed in brain and intestinal mucosa after a 500-rd-irradiation, and a progressive long-lasting increase in its levels in the intestinal mucosa and, especially, in the brain was found after a 750-rd-irradiation. It is concluded that these organs contain different cAMP systems, which would explain, at least in part, their dissimilar responses to the ionizing rays.
Subject(s)
Brain/radiation effects , Cyclic AMP/metabolism , Intestinal Mucosa/radiation effects , Liver/radiation effects , Radiation Effects , Adenosine Triphosphate/metabolism , Animals , Female , Gamma Rays , Male , Mitochondria/radiation effects , Mitochondria, Liver/radiation effects , NAD/metabolism , NADP/metabolism , Radiation Dosage , RatsABSTRACT
Experiments in rats exposed to a moderate dose of 60Co gamma-radiation and treated with either cystamine, AET, complamin or alpha-methyldopa suggested that the efficiency of a radioprotective drug might be related to its ability to maintain low levels of ATP-ase activity in blood and tissues after irradiation.
Subject(s)
Adenosine Triphosphatases/metabolism , Cystamine/pharmacology , L-Lactate Dehydrogenase/metabolism , Methyldopa/pharmacology , Radiation Effects , Theophylline/analogs & derivatives , Xanthinol Niacinate/pharmacology , beta-Aminoethyl Isothiourea/pharmacology , Animals , Cobalt Radioisotopes , Gamma Rays , Intestinal Mucosa/enzymology , Liver/enzymology , Rats , Spleen/enzymologyABSTRACT
The changes in the amounts of blood and tissular sulfhydryl groups and lipid peroxides were investigated in lethally gamma-irradiated rats treated with cystamine, AET (radioprotectors) or alpha-methyl-dopa (a radiosensitizer). The results of experiments revealed the following findings: 1. The ionizing radiation generally causes increases in the levels of tissular sulfhydryl groups and lipid peroxides (excepting the hepatic levels of these compounds). 2. AET and, especially, cystamine are able to reverse the radiation-induced changes in the tissular amounts of sulfhydryl groups and lipid peroxides; there are close relationships between this effect (including its intensity and extension) and the radioprotective action of these drugs. 3. In spite of its radiosensitizing action, alpha-methyl-dopa induces approximately similar changes in the tissular amounts of sulfhydryl groups and lipid peroxides, suggesting that biochemical processes other than an excessive yield of free radicals are also involved in radiosensitivity.
