ABSTRACT
En este artículo se presenta una idea original: inhibir la contracción miocárdica en forma regional y selectiva sin inducir necrosis. Se propone como una posible opción terapéutica en miocardiopatía hipertrófica asimétrica obstructiva, y se plantean 2 modelos farmacológicos basados en la administración intramiocárdica de toxina botulínica y de wortmanina.
The purpose of this paper is to introduce a new idea: local inhibition of contractility without necrosis. It's potential usefulness in hypertrophic cardiomyopathy treatment is discussed and 2 pharmacological models, administrating botulinum toxin and wortmannin directly in the myocardium are disclosed.
Subject(s)
Androstadienes/administration & dosage , Botulinum Toxins/administration & dosage , Cardiomyopathy, Hypertrophic/drug therapy , Models, Theoretical , Androstadienes/pharmacology , Botulinum Toxins/pharmacology , Injections, Intralesional , Myocardial Contraction/drug effects , Necrosis/prevention & controlABSTRACT
The purpose of this paper is to introduce a new idea: local inhibition of contractility without necrosis. It's potential usefulness in hypertrophic cardiomyopathy treatment is discussed and 2 pharmacological models, administrating botulinum toxin and wortmannin directly in the myocardium are disclosed.
Subject(s)
Androstadienes/administration & dosage , Botulinum Toxins/administration & dosage , Cardiomyopathy, Hypertrophic/drug therapy , Models, Theoretical , Androstadienes/pharmacology , Botulinum Toxins/pharmacology , Injections, Intralesional , Myocardial Contraction/drug effects , Necrosis/prevention & control , WortmanninABSTRACT
It has been proposed that natural autoreactivity plays a physiological role in the immune system by connecting all these clones (Id/anti-Id) and forming a dense and highly regulated network. In the present work, we analyzed the connectivity pattern in Chagas disease. Serum samples of 20 chronic chagasic cardiopathy (CCC) patients with dilated cardiopathy, 20 infected-asymptomatic subjects (IAS), and 20 healthy seronegative controls (H) were tested. Pattern of connectivity was distinguishable from that of healthy donor and those with CCC and IAS. This suggests that there are alterations in regulatory networks, inclusive being more evident in CCC patients than in IAS.