Total cysto-pericystectomy for huge echinococcal cyst located on hepatic segment IVb. Case report and review of the literature.

Hepatic hydatid disease is located mainly in the right liver. It is usually solitary and asymptomatic; however, a large cyst may cause compression symptoms. We report a case of a huge echinococcal cyst located in segment IVb of the liver in a 39-year-old female, 17 x 11 cm in dimensions, causing persistent epigastric pain and discomfort. The diagnosis was made by a computed tomography (CT) scan, which showed the cystic mass with the characteristic daughter cysts and reactive caps (pericystic wall) consisting of fibrous connective tissue and calcifications. The patient underwent radical resection by total cysto-pericystectomy and had an uneventful postoperative course. Follow-up showed no recurrence in CT and normal liver function test. Total cysto-pericystectomy, as an alternative to hepatectomy, is the preferable choice of radical resection operation, nowadays, in the management of liver hydatid disease even in huge cysts.

Complicated liver echinococcosis: 30 years of experience from an endemic area.

BACKGROUND AND AIMS: Although declining, cystic echinococcosis is still a serious public health issue in Greece. This study evaluated the clinical features, management, and short-term outcome of patients with complicated liver echinococcosis. MATERIAL AND METHODS: A total of 227 patients who were operated on for 322 echinococcal cysts of the liver were retrospectively evaluated. Patients were divided into those with complicated disease (53.7%) and those with noncomplicated disease (46.3%). Intrabiliary rupture (34.4%), cyst infection (32.7%), and their combination (24.5%) were the most common complications. Demographic characteristics, previous hydatid cyst surgery, cyst multiplicity and location, presenting symptoms and signs, types of complicated disease, operative procedures performed, postoperative complications, and hospital stay were assessed. RESULTS: Patient demographics and cyst characteristics demonstrated no significant difference between the two groups. The complicated disease group had significantly more pronounced clinical presentations and higher postoperative morbidity. Choice of surgical procedure depended upon cyst location and surgeon preference. Both conservative and radical procedures were performed, supplemented with additional management of the biliary tree when indicated. CONCLUSIONS: Complicated liver echinococcosis demonstrates several distinct features that differentiate it from the noncomplicated disease. Frequently severe clinical manifestations, complexity of surgical management, and the increased postoperative complications characterize complicated liver echinococcal disease.

Intramedullary nailing of trochanteric fractures: central or caudal positioning of the load carrier? A biomechanical comparative study on cadaver bones.

BACKGROUND: Current recommendations with regard to central or caudal positioning of the femur head carrier in the management of trochanteric fractures are contradictory. METHODS: A standardised pertrochanteric osteotomy was stabilised in 15 pairs of cadaver femurs by means of intramedullary osteosynthesis (5xPFN-A-Synthes, 5xIntertan-Smith&Nephew, 5xTargon-PF-Aesculap). For each pair randomised central (group A) or caudal (group B) implantation of the femoral neck component was performed. Subsequently, the constructs were axially loaded to 2100N. In the absence of cut out after 20,000 cycles, load was increased to a maximum force of 3100N. Angular displacement was recorded based on ultrasound. Migration of the load carrier in the femoral head was monitored radiologically. FINDINGS DISPLACEMENT: No significant difference between groups (p>0.15) was found for the first 50 load cycles. A significantly greater degree of varus deformity was observed in group A (p=0.049) after 2000 load cycles and became more apparent as the number of load cycles increased (after 6000 cycles p=0.039, after 20,000 cycles p=0.034, after 22,000 cycles p=0.016). Angular displacement in the other two planes did not differ significantly across groups. CUT OUT: Migration of the load carrier in the femoral head was not significantly different for the two groups. Overall cut out occurred in 9 constructs, 3 in group A and 6 in group B. The difference in cut-out rate was not significant (p=0.213, chi-squared test). CONCLUSION: Biomechanical superiority can be shown for caudal positioning of the femoral neck load carrier in terms of reduced varus deformity. The incidence of cut out is however unaffected by the position of the load carrier.

Postoperative adhesion prevention using a statin-containing cellulose film in an experimental model.

BACKGROUND: Intraperitoneal adhesions are a common problem in abdominal surgery. The aim of this study was to compare the effectiveness of Statofilm, a novel antiadhesive film based on cross-linked carboxymethylcellulose and atorvastatin, with that of sodium hyaluronate-carboxymethylcellulose (Seprafilm(®)) in the prevention of postoperative intraperitoneal adhesions in rats. METHODS: One hundred male Wistar rats underwent a laparotomy and adhesions were induced by caecal abrasion. The animals were allocated to five groups: a control group with no adhesion barrier, Seprafilm(®) group, placebo group with a film containing carboxymethylcellulose without atorvastatin, and low- and high-dose groups with films containing carboxymethylcellulose and atorvastatin 0·125 and 1 mg per kg bodyweight respectively. Adhesions were classified by two independent surgeons 2 weeks after surgery. Caecal biopsies were obtained for histological evaluation of fibrosis, inflammation and vascular proliferation. RESULTS: All antiadhesive film groups (Seprafilm(®), placebo, low-dose and high-dose) had statistically significant adhesion reduction compared with the control group (P < 0·001, P = 0·015, P < 0·001 and P < 0·001 respectively). The low-dose Statofilm was superior to Seprafilm(®) in terms of adhesion prevention (P = 0·001). Adhesions were present in three-quarters of rats in the Seprafilm(®) group, but only one-quarter in the low-dose Statofilm group. CONCLUSION: The data suggest that the newly developed adhesion barrier Statofilm has better results than Seprafilm(®) in preventing postoperative adhesions in rats. A low-dose atorvastatin-containing film, such as Statofilm, could be evaluated for future clinical application.

Intraperitoneal administration of bevacizumab intraoperatively does not affect abdominal wound healing in rats.

BACKGROUND: Bevacizumab is a monoclonal antibody targeted at vascular endothelial growth factor (VEGF) to treat advanced colorectal cancer as well as other malignancies, but the ideal time point for its administration in patients scheduled for surgery is not well defined due to serious concerns regarding possible side effects on wound healing. Therefore, we conducted an experimental study in rats to clarify this issue. METHODS: Four groups of 10 Wistar rats each underwent a 4-cm midline laparotomy and closure of the wound in 2 layers. In the treatment groups (A and B), bevacizumab (Avastin(®)) received a single dose of 5 mg/kg i.p., and an equal amount of saline was given to the control groups (C and D). Groups A and C were sacrificed on the 7th postoperative day, and groups B and D on the 14th postoperative day. Wounds were inspected by two independent observers upon sacrifice and results were recorded; wound tissues were sent for histology to assess the degree of fibrosis and measurement of tissue hydroxyproline levels. Serum levels of endothelin-1, C-reactive protein, pro-oxidant/antioxidant balance and carbonylated proteins were also determined. For statistical analysis, the Mann-Whitney U test was used. RESULTS: Wound healing did not differ among groups both on the 7th and the 14th postoperative days, and there was also no significant difference regarding the degree of inflammation, fibroblast proliferation and collagen synthesis, as well as hydroxyproline and biochemical marker levels among the groups. CONCLUSIONS: Intraperitoneal bevacizumab administered intraoperatively does not significantly affect abdominal wound healing in rats.

[Operative treatment of rhizarthritis: comparison of ligament reconstruction according to Epping with trapezectomy and interposition of pyrocarbon spacers as replacement of the trapezium]. / Operative Versorgung der Rhizarthrose: Vergleich der Resektionssuspensionsarthroplastik mit der Trapezektomie und Interposition eines Pyrocarbonspacers als Trapeziumersatz.

BACKGROUND: Rhizarthritis is the most common form of arthritis of the hand with a frequency of 10% and conservative as well as surgical methods of treatment are available. The aim of this study was to compare the results of resection suspension arthroplasty according to Epping with trapezium replacement using pyrocarbon spacers. MATERIAL AND METHODS: Between January 2001 and December 2008 a total of 84 patients were surgically treated for rhizarthritis in our clinic. Of these patients 12 were treated with other surgical procedures, 40 with resection suspension arthroplasty according to Epping and 32 with pyrocarbon spacers as trapezium replacement. The patients were examined in a retrospective study and success of treatment was evaluated according to the Buck-Gramcko criteria. RESULTS: According to the evaluation criteria over 80% of patients in both collectives achieved very good or good operative results with the same degree of satisfaction. CONCLUSION: The results of this study confirm the value of resection suspension arthroplasty according to Epping for surgical treatment of rhizarthritis. Using trapezectomy with interposition of pyrocarbon spacers good or very good results can be achieved in the majority of cases. Essential points of criticism are the current material cost of 930 Euros and 4 dislocations in our collective but with good multiaxial movement and loading capacity. Comparable results using alternative procedures indicate that the results of further studies and long-term results will be decisive for establishment of this operational procedure.

[Operative treatment of the mallet fracture using a hook plate]. / Die Versorgung der Fraktur der dorsalen Endphalanxbasis mit der Hakenplatte.

AIM: The aim of the present investigation was to evaluate the outcome after operative treatment of dorsal distal phalanx fractures near to the base of type Doyle IVb and IVc by means of a hook plate. PATIENTS AND METHODS: Between February 2002 and September 2009 77 patients were treated by operation by means of 77 hook plates because of a fracture of the dorsal distal phalanx near to the base of type Doyle IVb and IVc. 59 of these patients, 13 women, 46 men, with an average age of 29.3 (13-72) years were followed up for on average 38.3 (3-69) months after operation. At follow-up the range of movement in the distal interphalangeal joint was measured compared to the other hand, nail growth defects were registered and an X-ray examination of the finger was performed. The patients were asked about pain, limitations of function, the satisfaction with the aesthetic result and whether the patients would undergo the same operation once more. The total result was judged by means of a self-made scale of assessment by evaluating the objective and subjective data. RESULTS: Postoperative bleeding, disorders of wound healing and infections were not observed. In 7 patients nail growth defects were found, 3 of which were subjectively very irritating. The material for osteosynthesis was removed 14 times, while the plate had to be removed prematurely due to imminent perforations two times. After a renewed trauma, a dislocation of the fragments was observed. The mean range of movement in the distal interphalangeal joint was amounted to 77 (0-90) degrees, showing a mean deficiency in extension of 7 degrees (0-32 degrees) and a mean deficiency in flexion of 7 degrees (0-40 degrees) compared to the unharmed opposite side. The total result was assessed 51 times (84.7%) as very good, 5 times (8.5%) as good and 4 times (6.8%) as bad. CONCLUSION: Even if the operation technique is relatively uncomplicated and even in the majority of the cases one can achieve very good or good results in the treatment of the dorsal distal phalanx fractures near to the base, the rate of complication is significant with 7 nail growth defects and two premature removals of the plate due to imminent perforation of the skin. Considering this rate of complication the indication, the operation technique and the implant require verification.

Tension-free by mesh-plug technique for inguinal hernia repair in elderly patients.

BACKGROUND: elderly patients are steadily becoming a growing part of the population. The aim of this study is to evaluate the outcome of open inguinal hernia repair in patients aged over 65 years. METHODS: from January 1999 to December 2008, a total of 719 patients underwent open tension-free inguinal hernia repair with mesh-plug; 301 among them were ≥ 65 years old. RESULTS: elderly patients had a mean age of 72.4 years (women 3.3%), while the mean age of younger patients was 48.7 years (women 5.7%). According to the ASA score, patients aged ≥ 65 years were at significantly higher risk than the younger patients. Spinal anesthesia was used most frequently in both groups. No significant differences were found in postoperative pain, mortality and recurrence. Morbidity and hospital stay were significantly higher in patients aged ≥ 65 years. CONCLUSIONS: open hernia repair in the elderly is safe and well tolerated, but it is associated with higher morbidity and longer hospitalization.

Current management of diverticular disease of the colon.

The medical treatment plays the first role in the vast majority of cases. Severe acute diverticulitis requires hospitalization and supporting care with intravenous fluids and antibiotics such as ciprofloxacin and metronidazole. Emergency operative intervention is necessary if complication occurs. Laparoscopic surgery has a well-defined place and such colectomy has been gaining, nowadays, more popularity.

Retractile mesenteritis appearing as a sigmoid colon tumor.

Retractile mesenteritis is a rare, fibrosing, inflammatory disease affecting the adipose tissue of the intestinal and colonic mesentery. So far, about 300 cases have been reported in the literature. We present a case of retractile mesenteritis.

Role of real-time RT-PCR platform technology in the diagnosis and management of notifiable avian influenza outbreaks: experiences in Great Britain.

Diagnosis and management of avian influenza outbreaks now include the use of validated real-time reverse transcription PCR (RRT-PCR) methods in many countries, including all member states of the European Union. Two outbreaks in poultry of notifiable avian influenza (H5 and H7 subtypes) that occurred in Great Britain during 2007 will serve as examples in which RRT-PCR demonstrated its value in 1) rapid diagnosis and confirmation of disease by sensitive and specific laboratory testing of samples derived from the index cases and 2) high-volume, rapid testing of surveillance samples. The two poultry outbreaks followed the incursion of a H7N2 low-pathogenicity notifiable avian influenza (LPNAI) virus (May-June 2007) and a Eurasian lineage H5N1 highly pathogenic notifiable avian influenza (HPNAI) virus (November 2007). Coupled with the use of high-throughput, robotic RNA extraction methods, a total of approximately 9300 and 20,300 field samples were tested by appropriate, validated RRT-PCR assays during the 4- and 5-wk duration of the H7N2 LPNAI and H5N1 HPNAI outbreaks, respectively. Fundamental features of the validated RRT-PCR assays used included their high degree of sensitivity, specificity, and rapidity, attributes that were invaluable in providing timely and accurate information for notifiable AI outbreak management.

Deeply infiltrating rectal endometriosis with lymph node involvement.

BACKGROUND: Sigmoidorectal endometriosis accounts for 70% of the cases of intestinal endometriosis. Symptoms are non-specific, frequently resembling adenocarcinomas. CASE: A 45-year-old woman complaining of recurrent rectal bleeding underwent colonoscopy in which a rectal polypoid mass was found. She underwent anterior rectosigmoidectomy and the histological examination of the resected bowel revealed rectal endometriosis with lymph node involvement. CONCLUSION: Lymphatic infiltration of epicolic lymph nodes raises questions about the benign nature of this presumed innocent disease.

Children and adolescents with posttraumatic shoulder instability benefit from arthroscopic stabilization.

INTRODUCTION: Traumatic dislocation of the shoulder in childhood is rare, accounting for only 0.01% of all injuries in this age class. However, literature does contain indications that post-traumatic instabilities and re-dislocations occur with more than average frequency in children and adolescents. MATERIAL AND METHODS: This study describes the technique and results of arthroscopic stabilization of the shoulder joint before the completion of growth. Over a period of four years, seven patients were treated prior to reaching skeletal maturity. Five patients were treated by means of arthroscopically assisted labral refixation using suture anchor systems. RESULTS: Arthroscopic labral refixation for post-traumatic shoulder instability could be carried out using the same surgical procedure as in adults. Clinical follow-up was undertaken after 12 to 48 (average 26) months using modified Constant-Murley and Rowe scores. Instability, re-dislocations and postoperative impairment of mobility did not occur after arthroscopic treatment, with an average Constant score of 92 points (Rowe score >95 points). CONCLUSION: This study demonstrated that this technique can be used successfully in children and young people prior to skeletal maturity. Considerable experience in adult shoulder reconstruction promises excellent results in children and adolescents, too. There was no evidence of growth disturbance or biodegradation-associated problems in this group of children and adolescents. Delay of labral refixation until adulthood is therefore not indicated.

Acute afferent loop syndrome: a true emergency. A case report.

Afferent loop syndrome is a relatively rare complication after subtotal gastrectomy. We present a late onset of afferent loop obstruction, in a patient who underwent Billroth II gastrectomy with Roux-Y reconstruction for a gastric ulcer 27 years ago. A 60-year-old male was admitted to the hospital with an 8-hour history of acute epigastric pain, associated with vomiting, fever and signs of sepsis. Laboratory tests revealed leukocytosis, elevated liver function tests and high serum amylase. An obstructed afferent loop appeared on CT as a fluid filled tubular mass, crossing the middle line between the aorta and the mesenteric vessels. Advanced sepsis was also seen in the peripancreatic and retroperitoneal region. Although the patient was operated on immediately after diagnosis with reconstruction of Roux-Y anastomosis, he died 12 hours later. Afferent loop syndrome is quite uncommon, and must be suspected in patients who have undergone subtotal gastrectomy. Clinical manifestations of the syndrome are usually non-specific. CT is the examination of choice and surgery the first choice treatment.

Early propranolol administration does not prevent development of esophageal varices in cirrhotic rats.

BACKGROUND AND AIMS: Variceal bleeding is the most serious complication of portal hypertension associated with high mortality. This study was conducted to investigate any protective effect of early propranolol administration in the development and degree of esophageal varices in cirrhotic rats with portal hypertension. This topic is controversial in the literature. METHODS: For the development of liver cirrhosis and esophageal varices, 60 rats underwent ligation of the left adrenal vein and complete devascularization of the left renal vein, followed by phenobarbital and carbon tetrachloride (CCl(4)) administration. This operation enhances the development of cephalad collaterals, responsible for the induction of esophageal varices. After 2 weeks of CCl(4) administration, the rats were randomly separated into 2 groups. In group I, propranolol was continuously administered intragastrically throughout the study, whereas in group II normal saline (placebo) was administered instead. Cirrhosis was detected clinically by ascites development. Hemodynamic studies and morphometric analysis of the lower esophagus were performed after complete induction of cirrhosis, measuring the following parameters: portal pressure, total number of submucosal veins, total submucosal vessel area, mean cross-sectional submucosal vessel area, relative submucosal area (percentage) occupied by vessels and area of the single most dilated submucosal vein. RESULTS: The statistical analysis revealed no statistically important difference between the 2 groups for the morphometrically studied parameters. However, portal venous pressure was lower in group I. CONCLUSION: Early propranolol administration did not protect rats from developing esophageal varices, despite the fact that a significant decrease in portal pressure was detected.

Primary Ewing sarcoma of the stomach--a newly described entity.

The Ewing sarcoma family of tumors (ESFT) includes classic Ewing sarcoma of the bone, extraosseous or soft tissue Ewing sarcoma, Askin tumors of the chest wall, and peripheral primitive neuroectodermal tumors of the bone and soft tissues. They share a common neural histogenesis, tumor genetics and biology. The genetic hallmark of the ESFT is the presence of t(11;22)(q24;q12), which creates the EWS/FLI1 fusion gene and results in the expression of a chimeric protein. Although Ewing tumors can occur at any age, the great majority are found in individuals less than 20 years of age. We herein report a case of gastric Ewing sarcoma in a 68-year-old male. This patient illustrates the second reported occurrence of primary Ewing sarcoma in the stomach and the first reported with the t(11;22)(q24;q12) gene translocation.

Pelvic malakoplakia simulating recurrence of rectal adenocarcinoma: report of a case.

Malakoplakia represents a chronic inflammatory disease associated with a broad spectrum of bacterial infections. On histopathology, Michaelis-Gutmann bodies are considered as pathognomonic histopathological findings. Rarity of the disease and wide variety of clinical presentation makes its diagnosis very challenging. We report herein the case of a 66-year-old woman who, having undergone lower anterior resection for rectal adenocarcinoma 3 and a half years ago, presented with urinary frequency and dull abdominal pain. CT scan revealed a soft tissue tumour infiltrating the preperitoneal fat over the urinary bladder, which was considered as recurrence of the rectal carcinoma. On laparotomy, a tumour invading the bladder, small intestine and the anterior abdominal wall was resected and the patient recovered uneventfully. On histopathology, malakoplakia of urinary bladder was revealed. Overstaging of patients' malignancy due to malakoplakia is not uncommon, so its early identification can help avoid incorrect treatment.

[Subjective and clinical outcome after rotator cuff repair in elderly patients]. / Subjektives und klinisches Outcome nach Rekonstruktion der Rotatorenmanschette im höheren Lebensalter.

AIM: The indication for rotator cuff repair in elderly patients is controversial. Results after refixation of the cuff in dependence on age, size of rupture and retraction using the Constant-Murley and DASH scores were analysed. We wanted to examine whether the results of rotator cuff repair allow us to define the indication for the operative procedure. METHODS: Over a period of six years 154 patients with symptomatic rotator cuff lesion had undergone repair of cuff tears, and 119 patients were evaluated for follow-up applying the Constant-Murley and DASH scores for self-assessment. RESULTS: On average a postoperative Constant-Murley score of 83.5 points was obtained. A significant difference between the operated and the opposite shoulder was observed. In the DASH score a mean point value of 23.6 was calculated. In all combined groups more than 50% of the patients and 27% of the patients in the Bateman IV group were satisfied with the postoperative results using both scores. Reruptures were seen mostly in the Bateman IV group. CONCLUSION: The difference of score points between the operated to the opposite site in Bateman II and III groups did not show unfavourable values at higher age whereas adverse data were found in the Bateman IV group. In the Bateman IV group, in addition to cuff repair a muscle flap or arthroplasty should be considered in the choice of operative procedure.

Does emergency surgery affect resectability of colorectal cancer?

OBJECTIVE: Emergency surgery for colorectal cancer is common in daily practice, and is mainly implied by bowel obstruction. It is related to increased morbidity and mortality. Its relation with the stage and respectability of the disease is uncertain. This study aims to further clarify these parameters. PATIENTS AND METHODS: Over the past 24-year period 121 patients had an emergency operation (12%) from a total of 1009 patients with colorectal carcinoma. There were 59 men (48.8%) and 62 women (51.2%) with a mean age of 68 years (range 21-93); 61 patients (50.4%) were > or = 70-years-old. The data of all these patients were studied retrospectively in comparison with those who underwent elective surgery. Emergency cases were further divided into two age groups (> or = 70 and < 70 years) and compared. The tumour location was mainly in the left colon, whereas obstruction was the predominant reason for acute presentation. RESULTS: On operation, absence of macroscopic spread was noted in 57.8% of emergency cases and 72% of elective cases (p < 0.05). The resectability rates were 75% and 90% respectively (p < 0.05), and were not significantly affected by the age factor. There were no differences in the grade of malignant cell differentiation or in the depth of microscopic invasion (p > 0.05) in either group. For emergency operations, the morbidity was 20% (24 patients) and the 30-day mortality rate was 5.8% (7 patients). Both parameters were higher in patients > or = 70-years-old. CONCLUSION: Emergency surgery for colorectal carcinoma is related to lower resectability and to higher--but acceptable--postoperative morbidity and mortality rates, when compared with elective surgical management.