ABSTRACT
With the use of nuclear magnetic resonance we investigated the effect of consumption of water with the modified isotope content on the composition of deuterium in the blood, assessed the state of pro-oxidant-antioxidant system in the blood and lyophilized tissues (liver, kidneys) under prolonged oxidative stress. Possible mechanisms of direct and indirect antioxidant effects of the water with modified isotope content and the perspectives of its use for nutritional correction of abnormalities of oxidative metabolism during special physiological conditions and in clinical practice are discussed.
Subject(s)
Antioxidants/metabolism , Deuterium , Free Radicals/metabolism , Mineral Waters , Oxidative Stress , Soft Tissue Infections/blood , Animals , Deuterium/analysis , Deuterium/blood , Deuterium/pharmacology , Kidney/metabolism , Liver/metabolism , Magnetic Resonance Spectroscopy , Male , Mineral Waters/administration & dosage , Mineral Waters/analysis , RatsABSTRACT
Polypeptide C (molecular weight 2640 Dalton) extracted from artificial gastric juice), copepsidyl (containing high dosage of pepsin) and panintestine (polyenzyme drug) are studied for their effect on the activity of digestive enzymes of glandular gastric element pancreas and small intestine of rats. It is established that all mentioned drugs stimulate enzymogenesis in the analyzed organs. The activity of pepsin increases in homogenates of gastric mucosa, the activity of trypsin, total proteinases, carboxypeptidase and amylase grows in pancreas homogenates, and that of leucineaminopeptidase--in small intestine.
