[First experience of applying domestic video fluorescent equipment for visualization and blood flow evaluation of the parathyroid glands]. / Pervyi opyt primeneniya otechestvennoi videoflyuorestsentnoi ustanovki dlya vizualizatsii i otsenki krovotoka okoloshchitovidnykh zhelez.

In recent years, predictive methods for assessing the preservation of the parathyroid glands have been actively implemented. The article describes the first experience of evaluating the blood supply of the parathyroid glands by quantitative determination of the indocyanine green (ICG) accumulation index in real time in 6 patients before and after a thyroidectomy with central neck lymph node dissection for papillary thyroid cancer. Intraoperative fluorescent angiography was performed by using domestic equipment with a fluorescent module, as well as by using a domestic medication of ICG. Intraoperative values of the ICG accumulation index were compared with the levels of ionized calcium and parathyroid hormone perioperatively. No clinical manifestations of hypocalcemia were detected in the postoperative period. The obtained results showed the informativeness of the numerical assessment of the intensity of ICG fluorescence. The evaluation of the distribution (accumulation) of ICG has prospects for practical application in thyroid surgery in the formation of tactics for preserving the parathyroid glands and predicting postoperative hypoparathyreosis.

[A comparative hormonal and clinical analysis of thyrotoxicosis with- or without comorbid resistant depression].

AIM: To compare clinical and hormonal status in thyrotoxicosis with- or without comorbid resistant depression. MATERIAL AND METHODS: We examined 100 patients with thyrotoxicosis, including 61 patients with comorbid resistant depression (RD) and 39 patients without RD. Mental status, somatic symptoms of disease and blood content of main thyroid hormones were studied. The Hamilton scale was used to measure depression and anxiety. RESULTS AND CONCLUSION: Depression developed in the structure of thyrotoxicosis increased the symptoms of hyperthyroidism. However, it did not change the general tendency of development of the main disease assessed by hormonal indicators.

Singlet-triplet fission of carotenoid excitation in light-harvesting LH2 complexes of purple phototrophic bacteria.

The current generally accepted structure of light-harvesting LH2 complexes from purple phototrophic bacteria conflicts with the observation of singlet-triplet carotenoid excitation fission in these complexes. In LH2 complexes from the purple bacterium Allochromatium minutissimum, a drop in the efficiency of carotenoid triplet generation is demonstrated, which correlates with the extent of selective photooxidation of bacteriochlorophylls absorbing at ~850 nm. We conclude that singlet-triplet fission of carotenoid excitation proceeds with participation of these excitonically coupled bacteriochlorophylls. In the framework of the proposed mechanism, the contradiction between LH2 structure and photophysical properties of carotenoids is eliminated. The possibility of singlet-triplet excitation fission involving a third mediator molecule was not considered earlier.

[Potential of endoscopic hemostasis in patients with gastroduodenal bleedings].

The authors have analyzed their experiences with treatment of 61 patients using the method of endoscopic clipping: 24 of them had the source of bleeding in chronic ulcers of the duodenal bulb, 6 had chronic gastric ulcers, 15 had acute gastric ulcers, 2 had acute ulcers of the duodenal bulb, Mallory-Weiss syndrome was found in 2 patients, Dieulafoy syndrome in 10 patients and one patient had peptic ulcer of the gastro-entero-anastomosis. The endoscopic clipping was made in 11 patients, in 31 patients injections of adrenaline and coagulation were added, in 9 patients--coagulation only, in 2 patients--irrigation with caproferon, in 8--adrenaline injections. In 57 out of 61 patients reliable hemostasis was achieved.

[Mast cell reaction to total irradiation]. / Reaktsiia tuchnykh kletok na obshchee obluchenie.

A morphofunctional changes of peritoneal and mesenteric mast cell populations in rats from first minutes up to 10 day after irradiation in dose 5.5 Gr were studied. It is shown that the increased mast cell degranulation is of the first reactions of organism on irradiation. Mast cell reaction on irradiation is biphasic; the quick, short first phase is observed approximately during 0.5 h after irradiation, the gradual prolonged second phase reaches its peak about 5-12 h and continues at least during 10 days.

[Effect of short-term space flights on the activity of the renin-angiotensin-aldosterone system and on the blood concentration of cyclic nucleotides and prostaglandins]. / Vliianie kratkovremennykh kosmicheskikh poletov na aktivnost' sistemy renin-angiotenzin-al'dosteron, kontsentratsiiu tsiklicheskikh nukleotidov i prostaglandinov.

After short-term flights renal excretion of aldosterone increased, thus suggesting its enhanced production and metabolism. An adequate increase of aldosterone synthesis was accompanied by an increase of its concentration in blood. An inadequate activation of mineralocorticoids manifested as a lower concentration of blood aldosterone and a greater excretion of aldosterone in the urine. These differences in the mineralocorticoid activity were determined by the renin-angiotensin system whose activity was associated not only with fluid-electrolyte metabolism but also with changes in the concentration of cyclic nucleotides and prostaglandins that reflect the vascular tone and sympatho-adrenal activity. An increased activity of the renin-angiotensin system seen in most cosmonauts at an acute stage of readaptation was correlated with a higher concentration of cAMP and a lower concentration of depressor prostaglandins. The activity of the renin-angiotensin system declined in parallel with the decrease of the blood content of cAMP.

[Results of endocrinolgic studies of the 3rd international crew of the scientific orbital station complex; Soyuz 29 - Salyut 6 - Soyuz 31 (joint space flight enterprise of the USSR - GDR). 2. Hormones and biologically active substances in blood]. / Ergebnisse endokrinologischer Untersuchungen bei der 3. internationalen Besatzung des wissenschaftlichen Orbitalkomplexes Sojuz 29 - Saljut 6 - Sojuz 31 (gemeinsames Raumflugunternehmen UdSSR - DDR) 2. Mitteilung: Hormone und biologisch aktive Stoffe im Blut.

Cortisol, insulin, somatotropin, thyreotropin, thyroxine, triiodothyronine, testosterone, aldosterone, c-AMP, c-GMP, prostaglandins (PGF1-x, PGF2-x, PGA + E), and renin concentrations in serum or plasma of the venous blood of the third international crew of the scientific orbital complex of "Soyuz 29 - Salyut 6 - Soyuz 31" were determined following the 7-day space flight. The increased activity of the renin-angiotensin-aldosterone system before the flight as well as variations in the pressor/depressor prostaglandin ratios indicate an increased strain during the pre-flight period. During the first stage of the post-flight period some parameters were changed due to the landing process and the returning to earth gravity. The associated physical load and the onset of reactions for enhancement of the orthostatic tolerance resulted in an increase of cyclic nucleotid and thyroxine concentrations. The relatively higher levels of the pressor PGs of group F in comparison with the prostaglandins A + E could be evaluated as a compensatory reaction for enhancement of the orthostatic tolerance. The cortisol and STH concentrations increased with growing motor activity. The variations seen after the 7-day space flight were essentially within the reference areas. It may be assumed that the readaptation was not yet totally accomplished by the 8th day after landing.