[Comparative evaluation of therapeutic effects of 3 and 4 antitubercular agents at the initial stage of the treatment of renal tuberculosis]. / Sravnitel'naia otsenka terapevticheskogo vozdeistviia 3 i 4 protivotuberkuleznykh preparatov na initsial'nom étape lecheniia tuberkuleza pochek.

Three groups of the parameters of the therapeutic effects of 3 and 4 antituberculous drugs on renal tuberculous inflammation were identified. The primary effect of 4 drugs was much frequently manifested itself by the normalization of urinalysis and the transfer of cultured to uncultured Mycobacterium tuberculosis (MBT). The equivalent effect of 3 and 4 drugs was characterized by the similar rate of continuation of specific mycobacteriuria, by the detection of MBT in the cavernous contents from the removed tuberculosis-afflicted kidney and by the equivalent morphological characteristics of tuberculous inflammation involution. The negative impact of the therapeutic action of 4-component chemotherapy appeared as a much larger number of cases of intolerance of antituberculous drugs, hepatic and renal failures, and toxic-and-allergic reactions.

[Raising of the treatment efficacy of renal colic and prophylaxis of acute calculous pyelonephritis in patient with ureterolithiasis]. / Pidvyshchennia efektyvnosti likuvannia nyrkovoï kol'ky ta zapobihannia vynyknenniu hostsroho kal'kul'oznoho piielonefrytu u khvorykh na ureterolitiaz.

In 116 patients with renal colic, caused by stones of ureters, conservative treatment with application of hyperbaric oxygenation (HBO) was conducted. Under the influence of oxygenotherapy during 3 days obstruction of the urinary tracts in all patients had disappeared as well as acute urostasis, clinic symptoms of the renal colic, progress of an acute infectious-inflammatory process stopped, complications were eliminated. Echo-positive subjects had disappeared from kidneys, in one patient renal calculus had dissolved, in 5--calculi had reduced in size and fragmentated, in 9--had not changed. In 108 patients the ureters had freed from calculi, in 8--calculi had reduced in size and migrated in distal direction.

[Urogenital tuberculosis in the Ukraine population]. / Tuberkulez mochevykh i polovykh organov sredi naseleniia Ukrainy.

The prevalence and incidence rates of urogenital tuberculosis in the Ukraine in the past 10 years were studied. They tended to decrease in the first period (1988-1992) and to become stable in the second period (1993-1997), being equal to 10.71 and 1.0 per 100,000. In the past 5 years, the incidence of urogenital tuberculosis tended to increase among urban residents as compared to rural ones. These changes show a total trend in the population living in the radioactively polluted area.

[Qualitative and quantitative assessment of exposure to geomagnetic field variations on the functional status of the human brain]. / Kachestvennaia i kolichestvennaia otsenka vozdeistviia variatsii geomagnitnogo polia na funktsional'noe sostoianie mozga cheloveka.

The comparison of functional dynamics of human brain with reference to qualitative and quantitative characteristics of local geomagnetic field (GMF) variations was conducted. It was showed that just local GMF variations can be a principal reason of modulation the human brain's functional state. The steady and unsteady states of human brain can be determined: by geomagnetic disturbances before the observation period; by structure and doses of GMF variations; by different combinations of qualitative and quantitative characteristics of GMF variations. The optimal level of GMF activity, manifested in periodic oscillations in certain amplitude-frequency range is demanded for steady brain's functional state. The decrease of optimal GMF activity level and the appearance of aperiodic disturbances of GMF can be a reason of unsteady brain's state.

[An experimental study of the safety of a chemical monovalent tableted cholera vaccine in enteral administration]. / Eksperimental'noe izuchenie bezvrednosti kholernoi khimicheskoi monovalentnoi tabletirovannoi vaktsiny pri énteral'nom vvedenii.

The safety of experimental chemical cholera monovalent vaccine in tablets, produced by the institute "Microbe" (Saratov, USSR), has been studied. The study has shown that the vaccine, administered to adult rabbits and germ-free suckling rabbits by the enteral route, retains residual toxicity, mainly due to the presence of O-antigen. One or two administrations of 1-2 human doses of this preparation to adult rabbits induce minimal structural changes admissible from the viewpoint of safety. After immunization made in two administrations immunobiological transformation develops more rapidly and is more pronounced than after immunization in a single administration.

[The effect of different Yersinia pestis antigens on the cellular link in immunity]. / Izuchenie vliianiia razlichnykh antigenov Yersinia pestis na kletochnoe zveno immuniteta.

Immunization with live plague vaccine has been shown to give no protection to thymectomized mice from subcutaneous challenge with Y. pestis virulent strain. Under the action of the vaccine or individual Y. pestis antigens (fraction I) the functional and morphological activation of thymocytes and macrophages is observed, more pronounced in C57BL/6 mice and less pronounced in CBA mice. Y. pestis antigenic preparations (fractions I and II, pesticin) act as T-cell mitogens and are thus capable of inducing the in vitro proliferation of thymocytes. At the same time the in vivo action of fraction II induces a decrease in the level of lymphocytes in the peripheral blood of mice and the destruction of lymphocytes in their thymus and spleen.

[Ways to reduce disability as a consequence of urologic diseases]. / Puti snizheniia invalidnosti vsledstvie urologicheskikh zabolevanii.

Analysis of the disability pattern associated with urological diseases revealed that the patient's capacity for work depended rather on the nature of the lesion in the kidney or urinary tract (uni- or bilateral involvement or the involvement of a sole kidney) than on the nosological entity. The reasons of low rehabilitation levels could be explained by a late diagnosis, insufficient conservative or operational treatment, low qualification of labor examination committee and the defects of a dispensary follow-up. The authors defined the main criteria for the assessment of urologic patient's capacity for work and, on their basis, developed a mathematical simulation model for disability and techniques for individual approach in the prognosis for the labor capacity. The ways to raise the efficacy of rehabilitation measures were defined as well.

[Algorithm of tactics in the surgical treatment of patients with urologic diseases]. / Algoritm taktiki khirurgicheskogo lecheniia urologicheskikh bol'nykh.

On the basis of mathematical-statistical analysis of clinical data, 5 risk degrees permitting to predict the course of the disease were distinguished. An algorithm for management of the urologic patients is suggested.

[Morphological study of the damaging effect of an EB vaccine strain of the plague microbe in inbred mice]. / Morfologicheskoe izuchenie povrezhdaiushchego deistviia vaktsinnogo shtamma EB chumnogo mikroba u inbrednykh myshei.

The data obtained during the study of the morphological changes in the internal organs and blood of 6 mouse strains at the early stages of anti-plague immunity are presented. It has been established that the introduction of 5.10(3) and 1.10(5) m. b. of the EV vaccine strain resulted in the development of morphological changes typical of residual virulence. The degree of these changes depended on the haplotype of the animals and the dose used. The most resistant to injury induced by EV strain were CBA mice (haplotype H-2k) and the most sensitive were C57BL/6 mice (haplotype H-2b).

[Effect of intestinal microflora on the pathogenesis of cholera intoxication]. / Vliianie mikroflory kishechnika na patogenez kholernoi intoksikatsii.

Germ-free minipigs, previously treated with bacteroids, develop cholinergic reaction after the intragastric administration of Vibrio cholerae exotoxin. The intensity of this reaction, disturbances in homeostasis, and the character of morphological changes depend on the dose of choleragen, the bacteroid strain, and the presence of the concomitant (Escherichia coli) and residual microflora in the intestine.