FEATURES OF COAGULOPATHY AND SYSTEMIC INFLAMMATION IN PATIENTS AFTER COVID-19 INFECTION.

OBJECTIVE: The aim: To determine the peculiarities of laboratory data concerning blood coagulation and systemic inflammation in COVID-19 patients in three months after discharge and recovery. The state of coagulation, anticoagulation, and fibrinolytic systems, as well as their prognostic value having been well studied in hospitalized COVID-19 patients, their state three months after hospitalization, are not yet well understood. PATIENTS AND METHODS: Materials and methods: Methods of randomization, anthropometry, ECG, standard clinical blood testing, immunoenzymometry, immunoanalysis, and primary statistical analysis were used in the study. Anthropometric measurements of patients (n=20), blood samples, blood serum samples, urine samples, and statistical data were the materials of the study. RESULTS: Results: Indices of coagulation and systemic inflammation in studied patients after COVID-19 were obtained (PTT, s ; PATPT, s; Fibrinogen, g/L; Platelets ×109 /L; PCT, ng/mL; DD, µg/L; СRP, mg/L; IL -6, pg/mL; IL -10, pg/mL; Cortisol (nM/L); CIC (IU/mL); Ig A (g/L). CONCLUSION: Conclusions: Summing up the results obtained, it is possible to assert micro- and macro-vascular thromboses to be common in COVID-19 cases; they are associated with poor prognosis for diseased patients and are not completely investigated; the role of thromboses in COVID-19 course and complications are to be studied as well as the strategies of fibrinolytic therapies for such condition are to be justified. The presence of specific rheological and serological changes in patients even three months after surviving COVID-19 needs further study to understand the necessity of anti-thrombolytic drug uptake for a relatively long time.

Hygienic signs of diagnostics of early dysmetabolic disorders symptoms.

OBJECTIVE: The aim of the study was to identify certain health features among healthy people that can serve as a risk factor and lead to the further development of metabolic syndrome. PATIENTS AND METHODS: Materials and methods: A total of 79 men, completely health, were interviewed during 2019 at the Center for Health and Longevity Technology (Kyiv) to assess their health and further correction recommendations for identified abnormalities and available changes. The mean age of men was (37.18 ± 0.89) years. Non-invasive methods were used in the study: determination of anthropometric parameters - height, body weight, waist circumference, abdomen, index of ratio of waist-to-waist circumference, body mass index, body shape index. The constituent compositions of the body were performed with an InBody 220 apparatus with impedance analysis. The metabolic profile was evaluated using FITMATE, a portable metabological device. The cardiovascular profile was determined in the CARDIOLAB + HRV system. The obtained digital data were processed by the method of variational statistics using Microsoft Excel 7.0. RESULTS: Results: It was found that in 44 (54.4%) of the surveyed men, the waist circumference exceeded 94 cm. The largest number of such persons was found among men aged 31-40 years - (29.11% of the surveyed in this group) and persons aged 41-50 years - 21.52%. Fat distribution (waist circumference / hip circumference) averaged (0.83 ± 0.02). The difference in the body shape index between the group of young persons and groups of older men was established. The predisposition to metabolic disorders is established in 49,37% of cases. Determination of metabolic profile revealed a deviation toward an increase in actual metabolism in 15 people and 15 - in the direction of reducing it. CONCLUSION: Conclusions: Thus, the results of a thorough examination of healthy men showed that they may have health changes that characterize the early signs of disease risk, and their presence can be detected by simple non-invasive research methods. The doctor's task is to assign an in-depth study of the risk factors for the development of a particularly common in our time prevalence of a complex multicomponent metabolic syndrome, which includes the symptoms of the defeat of many body systems, in particular, the endocrine, cardiovascular, urinary and other in order to preserve human health and to recognize it as early as possible, prevent it and avoid complications.