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Molecules ; 27(23)2022 Dec 02.
Article in English | MEDLINE | ID: mdl-36500593

ABSTRACT

A series of sixteen A-ring modified (2,3-indolo-, 2-benzylidene) oleanonic acid derivatives, holding some cyclic amines, linear polyamines and benzylaminocarboxamides at C28, has been synthesized and screened for antiviral activity against influenza A/PuertoRico/8/34 (H1N1) and Dengue virus serotypes of DENV-1, -2, -3, -4. It was found that 28-homopiperazine 2 and 3-N-phthalyl 22 amides of oleanonic acid demonstrated high potency with selectivity index SI 27 (IC50 21 µM) and 42 (IC50 12 µM). Oleanonic acid aminoethylpiperazine amide 6 and C-azepano-erythrodiol 23 appeared to be the most effective compounds against DENV-1 (IC50's 67 and 107 µM) and -2 (IC50's 86 and 68 µM correspondingly) serotypes.


Subject(s)
Influenza A Virus, H1N1 Subtype , Influenza, Human , Triterpenes , Humans , Polyamines/pharmacology , Polyamines/therapeutic use , Influenza, Human/drug therapy , Triterpenes/therapeutic use , Antiviral Agents/therapeutic use , Amides/therapeutic use
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