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Shedding light by cancer redox-human NAD(P)H:quinone oxidoreductase 1 activation of a cloaked fluorescent dye.
Silvers, William C; Payne, Alex S; McCarley, Robin L.
Chem Commun (Camb) ; 47(40): 11264-6, 2011 Oct 28.
Article in English | MEDLINE | ID: mdl-21927746

ABSTRACT

A new quinone propionic acid-cloaked rhodamine fluorophore has its fluorescence revealed (de-cloaked) upon activation by human NAD(P)H:quinone oxidoreductase 1 (hNQO1), an upregulated enzyme in cancer cells and tumors.


Subject(s)
Enzyme Assays/methods , Fluorescent Dyes/metabolism , Quinone Reductases/metabolism , Cell Line, Tumor , Enzyme Activation , Fluorescent Dyes/chemistry , Humans , Morpholines/chemistry , Oxidation-Reduction , Spectrometry, Fluorescence
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