ABSTRACT
Purpose: To evaluate the association between clinical parameters and the diagnosis of progression using VFI (Visual Field Index) and AGIS (Advanced Glaucoma Intervention Study) score in primary open angle glaucoma. Methods: Retrospective study of 517 visual fields of 78 eyes with primary open angle glaucoma analyzed with VFI and AGIS score. Clinical data registered included: age, sphere, pachimetry, basal intraocular pressure (IOP), and IOP during the follow up. Results: Only the AGIS score diagnosis of progression was associated with the clinical parameters registered. Among the analyzed data, the mean IOP during follow up (p=0.0005) and IOP at the third month of follow up (p=0.004) were statistically associated with progression using the AGIS criteria. Conclusion: The diagnosis of perimetric progression using the AGIS score in the current study was closer to the real functional progression than the diagnosis using the VFI, as the former was associated with known risk factors for progression in glaucoma (AU)
Objetivo: Evaluar la asociación entre los parámetros clínicos y el diagnóstico de progresión utilizando el Índice del Campo Visual (VFI) y la Puntuación del Estudio de Intervención del Glaucoma en el glaucoma primario de ángulo abierto. Métodos: Estudio retrospectivo de 517 campos visuales de 78 ojos con glaucoma primario de ángulo abierto analizados con VFI y la puntuación AGIS. Los datos clínicos registrados incluyeron: edad, esfera, paquimetría, presión intraocular (PIO) basal y PIO durante el seguimiento. Resultados: Únicamente el diagnóstico de la progresión de la puntuación AGIS se asoció a los parámetros clínicos evaluados. Entre los datos analizados, la PIO media durante el seguimiento (p=0,0005) y la PIO al tercer mes de seguimiento (p=0,004) se asociaron estadísticamente a la progresión, utilizando los criterios AGIS. Conclusión: El diagnóstico de la progresión perimétrica utilizando la puntuación AGIS en el estudio actual se acercó más a la progresión funcional real que el diagnóstico utilizando el VFI, ya que la primera se asoció a los factores de riesgo conocidos para la progresión del glaucoma (AU)
Subject(s)
Humans , Glaucoma/physiopathology , Visual Field Tests/methods , Disease Progression , Retrospective Studies , Risk FactorsABSTRACT
PURPOSE: To evaluate the association between clinical parameters and the diagnosis of progression using VFI (Visual Field Index) and AGIS (Advanced Glaucoma Intervention Study) score in primary open angle glaucoma. METHODS: Retrospective study of 517 visual fields of 78 eyes with primary open angle glaucoma analyzed with VFI and AGIS score. Clinical data registered included: age, sphere, pachimetry, basal intraocular pressure (IOP), and IOP during the follow up. RESULTS: Only the AGIS score diagnosis of progression was associated with the clinical parameters registered. Among the analyzed data, the mean IOP during follow up (p = 0.0005) and IOP at the third month of follow up (p = 0.004) were statistically associated with progression using the AGIS criteria. CONCLUSION: The diagnosis of perimetric progression using the AGIS score in the current study was closer to the real functional progression than the diagnosis using the VFI, as the former was associated with known risk factors for progression in glaucoma.
Subject(s)
Glaucoma/physiopathology , Intraocular Pressure/physiology , Vision Disorders/diagnosis , Visual Fields/physiology , Aged , Aged, 80 and over , Disease Progression , Female , Glaucoma/diagnosis , Humans , Male , Middle Aged , Reproducibility of Results , Retrospective Studies , Vision Disorders/physiopathology , Visual Acuity/physiology , Visual Field Tests/methodsABSTRACT
PURPOSE: To determine the effect of mitomycin C (MMC) on the corneal endothelium after primary pterygium surgery. METHODS: This prospective, interventional, nonrandomized, observer-masked study included 46 consecutive patients (51 eyes) with primary pterygium. The bare sclera technique with 1-minute application of 0.02% MMC intraoperatively was used in all cases. The follow-up period was 3 months. Preoperative and postoperative central corneal specular microscopy was performed. The endothelial cell density, coefficient of variation of cell size, and percentage of hexagonal cells were analyzed, and the corneal thickness was measured. RESULTS: The mean endothelial cell densities preoperatively and 3 months postoperatively were 2382.35 +/- 342.07 cells per square millimeter (range, 1020-3129) and 2385.02 +/- 356.83 cells per square millimeter (range, 1001-3151), respectively (P = 0.96). The mean coefficients of variation of cell size preoperatively and 3 months postoperatively were 34.31 +/- 5.62 (range, 22-49) and 35.29 +/- 7.50 (range, 22-55), respectively (P = 0.17). The mean percentages of hexagonal cells values preoperatively and 3 months postoperatively were 52.98 +/- 7.32 (range, 32-71) and 51.61 +/- 8.98 (range, 32-67), respectively (P = 0.48). The mean pachymetry measurements preoperatively and 3 months postoperatively were 506.65 +/- 36.87 microm (range, 411-583) and 502.08 +/- 41.33 microm (range, 411-593), respectively (P = 0.99). CONCLUSIONS: One intraoperative application of 0.02% MMC for 1 minute after primary pterygium surgery does not seem to cause substantial changes in the corneal endothelium at 3 months.
